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Inflammation et infiltration monocytaire associées à la dégénérescence neuronale induite par un status epilepticus chez le rat

Abstract : Intractable temporal lobe epilepsy may be consecutive to the loss of neurons in the hippocampus. In this brain area, neurodegeneration may be induced by inflammatory processes. Using a rat model of epileptogenesis, we characterized the inflammatory response in the hippocampus, that we show to precede neurodegeneration. We evidenced a high induction of proinflammatory cytokine concentration, mainly in cells corresponding to activated microglia and to monocytes which infiltrated the hippocampal parenchyma. Degradation of heparan sulfate chains present at the surface of monocytes by neuronal heparanase may promote their progression in the brain parenchyma. Blockade of the linkage site of heparanase on heparan sulfate chains could reduce brain infiltration of monocytes and then prevent neurodegeneration associated to epilepsy.
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https://tel.archives-ouvertes.fr/tel-00195393
Contributor : Frédérique Cohen-Adad <>
Submitted on : Monday, December 10, 2007 - 4:31:07 PM
Last modification on : Thursday, November 21, 2019 - 2:27:28 AM
Long-term archiving on: : Monday, April 12, 2010 - 6:48:21 AM

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  • HAL Id : tel-00195393, version 1

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Fabrice Navarro y Garcia. Inflammation et infiltration monocytaire associées à la dégénérescence neuronale induite par un status epilepticus chez le rat. Physiologie [q-bio.TO]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00195393⟩

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