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Conformation et dynamique de biomolècules en phase gazeuse

Abstract : We have developed a new experimental set-up which couple a quadrupole ion trap mass spectrometer with a tuneable UV-Visible laser OPO. This thesis's work deals with the optical properties and the photofragmentation of amino acids, peptides, DNA and silver cluster tryptophan complexes in gas phase.
In the case of peptides, the UV excitation of chromophores in the systems leads to a specific fragmentation which can be controlled by laser wavelength. The fragmentation schemes obtained after laser excitation depends on the photo-induced charge transfer and can be linked to the system's geometry.
The optical spectra of the silver cluster tryptophan complexes supported by TD-DFT calculations allow an elaborate study of the electronics excitation, charge transfer and relaxation in a hybrid metal biomolecule system.
The production and use of the radical fragment produce by photofragmentation or by photodetachment are also discussed and exemple on peptides and DNAs are further illustrated.
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https://tel.archives-ouvertes.fr/tel-00198749
Contributor : Thibault Tabarin <>
Submitted on : Monday, December 17, 2007 - 6:44:25 PM
Last modification on : Thursday, October 15, 2020 - 9:00:22 AM
Long-term archiving on: : Friday, November 25, 2016 - 8:01:33 PM

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  • HAL Id : tel-00198749, version 1

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Thibault Tabarin. Conformation et dynamique de biomolècules en phase gazeuse. Physique Atomique [physics.atom-ph]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00198749⟩

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