Skip to Main content Skip to Navigation
Theses

Les mécanismes de la vulnérabilité à la chaleur : implication des stress systémique et cellulaire.

Abstract : Heat stroke is a serious illness without specific treatment. Heat stroked animals exhibit inflammatory processes accompanied by metabolic imbalance. These impairments take place despite of heat shock proteins (Hsp70) induction and glucocorticoid secretion. The role of Hsp70 mRNA and glucocorticoids in heat tolerance has been analyzed. Vigil animals intolerant to heat present: severe hyperthermia and dehydration, metabolic imbalance, lesser glucocorticoid production, signs of cellular hyperactivation and aggression, activation of inflammatory processes. The Hsp70 mRNA expression depends on the intensity of the stressor and appears, in the chain of causality, as a consequence of the heat aggression. Glucocorticoids are involved in tolerance by reducing local inflammatory processes and favouring the expression of the inhibitory factor κBα (IκBα) mRNA.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00203725
Contributor : Virginie Michel (épouse Debard) <>
Submitted on : Friday, January 11, 2008 - 10:04:14 AM
Last modification on : Monday, October 19, 2020 - 11:11:37 AM
Long-term archiving on: : Friday, November 25, 2016 - 8:54:04 PM

Identifiers

  • HAL Id : tel-00203725, version 1

Collections

SSA

Citation

Virginie Michel. Les mécanismes de la vulnérabilité à la chaleur : implication des stress systémique et cellulaire.. Neurosciences [q-bio.NC]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00203725⟩

Share

Metrics

Record views

432

Files downloads

4833