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Détection des mutations de /TP53/ et /CTNNB1/ dans l'ADN tumoral ou plasmatique : signification comme biomarqueurs de l'hépatocancérogenèse

Abstract : Hepatocellular carcinoma (HCC) is frequent in tropical regions where its diagnosis is late and its treatments are inefficient. Early diagnosis implies identification of HCC specific molecular markers which can be detectable in easily collected samples such as blood samples. In this work, we have studied the interest of mutations in /TP53/ and /CTNNB1/ genes as biomarkers for early detection and determination of HCC etiology. On one hand, we have analysed a specific mutation at codon 249 of /TP53/ gene (Ser249). We have shown that variations in concentration of Ser249 mutation in circulating DNA are a marker of exposure to aflatoxin B1 and hepatitis B virus, and that they may predict hepatocarcinogenesis. On the other hand, we have observed that mutations in /TP53/ and /CTNNB1/ genes can occur in the same HCC revealing complex mechanisms integrating the two pathways depending on etiology. Understanding these mechanisms will allow us to determine the value of mutations as molecular markers of HCC.
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https://tel.archives-ouvertes.fr/tel-00194209
Contributor : Emilie Le Roux-Goglin <>
Submitted on : Wednesday, December 5, 2007 - 11:49:51 PM
Last modification on : Friday, October 23, 2020 - 4:42:39 PM
Long-term archiving on: : Monday, April 12, 2010 - 6:21:09 AM

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  • HAL Id : tel-00194209, version 1

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Emilie Le Roux - Goglin. Détection des mutations de /TP53/ et /CTNNB1/ dans l'ADN tumoral ou plasmatique : signification comme biomarqueurs de l'hépatocancérogenèse. Biochimie [q-bio.BM]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00194209⟩

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