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Développements en imagerie RMN spirale et application à la caractérisation de la perméabilité de la barrière hémato-encéphalique sur deux modèles de tumeurs intracérébrales

Abstract : The results presented in this work were obtained as part of methodological developments in magnetic resonance imaging. First of all, the setting of the rapid imaging technique using a k-space sampling scheme along a variable density spiral is described. Numerical simulations were used to optimize the acquisitions parameters and to compare different reconstruction techniques. An original approach to calibrate the k-space trajectory was proposed. Then, spiral imaging was used to implement a method to measure the blood brain barrier permeability to Gd-DOTA. This protocol was combined to blood volume and vessel size index measurements using Sinerem®. The results obtained highlighted differences between the microvascular parameters measured on C6 and RG2 tumor models. The presence of Sinerem® induces a mean decrease of the transfer constant across the vascular wall (Ktrans), in the tumor, of 24%. This study also showed extravasation of the Sinerem®, during the first two hours after the product injection, only in the RG2 tumors.
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https://tel.archives-ouvertes.fr/tel-00201228
Contributor : Marine Beaumont <>
Submitted on : Thursday, December 27, 2007 - 11:40:39 AM
Last modification on : Friday, November 6, 2020 - 4:01:28 AM
Long-term archiving on: : Tuesday, April 13, 2010 - 3:44:49 PM

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  • HAL Id : tel-00201228, version 1

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INSERM | UJF | U836 | UGA

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Marine Beaumont. Développements en imagerie RMN spirale et application à la caractérisation de la perméabilité de la barrière hémato-encéphalique sur deux modèles de tumeurs intracérébrales. Biophysique [physics.bio-ph]. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00201228⟩

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