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Ondes capillaires à une interface fluide fonctionnalisée : détection micromécanique de brins d'ADN

Abstract : Whatever the context is (biotechnology, molecular biology) biochips are now considered as a relevant system to detect biological molecules. The recent idea of a fluid biochip, which relies on the capture of target molecules at a functionalized liquid interface, allows in particular the use of the rheological interfacial properties as a micromechanical diagnostic : a change in the surface rheology can be induced by the hybridization between probe and target molecules. The relevance of such a device in the field of DNA detection is studied experimentally. A meniscus capillary wave net is promoted at the surface of a water sub-phase contained in cylindrical cell submitted to vertical vibration. The geometry of the wave net, which is characterized by two optical techniques, demonstrates a sensitivity to the surface tension and to the rheological interfacial properties. The value of these micromechanical parameters depends on the fact the DNA is single-stranded or double-stranded.
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https://tel.archives-ouvertes.fr/tel-00203106
Contributor : Cyril Picard <>
Submitted on : Wednesday, January 9, 2008 - 1:49:18 AM
Last modification on : Tuesday, February 2, 2021 - 9:06:03 AM
Long-term archiving on: : Thursday, September 27, 2012 - 1:55:10 PM

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  • HAL Id : tel-00203106, version 1

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Cyril Picard. Ondes capillaires à une interface fluide fonctionnalisée : détection micromécanique de brins d'ADN. Dynamique des Fluides [physics.flu-dyn]. Institut National Polytechnique de Grenoble - INPG, 2007. Français. ⟨tel-00203106⟩

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