Skip to Main content Skip to Navigation
Theses

Bases moléculaires de la progression tumorale dans les lésions prénéoplasiques bronchiques: Approches in situ

Abstract : In order to identify in preneoplastic bronchial lesions molecular abnormalities characteristic of irrevesibility and tumoral progression, which could serve as markers for surveillance and chemoprevention of high risk patients, we have demonstrated the predictive value of cumulative molecular abnormalities in bronchial carcinogenesis. We have shown a competition between SEMA3F, lost early in carcinogensis and which gene is a candidate suppressor gene with possible proapoptotic properties, and VEGF, implicated in tumoral progression and migration, on their common recetors neuropilines 1 and 2. Furthermore, telomerase, an enzyme which maintains telomere lenght and thus enables immortality, is expressed with the highest levels in basaloid and small cell lung carcinoma. Its nuclear accumulation in non small cell lung carcinoma appears to be correlated with a worse prognosis, protecting tumor cells from an increased genetic instability. In bronchial carcinogenesis, telomerase is re activated early, preceded by telomere shortening which occurs in squamous metaplasia, and is increasingly expressed in dysplasia, along with Rb/p16 and p53 inactivation.
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00192586
Contributor : Sylvie Lantuejoul <>
Submitted on : Thursday, November 29, 2007 - 9:04:57 AM
Last modification on : Friday, November 6, 2020 - 3:46:31 AM
Long-term archiving on: : Monday, April 12, 2010 - 5:25:50 AM

Identifiers

  • HAL Id : tel-00192586, version 1

Collections

INSERM | UJF | U823 | UGA

Citation

Sylvie Lantuejoul. Bases moléculaires de la progression tumorale dans les lésions prénéoplasiques bronchiques: Approches in situ. Biochimie [q-bio.BM]. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00192586⟩

Share

Metrics

Record views

316

Files downloads

3185