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Identification de motifs dans les réseaux métaboliques

Vincent Lacroix 1
1 Baobab
PEGASE - Département PEGASE [LBBE]
Abstract : This thesis lies within the scope of the structural analysis of biological networks. We propose a new definition of motif in the context of metabolic networks. A metabolic network is modelled by a coloured graph and a motif is defined as a multiset of colours (a colour corresponds to a reaction mechanism). An occurrence of a motif is defined as a set of connected nodes coloured by the colours of the motif. We propose algorithms to search for and infer such motifs, as well as a statistical criterion to decide if a motif is over-represented. The application of our methods to the metabolism of Esche- richia coli reveals repeated local structures. We argue that theses structures can be interpreted as functional and/or evolutionary blocks of metabolism.
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https://tel.archives-ouvertes.fr/tel-00195401
Contributor : Vincent Lacroix <>
Submitted on : Monday, December 10, 2007 - 5:03:01 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:05 PM
Long-term archiving on: : Monday, April 12, 2010 - 6:49:05 AM

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  • HAL Id : tel-00195401, version 1

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Vincent Lacroix. Identification de motifs dans les réseaux métaboliques. Autre [cs.OH]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00195401⟩

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