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Theses

ROLE DE LA PAXILLINE DANS LA DYNAMIQUE DES INVADOPODIA, LA DEGRADATION DE LA MATRICE EXTRACELLULAIRE ET LA TRANSMIGRATIOIN DES CELLULES BHK TRANSFORMEES AVEC L'ONCOGENE V-SRC

Abstract : V-src transformed BHK cells build invadopodia which self-organize into clusters, rings and belts, successively. Ring expansion is allowed by formation of new invadopodia at the ring periphery and disassembly of invadopodia at the ring center. The tyrosine phosphatase inhibitor, orthovanadate, enhances fast ring expansion indicating the invovlment of tyrosine phosphorylation processes both in invadopodia formation at the periphery and invadopodia disassembly at the center of the ring. The protein paxillin which is higly phosphorylated on tyrosine and promotes focal adhesion disassembly, is also a component of invadopodia and induces invadopodia disassembly at the ring center (main process of ring formation and expansion) via paxillin phosphorylation on tyrosine 31 and 118 driving to downstream Erk and calpain activations, which induce the clivage of invadopodia components.
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Theses
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https://tel.archives-ouvertes.fr/tel-00250240
Contributor : Cédric Badowski <>
Submitted on : Monday, February 11, 2008 - 1:35:35 PM
Last modification on : Friday, November 6, 2020 - 4:03:46 AM
Long-term archiving on: : Monday, May 17, 2010 - 4:59:49 PM

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  • HAL Id : tel-00250240, version 1

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Cédric Badowski. ROLE DE LA PAXILLINE DANS LA DYNAMIQUE DES INVADOPODIA, LA DEGRADATION DE LA MATRICE EXTRACELLULAIRE ET LA TRANSMIGRATIOIN DES CELLULES BHK TRANSFORMEES AVEC L'ONCOGENE V-SRC. Biologie cellulaire. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00250240⟩

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