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Du monomère à la cellule: Modèles de la dynamique de l'actine

Julien Berro 1
TIMC - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : Actin filaments are biological polymers that are very abundant in eucaryot cytoskeleton. Their auto-assembly and auto-organization are highly dynamic and are essential in cell motility and membrane deformations. In this thesis we propose three approaches, on different scales, in order to enlighten mechanisms for the regulation of assembly of, organization of and production of force by biological filaments such as actin filaments. First, we have developed a stochastic multi-agent simulation tool for studying biological filaments taking into consideration interactions on the nanometer scale. This new tool allowed us to bring out the acceleration of actin monomer turnover due to fragmentation of filaments by ADF/Cofilin and the symmetry breaking induced by this protein, which agree well with experimental data from L. Blanchoin team (CEA Grenoble). Secondly, we studied a continuous model for filament buckling, providing, on the one hand, an estimation of forces exerted in vitro or in vivo with respect to extremity attachment conditions and, on the other hand, limit conditions for buckling. Thirdly, we developed a framework for organizing kinetic biochemical data from reaction networks, which was used for the regulation of actin polymerization. These three modeling approaches improved the knowledge on actin dynamics and are useful complements for experimental approaches in biology.
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Submitted on : Monday, January 28, 2008 - 3:08:54 PM
Last modification on : Thursday, November 19, 2020 - 3:56:08 PM
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  • HAL Id : tel-00221384, version 1



Julien Berro. Du monomère à la cellule: Modèles de la dynamique de l'actine. Mathématiques [math]. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00221384⟩



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