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Développement de méthodes combinatoires pour la découverte de ligands à base de cyclopeptides.

Abstract : Combinatorial chemistry represents an efficient strategy to discover new bioactives molecules. In this context, we investigated two combinatorial approaches to prepare libraries of cyclopeptide-based ligands. First, we developed a randomized chemoselective assembly of biomolecules onto peptidic template. We thus obtained in solution libraries of heteroglycoclusters that were screened by affinity chromatography with immobilized Concanavalin A as model lectin. In a second approach, libraries of cyclic peptides have been prepared on solid support by split and mix method. These libraries have been designed following the decoding algorithm developed by Reymond's group (Bern, Switzerland) which allows the sequence determination of each peptide. The screening with vitamin B12 and Casein Kinase 2 have been realized
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https://tel.archives-ouvertes.fr/tel-00212692
Contributor : Vincent Duléry <>
Submitted on : Wednesday, January 23, 2008 - 8:39:58 AM
Last modification on : Friday, November 6, 2020 - 4:15:02 AM
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  • HAL Id : tel-00212692, version 1

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Vincent Duléry. Développement de méthodes combinatoires pour la découverte de ligands à base de cyclopeptides.. Autre. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00212692⟩

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