The functions of cdk-cyclin kinase inhibitor p21, Pathol Biol, vol.48, pp.192-202, 2000. ,
WAF1, a potential mediator of p53 tumor suppression, Cell, vol.75, issue.4, pp.817-825, 1993. ,
DOI : 10.1016/0092-8674(93)90500-P
Radiation-induced cell cycle arrest compromised by p21 deficiency, Nature, vol.377, issue.6549, pp.552-557, 1995. ,
DOI : 10.1038/377552a0
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control, Cell, vol.82, issue.4, pp.675-684, 1995. ,
DOI : 10.1016/0092-8674(95)90039-X
p21 is necessary for the p53-mediated G1 arrest in human cancer cells, Cancer Res, vol.55, pp.5187-5190, 1995. ,
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest, Cell, vol.76, issue.6, pp.1013-1023, 1994. ,
DOI : 10.1016/0092-8674(94)90379-4
Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage", Cancer Research, vol.76, issue.13, pp.6304-6311, 1991. ,
DOI : 10.1158/0008-5472.CAN-16-1560
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts., Proceedings of the National Academy of Sciences, vol.92, issue.18, pp.8493-8497, 1995. ,
DOI : 10.1073/pnas.92.18.8493
Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression, Oncogene, vol.17, issue.13, pp.1691-1703, 1998. ,
DOI : 10.1038/sj.onc.1202104
The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint, Nature Cell Biology, vol.114, issue.9, pp.892-898, 2004. ,
DOI : 10.1016/S1097-2765(03)00480-5
Cdc2???cyclin E complexes regulate the G1/S phase transition, Nature Cell Biology, vol.14, issue.8, pp.831-836, 2005. ,
DOI : 10.1016/0022-1759(94)90396-4
Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage, The EMBO Journal, vol.18, issue.10, pp.2707-2721, 1999. ,
DOI : 10.1093/emboj/18.10.2707
APC/CCdc20 Controls the Ubiquitin-Mediated Degradation of p21 in Prometaphase, Molecular Cell, vol.27, issue.3, pp.462-473, 2007. ,
DOI : 10.1016/j.molcel.2007.06.013
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle, Cell, vol.77, issue.7, pp.1037-1050, 1994. ,
DOI : 10.1016/0092-8674(94)90443-X
Active RB Elicits Late G1/S Inhibition, Experimental Cell Research, vol.276, issue.2, pp.201-213, 2002. ,
DOI : 10.1006/excr.2002.5510
RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms, Molecular and Cellular Biology, vol.24, issue.12, pp.5404-5420, 2004. ,
DOI : 10.1128/MCB.24.12.5404-5420.2004
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419877
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts, Genes & Development, vol.19, issue.1, pp.114-126, 2005. ,
DOI : 10.1101/gad.1255805
Human Geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis, The EMBO Journal, vol.2, issue.15, pp.3122-3132, 2004. ,
DOI : 10.1126/science.280.5363.593
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage, Science, vol.281, issue.5383, pp.1674-1677, 1998. ,
DOI : 10.1126/science.281.5383.1674
Cdk1: the dominant sibling of Cdk2, Nature Cell Biology, vol.386, issue.8, pp.779-781, 2005. ,
DOI : 10.1038/sj.embor.7400284
Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts, The EMBO Journal, vol.22, issue.15, pp.3992-4002, 2003. ,
DOI : 10.1093/emboj/cdg387
Defect in Multiple Cell Cycle Checkpoints in Ataxia-Telangiectasia Postirradiation, Journal of Biological Chemistry, vol.271, issue.34, pp.20486-20493, 1996. ,
DOI : 10.1074/jbc.271.34.20486
Annual review of biochemistry 71, pp.333-374, 2002. ,
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair, Cell, vol.114, issue.5, pp.599-610, 2003. ,
DOI : 10.1016/j.cell.2003.08.001
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4, Journal of Biological Chemistry, vol.272, issue.41, pp.25863-25872, 1997. ,
DOI : 10.1074/jbc.272.41.25863
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase, Current Biology, vol.9, issue.1, pp.1-10, 1999. ,
DOI : 10.1016/S0960-9822(99)80041-4
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase, Journal of Biological Chemistry, vol.278, issue.28, pp.25752-25757, 2003. ,
DOI : 10.1074/jbc.M301774200
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27, The EMBO Journal, vol.18, issue.19, pp.5321-5333, 1999. ,
DOI : 10.1093/emboj/18.19.5321
Radiation-induced cell cycle arrest compromised by p21 deficiency, Nature, vol.377, issue.6549, pp.552-557, 1995. ,
DOI : 10.1038/377552a0
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after ??-irradiation, Proceedings of the National Academy of Sciences, vol.96, issue.3, pp.1002-1007, 1999. ,
DOI : 10.1073/pnas.96.3.1002
Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage, Science, vol.282, issue.5393, pp.1497-1501, 1998. ,
DOI : 10.1126/science.282.5393.1497
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53, Science, vol.281, issue.5383, pp.1677-1679, 1998. ,
DOI : 10.1126/science.281.5383.1677
The SCF ubiquitin ligase: insights into a molecular machine, Nature Reviews Molecular Cell Biology, vol.14, issue.9, pp.739-751, 2004. ,
DOI : 10.1016/S1367-5931(01)00262-9
Separate domains of p21 involved in the inhibition of
Cdk kinase and PCNA, Nature, vol.374, issue.6520, pp.386-388, 1995. ,
DOI : 10.1038/374386a0
p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex., Proceedings of the National Academy of Sciences, vol.93, issue.21, pp.11597-11602, 1996. ,
DOI : 10.1073/pnas.93.21.11597
N-Acetylation and Ubiquitin-Independent Proteasomal Degradation of p21Cip1, Molecular Cell, vol.16, issue.5, pp.839-847, 2004. ,
DOI : 10.1016/j.molcel.2004.11.011
Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107, Proceedings of the National Academy of Sciences, vol.101, issue.13, pp.4465-4470, 2004. ,
DOI : 10.1073/pnas.0400655101
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation., Genes & Development, vol.10, issue.16, pp.1979-1990, 1996. ,
DOI : 10.1101/gad.10.16.1979
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p., Genes & Development, vol.10, issue.24, pp.3081-3093, 1996. ,
DOI : 10.1101/gad.10.24.3081
The C-terminal Domain of p21 Inhibits Nucleotide Excision Repair In Vitro and In Vivo, Molecular Biology of the Cell, vol.10, issue.7, pp.2119-2129, 1999. ,
DOI : 10.1091/mbc.10.7.2119
ATR and ATRIP: Partners in Checkpoint Signaling, Science, vol.294, issue.5547, pp.1713-1716, 2001. ,
DOI : 10.1126/science.1065521
Distinct roles for cyclins E and A during DNA replication complex assembly and activation, Nature Cell Biology, vol.4, issue.7, pp.523-528, 1995. ,
DOI : 10.1038/ncb813
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state, Current Biology, vol.5, issue.11, pp.1257-1269, 1995. ,
DOI : 10.1016/S0960-9822(95)00252-1
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes, 49. den Elzen, N., and Pines, pp.72-74, 1994. ,
DOI : 10.1159/000133669
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control, Cell, vol.82, issue.4, pp.675-684, 1995. ,
DOI : 10.1016/0092-8674(95)90039-X
Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C, The Journal of Cell Biology, vol.2, issue.3, pp.425-437, 2007. ,
DOI : 10.1038/sj.embor.7400851
Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells., Genes & Development, vol.10, issue.22, pp.2819-2830, 1996. ,
DOI : 10.1101/gad.10.22.2819
Regulation of Early Events in Chromosome Replication, Current Biology, vol.14, issue.18, pp.778-786, 2004. ,
DOI : 10.1016/j.cub.2004.09.019
Current opinion in genetics & development, pp.62-68, 1999. ,
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest, Cell, vol.76, issue.6, pp.1013-1023, 1994. ,
DOI : 10.1016/0092-8674(94)90379-4
/M-Phase Transition, Molecular and Cellular Biology, vol.18, issue.1, pp.546-557, 1998. ,
DOI : 10.1128/MCB.18.1.546
Endoreplication Cell Cycles, Cell, vol.105, issue.3, pp.297-306, 2001. ,
DOI : 10.1016/S0092-8674(01)00334-8
URL : http://doi.org/10.1016/s0092-8674(01)00334-8
Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis., Genes & Development, vol.8, issue.4, pp.440-452, 1994. ,
DOI : 10.1101/gad.8.4.440
Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle, Current Opinion in Cell Biology, vol.12, issue.6, pp.676-684, 1993. ,
DOI : 10.1016/S0955-0674(00)00151-4
The Evi5 Oncogene Regulates Cyclin Accumulation by Stabilizing the Anaphase-Promoting Complex Inhibitor Emi1, Cell, vol.124, issue.2, pp.367-380, 2006. ,
DOI : 10.1016/j.cell.2005.10.038
Cdk inhibitors: on the threshold of checkpoints and development, Current Opinion in Cell Biology, vol.6, issue.6, pp.847-852, 1994. ,
DOI : 10.1016/0955-0674(94)90055-8
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins, Cell, vol.73, issue.3, pp.487-497, 1993. ,
DOI : 10.1016/0092-8674(93)90136-E
Activation of mammalian Chk1 during DNA replication arrest, The Journal of Cell Biology, vol.15, issue.5, pp.913-923, 2001. ,
DOI : 10.1038/sj.onc.1201319
p53 Regulation of G2 Checkpoint Is Retinoblastoma Protein Dependent, Molecular and Cellular Biology, vol.20, issue.12, pp.4210-4223, 2000. ,
DOI : 10.1128/MCB.20.12.4210-4223.2000
Human Cyclin a Is Required for Mitosis until Mid Prophase, The Journal of Cell Biology, vol.109, issue.2, pp.295-306, 1999. ,
DOI : 10.1016/0006-291X(92)91851-G
Kinase-Independent Function of Cyclin E, Molecular Cell, vol.25, issue.1, pp.127-139, 2007. ,
DOI : 10.1016/j.molcel.2006.11.029
Cyclin E Ablation in the Mouse, Cell, vol.114, issue.4, pp.431-443, 2003. ,
DOI : 10.1016/S0092-8674(03)00645-7
Chromosome segregation: Samurai separation of Siamese sisters, Current Biology, vol.9, issue.14, pp.531-534, 1999. ,
DOI : 10.1016/S0960-9822(99)80329-7
Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development, Genes & Development, vol.20, issue.14, pp.1880-1884, 2006. ,
DOI : 10.1101/gad.379706
Cdk2 Kinase Is Required for Entry into Mitosis as a Positive Regulator of Cdc2???Cyclin B Kinase Activity, Cell, vol.84, issue.1, pp.73-82, 1996. ,
DOI : 10.1016/S0092-8674(00)80994-0
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function., Genes & Development, vol.8, issue.24, pp.2939-2952, 1994. ,
DOI : 10.1101/gad.8.24.2939
Control of Meiotic and Mitotic Progression by the F Box Protein ??-Trcp1 In Vivo, Developmental Cell, vol.4, issue.6, pp.799-812, 2003. ,
DOI : 10.1016/S1534-5807(03)00154-0
pl5INK4B is a potentia| effector of TGF-??-induced cell
cycle arrest, Nature, vol.371, issue.6494, pp.257-261, 1994. ,
DOI : 10.1038/371257a0
The Rb/E2F pathway: expanding roles and emerging paradigms, Genes & Development, vol.14, issue.19, pp.2393-2409, 2000. ,
DOI : 10.1101/gad.813200
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases, Cell, vol.75, issue.4, pp.805-816, 1993. ,
DOI : 10.1016/0092-8674(93)90499-G
The anaphase-promoting complex: it's not just for mitosis any more, Genes & Development, vol.16, issue.17, pp.2179-2206, 2002. ,
DOI : 10.1101/gad.1013102
Inhibition of cyclin-dependent kinases by p21., Molecular Biology of the Cell, vol.6, issue.4, pp.387-400, 1995. ,
DOI : 10.1091/mbc.6.4.387
pRB plays an essential role in cell cycle arrest induced by DNA damage, Proceedings of the National Academy of Sciences, vol.95, issue.20, pp.11945-11950, 1998. ,
DOI : 10.1073/pnas.95.20.11945
Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1, Cell, vol.122, issue.3, pp.407-420, 2005. ,
DOI : 10.1016/j.cell.2005.05.029
14-3-3?? Is a p53-Regulated Inhibitor of G2/M Progression, Molecular Cell, vol.1, issue.1, pp.3-11, 1997. ,
DOI : 10.1016/S1097-2765(00)80002-7
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts., Molecular and Cellular Biology, vol.16, issue.5, pp.2402-2407, 1996. ,
DOI : 10.1128/MCB.16.5.2402
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC231229
Annual review of biochemistry 67, 425- 479 90, Cell, vol.70, issue.6, pp.993-1006, 1992. ,
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6., Molecular and Cellular Biology, vol.15, issue.5, pp.2672-2681, 1995. ,
DOI : 10.1128/MCB.15.5.2672
Roles of the CDK Phosphorylation Sites of Yeast Cdc6 in Chromatin Binding and Rereplication, Molecular Biology of the Cell, vol.18, issue.4, pp.1324-1336, 2007. ,
DOI : 10.1091/mbc.E06-06-0544
A new view of the spindle checkpoint, The Journal of Cell Biology, vol.154, issue.5, pp.909-911, 2001. ,
DOI : 10.1101/gad.13.16.2039
S and G2 Phase Roles for Cdk2 Revealed by Inducible Expression of a Dominant-Negative Mutant in Human Cells, Molecular and Cellular Biology, vol.21, issue.8, pp.2755-2766, 2001. ,
DOI : 10.1128/MCB.21.8.2755-2766.2001
DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint, Proceedings of the National Academy of Sciences, vol.102, issue.4, pp.1065-1070, 2005. ,
DOI : 10.1073/pnas.0409130102
p53 regulates a G2 checkpoint through cyclin B1, Proceedings of the National Academy of Sciences, vol.96, issue.5, pp.2147-2152, 1999. ,
DOI : 10.1073/pnas.96.5.2147
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases, Trends in Cell Biology, vol.10, issue.10, pp.429-439, 2000. ,
DOI : 10.1016/S0962-8924(00)01834-1
Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14, Current Biology, vol.9, issue.5, pp.227-236, 1999. ,
DOI : 10.1016/S0960-9822(99)80111-0
Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis, Current Biology, vol.12, issue.11, pp.900-905, 2002. ,
DOI : 10.1016/S0960-9822(02)00887-4
Phosphorylation and Activation of 13S Condensin by Cdc2 in Vitro, Science, vol.282, issue.5388, pp.487-490, 1998. ,
DOI : 10.1126/science.282.5388.487
How Proteolysis Drives the Cell Cycle, Science, vol.274, issue.5293, pp.1652-1659, 1996. ,
DOI : 10.1126/science.274.5293.1652
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase??progression, Genes & Development, vol.12, issue.15, pp.2278-2292, 1998. ,
DOI : 10.1101/gad.12.15.2278
p53: puzzle and paradigm., Genes & Development, vol.10, issue.9, pp.1054-1072, 1996. ,
DOI : 10.1101/gad.10.9.1054
URL : http://www.genesdev.org/cgi/content/short/10/9/1054
How the Cyclin Became a Cyclin, Cell, vol.97, issue.4, pp.431-434, 1999. ,
DOI : 10.1016/S0092-8674(00)80753-9
Sister chromatid cohesion: the beginning of a long and beautiful relationship, Current Opinion in Cell Biology, vol.12, issue.3, pp.297-301, 2000. ,
DOI : 10.1016/S0955-0674(00)00092-2
Regulation of APC Activity by Phosphorylation and Regulatory Factors, The Journal of Cell Biology, vol.110, issue.4, pp.791-800, 1999. ,
DOI : 10.1126/science.282.5394.1721
Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1, Molecular Biology of the Cell, vol.11, issue.5, pp.1555-1569, 2000. ,
DOI : 10.1091/mbc.11.5.1555
Wild-type p53 is a cell cycle checkpoint determinant following irradiation., Proceedings of the National Academy of Sciences, vol.89, issue.16, pp.7491-7495, 1992. ,
DOI : 10.1073/pnas.89.16.7491
Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts, Molecular Cell, vol.6, issue.4, pp.839-849, 2000. ,
DOI : 10.1016/S1097-2765(05)00092-4
Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex, Science, vol.304, issue.5667, pp.93-96, 2004. ,
DOI : 10.1126/science.1091496
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex, Science, vol.308, issue.5721, pp.551-554, 2005. ,
DOI : 10.1126/science.1108297
p53, the Cellular Gatekeeper for Growth and Division, Cell, vol.88, issue.3, pp.323-331, 1997. ,
DOI : 10.1016/S0092-8674(00)81871-1
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus, The EMBO Journal, vol.24, issue.2, pp.395-404, 2005. ,
DOI : 10.1038/sj.emboj.7600520
Feedback control of mitosis in budding yeast, Cell, vol.66, issue.3, pp.519-531, 1991. ,
DOI : 10.1016/0092-8674(81)90015-5
Identification of a Human Mitotic Checkpoint Gene: hsMAD2, Science, vol.274, issue.5285, pp.246-248, 1996. ,
DOI : 10.1126/science.274.5285.246
MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity, Proceedings of the National Academy of Sciences, vol.94, issue.23, pp.12431-12436, 1997. ,
DOI : 10.1073/pnas.94.23.12431
Cyclin-dependent Kinases Phosphorylate Human Cdt1 and Induce Its Degradation, Journal of Biological Chemistry, vol.279, issue.17, pp.17283-17288, 2004. ,
DOI : 10.1074/jbc.C300549200
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA, Proceedings of the National Academy of Sciences, vol.99, issue.13, pp.8672-8676, 2002. ,
DOI : 10.1073/pnas.132269599
Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?, Cell, vol.75, issue.4, pp.765-778, 1993. ,
DOI : 10.1016/0092-8674(93)90496-D
Cell-cycle inhibition by independent CDK and PCNA binding domains in
p21Cip1, Nature, vol.375, issue.6527, pp.159-161, 1995. ,
DOI : 10.1038/375159a0
A Cdt1???geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus, The EMBO Journal, vol.24, issue.24, pp.5764-5774, 2006. ,
DOI : 10.1038/sj.emboj.7601436
URL : https://hal.archives-ouvertes.fr/hal-00121695
The APC/C inhibitor, Emi1, is essential for prevention of rereplication, Genes & Development, vol.21, issue.2, pp.184-194, 2007. ,
DOI : 10.1101/gad.1495007
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage., Genes & Development, vol.9, issue.8, pp.935-944, 1995. ,
DOI : 10.1101/gad.9.8.935
Loss of centrioles and polyploidization in follicle cells of Drosophila melanogaster, Experimental Cell Research, vol.118, issue.2, pp.404-410, 1979. ,
DOI : 10.1016/0014-4827(79)90167-8
Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability, The EMBO Journal, vol.21, issue.21, pp.5911-5920, 2002. ,
DOI : 10.1093/emboj/cdf567
Recombinant Cdt1 Induces Rereplication of G2 Nuclei in Xenopus Egg Extracts, Current Biology, vol.15, issue.2, pp.146-153, 2005. ,
DOI : 10.1016/j.cub.2004.12.002
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation., Molecular and Cellular Biology, vol.17, issue.1, pp.355-363, 1997. ,
DOI : 10.1128/MCB.17.1.355
MILESTONES IN CELL DIVISION TO CYCLE OR NOT TO CYCLE: A CRITICAL DECISION IN CANCER, Nature Reviews Cancer, vol.1, issue.3, pp.222-231, 2001. ,
DOI : 10.1038/35106065
Prophase Destruction of Emi1 by the SCF??TrCP/Slimb Ubiquitin Ligase Activates the Anaphase Promoting Complex to Allow Progression beyond Prometaphase, Developmental Cell, vol.4, issue.6, pp.813-826, 2003. ,
DOI : 10.1016/S1534-5807(03)00153-9
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene., Genes & Development, vol.9, issue.6, pp.650-662, 1995. ,
DOI : 10.1101/gad.9.6.650
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase, Science, vol.282, issue.5395, pp.1893-1897, 1998. ,
DOI : 10.1126/science.282.5395.1893
Modulation of microtubule dynamics during the cell cycle, Current Opinion in Cell Biology, vol.8, issue.1, pp.23-29, 1996. ,
DOI : 10.1016/S0955-0674(96)80044-5
Loss of Geminin induces rereplication in the presence of functional p53, The Journal of Cell Biology, vol.14, issue.4, pp.473-482, 2004. ,
DOI : 10.1126/science.1083430
Cell Proliferation without Cyclin E-CDK2, Cell, vol.114, issue.4, pp.398-399, 2003. ,
DOI : 10.1016/S0092-8674(03)00649-4
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor, Genes & Development, vol.20, issue.17, pp.2410-2420, 2006. ,
DOI : 10.1101/gad.1454006
Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells, Oncogene, vol.23, issue.19, pp.3361-3367, 2004. ,
DOI : 10.1038/sj.onc.1207446
Current opinion in genetics, & development, vol.8, issue.1, pp.21-27, 1998. ,
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis, EMBO reports, vol.19, issue.1, pp.71-79, 2000. ,
DOI : 10.1093/embo-reports/kvd018
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors, Annual Review of Cell and Developmental Biology, vol.13, issue.1, pp.261-291, 1997. ,
DOI : 10.1146/annurev.cellbio.13.1.261
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome, Proceedings of the National Academy of Sciences, vol.101, issue.21, pp.7937-7942, 2004. ,
DOI : 10.1073/pnas.0402442101
The retinoblastoma gene family: cousins with overlapping interests, Trends in Genetics, vol.14, issue.6, pp.223-229, 1998. ,
DOI : 10.1016/S0168-9525(98)01470-X
Cyclin Ubiquitination: The destructive end of mitosis, Cell, vol.81, issue.2, pp.149-152, 1995. ,
DOI : 10.1016/0092-8674(95)90322-4
Recycling the Cell Cycle, Cell, vol.116, issue.2, pp.221-234, 2004. ,
DOI : 10.1016/S0092-8674(03)01080-8
The C-terminal Region of p21 Is Involved in Proliferating Cell Nuclear Antigen Binding but Does Not Appear to Be Required for Growth Inhibition, Journal of Biological Chemistry, vol.270, issue.29, pp.17060-17063, 1995. ,
DOI : 10.1074/jbc.270.29.17060
Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids, Science, vol.288, issue.5470, pp.1379-1385, 2000. ,
DOI : 10.1126/science.288.5470.1379
Regulation of the cell cycle during early Xenopus development, Cell, vol.37, issue.3, pp.731-742, 1984. ,
DOI : 10.1016/0092-8674(84)90409-4
Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint, The Journal of Cell Biology, vol.130, issue.4, pp.929-939, 1995. ,
DOI : 10.1083/jcb.130.4.929
/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication, Molecular and Cellular Biology, vol.18, issue.1, pp.629-643, 1998. ,
DOI : 10.1128/MCB.18.1.629
Assembly-disassembly of the nuclear lamina, Current Opinion in Cell Biology, vol.4, issue.1, pp.105-109, 1992. ,
DOI : 10.1016/0955-0674(92)90066-L
Targets of cyclin-dependent protein kinases, Current Opinion in Cell Biology, vol.5, issue.2, pp.187-193, 1993. ,
DOI : 10.1016/0955-0674(93)90101-U
Polo-like kinases: positive regulators of cell division from start to finish, Current Opinion in Cell Biology, vol.10, issue.6, pp.776-783, 1998. ,
DOI : 10.1016/S0955-0674(98)80121-X
Control of DNA replication licensing in a cell cycle, Genes to Cells, vol.85, issue.6, pp.523-534, 2002. ,
DOI : 10.1128/MCB.20.9.3086-3096.2000
Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region, Journal of Biological Chemistry, vol.279, issue.29, pp.30807-30816, 2004. ,
DOI : 10.1074/jbc.M312644200
CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis, Molecular Cell, vol.5, issue.1, pp.85-95, 2000. ,
DOI : 10.1016/S1097-2765(00)80405-0
Universal control mechanism regulating onset of M-phase, Nature, vol.344, issue.6266, pp.503-508, 1990. ,
DOI : 10.1038/344503a0
The G2-phase DNA-damage checkpoint, Trends in Cell Biology, vol.10, issue.7, pp.296-303, 2000. ,
DOI : 10.1016/S0962-8924(00)01773-6
Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase delta and replication factor C, Genes to Cells, vol.4, issue.6, pp.357-369, 1998. ,
DOI : 10.1074/jbc.273.2.713
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice, Nature Genetics, vol.35, issue.1, pp.25-31, 2003. ,
DOI : 10.1038/ng1232
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27, Science, vol.269, issue.5224, pp.682-685, 1995. ,
DOI : 10.1126/science.7624798
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21, Journal of Biological Chemistry, vol.270, issue.37, pp.22008-22016, 1995. ,
DOI : 10.1074/jbc.270.37.22008
G1 events and regulation of cell proliferation, Science, vol.246, issue.4930, pp.603-608, 1989. ,
DOI : 10.1126/science.2683075
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells, Science, vol.267, issue.5200, pp.1024-1027, 1995. ,
DOI : 10.1126/science.7863329
Mitotic and G2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216, Science, vol.277, issue.5331, pp.1501-1505, 1997. ,
DOI : 10.1126/science.277.5331.1501
Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21Cip1, The EMBO Journal, vol.18, issue.19, pp.5310-5320, 1999. ,
DOI : 10.1093/emboj/18.19.5310
The Anaphase-Promoting Complex, Molecular Cell, vol.9, issue.5, pp.931-943, 2002. ,
DOI : 10.1016/S1097-2765(02)00540-3
URL : http://doi.org/10.1016/s1097-2765(02)00540-3
The anaphase promoting complex/cyclosome: a machine designed to destroy, Nature Reviews Molecular Cell Biology, vol.4, issue.9, pp.644-656, 2006. ,
DOI : 10.1126/science.274.5290.1201
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast., Genes & Development, vol.10, issue.12, pp.1516-1531, 1996. ,
DOI : 10.1101/gad.10.12.1516
The Centromere: Hub of Chromosomal Activities, Science, vol.270, issue.5242, pp.1591-1594, 1995. ,
DOI : 10.1126/science.270.5242.1591
Mechanism of Inhibition of Proliferating Cell Nuclear Antigen-Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21, Biochemistry, vol.34, issue.27, pp.8869-8875, 1995. ,
DOI : 10.1021/bi00027a039
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals, Cell, vol.78, issue.1, pp.59-66, 1994. ,
DOI : 10.1016/0092-8674(94)90572-X
The p53 pathway, The Journal of Pathology, vol.2, issue.1, pp.112-126, 1999. ,
DOI : 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry, Nature, vol.11, issue.7017, pp.588-595, 2004. ,
DOI : 10.1093/emboj/cdg627
Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex, Cell, vol.105, issue.5, pp.645-655, 2001. ,
DOI : 10.1016/S0092-8674(01)00361-0
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins, Genes & Development, vol.15, issue.24, pp.3278-3285, 2001. ,
DOI : 10.1101/gad.945701
E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints, Genes & Development, vol.16, issue.2, pp.245-256, 2002. ,
DOI : 10.1101/gad.949802
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155321
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle, The Journal of Cell Biology, vol.127, issue.5, pp.1301-1310, 1994. ,
DOI : 10.1083/jcb.127.5.1301
Site-specific and temporally-regulated retinoblastoma protein dephosphorylation by protein phosphatase type 1, Oncogene, vol.20, issue.29, pp.3776-3785, 2001. ,
DOI : 10.1038/sj.onc.1204518
Cdk1 is sufficient to drive the mammalian cell cycle, Nature, vol.14, issue.7155, pp.811-815, 2007. ,
DOI : 10.1006/meth.2001.1262
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, Nature, vol.366, issue.6456, pp.704-707, 1993. ,
DOI : 10.1038/366704a0
Waiting for Anaphase, Cell, vol.103, issue.7, pp.997-1000, 2000. ,
DOI : 10.1016/S0092-8674(00)00202-6
URL : http://doi.org/10.1016/s0092-8674(00)00202-6
Chromosome Dynamics: New Light on Aurora B Kinase Function, Current Biology, vol.12, issue.13, pp.458-460, 2002. ,
DOI : 10.1016/S0960-9822(02)00945-4
Cyclin E-CDK2 is a regulator of p27Kip1., Genes & Development, vol.11, issue.11, pp.1464-1478, 1997. ,
DOI : 10.1101/gad.11.11.1464
Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination, Molecular Cell, vol.5, issue.2, pp.403-410, 2000. ,
DOI : 10.1016/S1097-2765(00)80435-9
Cancer Cell Cycles, Science, vol.274, issue.5293, pp.1672-1677, 1996. ,
DOI : 10.1126/science.274.5293.1672
Inhibitors of mammalian G1 cyclin-dependent kinases., Genes & Development, vol.9, issue.10, pp.1149-1163, 1995. ,
DOI : 10.1101/gad.9.10.1149
CDK inhibitors: positive and negative regulators of G1-phase progression, Genes & Development, vol.13, issue.12, pp.1501-1512, 1999. ,
DOI : 10.1101/gad.13.12.1501
Living with or without cyclins and cyclin-dependent kinases, Genes & Development, vol.18, issue.22, pp.2699-2711, 2004. ,
DOI : 10.1101/gad.1256504
URL : http://www.genesdev.org/cgi/content/short/18/22/2699
A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex-Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression, Molecular and Cellular Biology, vol.21, issue.11, pp.3692-3703, 2001. ,
DOI : 10.1128/MCB.21.11.3692-3703.2001
A revised picture of the E2F transcriptional network and RB function, Current Opinion in Cell Biology, vol.14, issue.6, pp.684-691, 2002. ,
DOI : 10.1016/S0955-0674(02)00388-5
Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption, Molecular and Cellular Biology, vol.19, issue.1, pp.205-215, 1999. ,
DOI : 10.1128/MCB.19.1.205
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1, Oncogene, vol.21, issue.53, pp.8067-8074, 2002. ,
DOI : 10.1038/sj.onc.1206019
Cdt1 Phosphorylation by Cyclin A-dependent Kinases Negatively Regulates Its Function without Affecting Geminin Binding, Journal of Biological Chemistry, vol.279, issue.19, pp.19691-19697, 2004. ,
DOI : 10.1074/jbc.M313175200
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1), Proceedings of the National Academy of Sciences, vol.103, issue.32, pp.11964-11969, 2006. ,
DOI : 10.1073/pnas.0604987103
Phosphorylation of Cdc20 by Bub1 Provides a Catalytic Mechanism for APC/C Inhibition by the Spindle Checkpoint, Molecular Cell, vol.16, issue.3, pp.387-397, 2004. ,
DOI : 10.1016/j.molcel.2004.09.031
Mechanisms of G2 Arrest in Response to Overexpression of p53, Molecular Biology of the Cell, vol.10, issue.11, pp.3607-3622, 1999. ,
DOI : 10.1091/mbc.10.11.3607
A role for ATR in the DNA damage-induced phosphorylation of p53, Genes & Development, vol.13, issue.2, pp.152-157, 1999. ,
DOI : 10.1101/gad.13.2.152
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome, The EMBO Journal, vol.20, issue.10, pp.2367-2375, 2001. ,
DOI : 10.1093/emboj/20.10.2367
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21, Cell, vol.78, issue.1, pp.67-74, 1994. ,
DOI : 10.1016/0092-8674(94)90573-8
Activity, Molecular and Cellular Biology, vol.19, issue.10, pp.7011-7019, 1999. ,
DOI : 10.1128/MCB.19.10.7011
Chromosome cohesion: A polymerase for chromosome bridges, Current Biology, vol.10, issue.19, pp.698-700, 2000. ,
DOI : 10.1016/S0960-9822(00)00709-0
A p53-Dependent Checkpoint Pathway Prevents Rereplication, Molecular Cell, vol.11, issue.4, pp.997-1008, 2003. ,
DOI : 10.1016/S1097-2765(03)00099-6
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1, The EMBO Journal, vol.16, issue.17, pp.5334-5344, 1997. ,
DOI : 10.1093/emboj/16.17.5334
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA, Nature, vol.369, issue.6481, pp.574-578, 1994. ,
DOI : 10.1038/369574a0
Cyclin-Dependent Kinase Inhibitor p21 Modulates the DNA Primer-Template Recognition Complex, Molecular and Cellular Biology, vol.18, issue.7, pp.4177-4187, 1998. ,
DOI : 10.1128/MCB.18.7.4177
Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase, Cell, vol.103, issue.3, pp.399-410, 2000. ,
DOI : 10.1016/S0092-8674(00)00132-X
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21, Nature, vol.381, issue.6584, pp.713-716, 1996. ,
DOI : 10.1038/381713a0
Initiation of Eukaryotic DNA Replication, Molecular Cell, vol.5, issue.4, pp.617-627, 2000. ,
DOI : 10.1016/S1097-2765(00)80241-5
Cellular responses to DNA damage, Current Opinion in Cell Biology, vol.10, issue.2, pp.240-247, 1998. ,
DOI : 10.1016/S0955-0674(98)80146-4
Mad2 transiently associates with an APC/p55Cdc complex during mitosis, Proceedings of the National Academy of Sciences, vol.95, issue.19, pp.11193-11198, 1998. ,
DOI : 10.1073/pnas.95.19.11193
Current opinion in genetics & development, pp.83-90, 2001. ,
The retinoblastoma protein and cell cycle control, Cell, vol.81, issue.3, pp.323-330, 1995. ,
DOI : 10.1016/0092-8674(95)90385-2
The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint, The Journal of Cell Biology, vol.132, issue.1, pp.111-123, 1996. ,
DOI : 10.1083/jcb.132.1.111
A family of mammalian F-box proteins, Current Biology, vol.9, issue.20, pp.1180-1182, 1999. ,
DOI : 10.1016/S0960-9822(00)80021-4
Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1, Science, vol.290, issue.5500, pp.2309-2312, 2000. ,
DOI : 10.1126/science.290.5500.2309
Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism, Science, vol.278, issue.5345, pp.1957-1960, 1997. ,
DOI : 10.1126/science.278.5345.1957
Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs, Genes to Cells, vol.24, issue.1, pp.63-73, 2005. ,
DOI : 10.1111/j.1365-2443.2005.00815.x
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21CIP1/WAF1 and cyclin D proteins, Proceedings of the National Academy of Sciences, vol.95, issue.19, pp.11324-11329, 1998. ,
DOI : 10.1073/pnas.95.19.11324
Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex, Science, vol.282, issue.5394, pp.1721-1724, 1998. ,
DOI : 10.1126/science.282.5394.1721
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects, The EMBO Journal, vol.22, issue.3, pp.713-723, 2003. ,
DOI : 10.1093/emboj/cdg060
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140744
What is the restriction point?, Current Opinion in Cell Biology, vol.7, issue.6, pp.835-842, 1995. ,
DOI : 10.1016/0955-0674(95)80067-0
Life without Kinase: Cyclin E Promotes DNA Replication Licensing and Beyond, Molecular Cell, vol.25, issue.2, pp.175-176, 2007. ,
DOI : 10.1016/j.molcel.2007.01.008
URL : http://doi.org/10.1016/j.molcel.2007.01.008
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints, Proceedings of the National Academy of Sciences, vol.99, issue.23, pp.14795-14800, 2002. ,
DOI : 10.1073/pnas.182557299
Structure of the Cul1???Rbx1???Skp1???F boxSkp2 SCF ubiquitin ligase complex, Nature, vol.416, issue.6882, pp.703-709, 2002. ,
DOI : 10.1038/416703a
Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G2/M Checkpoint, Molecular and Cellular Biology, vol.24, issue.16, pp.7140-7150, 2004. ,
DOI : 10.1128/MCB.24.16.7140-7150.2004
Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition, Molecular and Cellular Biology, vol.24, issue.14, pp.6268-6277, 2004. ,
DOI : 10.1128/MCB.24.14.6268-6277.2004
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes, Science, vol.300, issue.5625, pp.1542-1548, 2003. ,
DOI : 10.1126/science.1083430