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Etude du rôle du récepteur aux hormones thyroïdiennes TRalpha 1 dans la prolifération normale et pathologique de l'épithélium intestinal

Abstract : The intestinal epithelium is a perpetually renewing tissue. This renewal implies adult stem cells, localized at the basis of the villi in the intestinal crypts, that give birth to proliferative progenitors. The control of the proliferation of stem cells and progenitors is a key factor for maintaining the homeostasis of the tissue. The main signalling pathway implied in the control of the epithelial cell proliferation is the Wnt pathway.
The thyroid hormones (TH) act through nuclear receptors. Previous work led in the lab has showed that TRα1 is the TH receptor that controls the proliferation of the intestinal crypt cells.
During my PhD, I have showed that TRα1 and TH are important for the expression and the activation of several partners of the Wnt pathway, as in the initiation of hyperproliferative pathologies in mouse intestine.
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https://tel.archives-ouvertes.fr/tel-00203528
Contributor : Elsa Kress <>
Submitted on : Thursday, January 10, 2008 - 1:49:39 PM
Last modification on : Saturday, June 6, 2020 - 12:40:01 PM
Long-term archiving on: : Tuesday, April 13, 2010 - 3:41:46 PM

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  • HAL Id : tel-00203528, version 1
  • PRODINRA : 250980

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Elsa Kress. Etude du rôle du récepteur aux hormones thyroïdiennes TRalpha 1 dans la prolifération normale et pathologique de l'épithélium intestinal. Biochimie [q-bio.BM]. Ecole normale supérieure de lyon - ENS LYON, 2007. Français. ⟨tel-00203528⟩

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