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Theses

Effets motivationnels de la nicotine chez le rat.
Implication des endocannabinoïdes et d'autres systèmes de neurotransmission.

Abstract : Tobacco smoking represent worldwide public health problem and nicotine is the principal component in tobacco smoke that leads to addiction. We showed that rats developed reliable and robust conditioned place preference (CPP) to a low dose of nicotine (0.06 mg/kg). Acute blockade of CB1 receptors by rimonabant, or α1-adrenoceptors by prazosin counteracts the short-term, but not the long-term expression of nicotine-CPP.
Daily administration of rimonabant during the post-acquisition period allowed an acute pre-test injection of this CB1 receptor antagonist to retain its blocking effect on the long-term expression of nicotine-induced CPP, without altering the G-protein coupling of CB1 receptors. These results indicate the development of neuroadaptative changes during the post-acquisition phase that are under the control of endocannabinoids. In addition, nicotine-CPP did not modify the functionality of CB1, D2 or 5-HT1A receptors in all structures analysed. Finally, nicotine-induced CPP was extinguished in only a part of rats after an extinction phase, and a priming dose of nicotine (0.06 mg/kg) reinstated the CPP in these animals.
In conclusions, CB1 receptors and/or α1-adrenoceptors are implicated in the motivational effects of nicotine and their blockade may be a useful therapeutic treatment for tobacco addiction.
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https://tel.archives-ouvertes.fr/tel-00194206
Contributor : Benoit Forget <>
Submitted on : Wednesday, December 5, 2007 - 11:41:06 PM
Last modification on : Friday, October 23, 2020 - 4:42:39 PM
Long-term archiving on: : Monday, April 12, 2010 - 6:19:19 AM

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  • HAL Id : tel-00194206, version 1

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Benoit Forget. Effets motivationnels de la nicotine chez le rat.
Implication des endocannabinoïdes et d'autres systèmes de neurotransmission.. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2007. Français. ⟨tel-00194206⟩

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