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Theses

Elaboration de nanoparticules d'or fonctionnalisées pour la détection et l'imagerie biologiques

Abstract : Gold nanoparticles seem to be ideal templates for immobilizing and carrying a high number of organic molecules. This property might have potential application in the field of microscopy by fluorescence and magnetic resonance imaging in order to lower the detection threshold. A study on this subject has also been launched and led to synthesis of gold nanoparticules (8-12 nm), functionnalized with several hundreds of fluorophores. A study performed on biochips demonstrated that these new luminescent nanoprobes have a real potential for the biological detection since signal is enhanced occur by two orders of magnitude. At the same time, the synthesis of gold nanoparticles (2-2.5 nm) surrounded by a multilayer of dithiolated derivatives (DTDTPA), especially stable in solution, are able to chelate gadolinium ions. MRI study of these nanoparticles reveal a significant enhancement of the contrast in comparison to DTPA:Gd.
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https://tel.archives-ouvertes.fr/tel-00194115
Contributor : Pierre-Jean Debouttière <>
Submitted on : Wednesday, December 5, 2007 - 4:50:06 PM
Last modification on : Wednesday, November 20, 2019 - 2:29:58 AM
Long-term archiving on: : Monday, April 12, 2010 - 6:15:51 AM

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  • HAL Id : tel-00194115, version 1

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Pierre-Jean Debouttière. Elaboration de nanoparticules d'or fonctionnalisées pour la détection et l'imagerie biologiques. Matériaux. Université Claude Bernard - Lyon I, 2006. Français. ⟨tel-00194115⟩

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