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Rôle physiologique joué par l'interleukine -6 au cours de l'exercice physique - Contribution à l'étude des mécanismes de production par le muscle et des réponses du tissu hépatique

Abstract : During prolonged exercise, skeletal muscles produce and release interleukin-6 (IL-6). This production correlates with both exercise intensity and decrease in muscle glycogen stores. IL-6 is thought to act, in an hormone-like manner, to increase endogenous glucose production by the liver.
Our first aim was to investigate the control of IL-6 gene expression in rat skeletal muscle at the end of exercise, focusing on the calcineurin signaling, an important contraction-responsive pathway. We first showed that IL-6 gene transcription occurred in oxidative muscle fibers (I and IIa) and was associated with a high calcineurin activity. In a second experiment we have shown that calcineurin inhibitors administration (ciclosporin A or FK506) significantly blunted IL-6 gene transcription in slow/oxidative muscles, resulting in no protein trafficking in the plasma. Thus, we demonstrated that calcineurin pathway is involved in IL-6 gene control in contracting skeletal muscle.
Our second aim was to study IL-6 action in the liver during exercise, especially IL-6 involvement in phosphoenolpyruvate carboxykinase (PEPCK) gene control, a key enzyme of hepatic gluconeogenesis. We provide new arguments to think that circulating IL-6 acts directly on hepatic tissue and possibly contributes to PEPCK gene transcription regulation during exercise. We also suggest that new protagonists, Peroxisome proliferator-activated receptor γ coactivator alpha (PGC-1α) and Farnesoid X receptor (FXR), may be involved in gluconeogenesis control during exercise.
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https://tel.archives-ouvertes.fr/tel-00250458
Contributor : Sébastien Banzet <>
Submitted on : Tuesday, February 12, 2008 - 9:46:19 AM
Last modification on : Wednesday, September 27, 2017 - 1:07:00 AM
Long-term archiving on: : Friday, September 28, 2012 - 9:31:05 AM

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  • HAL Id : tel-00250458, version 1

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Sébastien Banzet. Rôle physiologique joué par l'interleukine -6 au cours de l'exercice physique - Contribution à l'étude des mécanismes de production par le muscle et des réponses du tissu hépatique. Physiologie [q-bio.TO]. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00250458⟩

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