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Identification et caractérisation d'un récepteur d'enveloppe au virus de leucémie T humaine (HTLV), le transporteur de glucose GLUT1

Abstract : The HTLV-1 (Human T-cell Leukaemia Virus type 1) is responsible for the adult T-cell leukaemia (ATL) and the tropical spastic paraparesis (TSP/HAM). The HTLV receptor is ubiquitous. We have shown that the HTLV receptor is expressed upon T lymphocytes activation, but not on resting T lymphocytes. We have found that the HTLV Env blocks lactate production. We demonstrated that this is due to the inhibition of the glucose uptake. Accordingly, we have shown that the glucose transporter GLUT1 is the HTLV receptor. These observations allowed us to propose new models of pathogenesis.
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https://tel.archives-ouvertes.fr/tel-00202039
Contributor : Nicolas Manel <>
Submitted on : Friday, January 4, 2008 - 6:16:05 AM
Last modification on : Monday, June 11, 2018 - 4:46:01 PM
Long-term archiving on: : Tuesday, April 13, 2010 - 4:11:37 PM

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  • HAL Id : tel-00202039, version 1

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Nicolas Manel. Identification et caractérisation d'un récepteur d'enveloppe au virus de leucémie T humaine (HTLV), le transporteur de glucose GLUT1. Autre [q-bio.OT]. Université Montpellier II - Sciences et Techniques du Languedoc, 2005. Français. ⟨tel-00202039⟩

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