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Rôle de Brm dans le contrôle du cycle cellulaire et Étude de l'équilibre prolifération/différenciation des kératinocytes

Abstract : The main regulators of the cellular proliferation are the kinases Cdk, whose activity depends on their association with the cyclins. The control of cyclin expression is the first mechanism of cell cycle regulation, that is essential for the balance proliferation/differentiation in the keratinocytes. We show that Brm, main subunit of the chromatin remodeling complexes SWI/SNF, is necessary for cyclin A repression by positioning two nucleosomes on the proximal promoter of the gene. We also demonstrate that the lack of brm leads to genomic instability by accelerating S phase and lengthening mitosis. This may be the consequence of the deregulation of the three oncogenes, c-myc, cyclin E and cyclin A. Finally, we present evidences that the keratinocytes enter differentiation after a p21 dependent cell cycle arrest in G2/M. However, differentiating keratinocytes cannot sustain this state, bypass mitosis and reenter G1 phase with a 4N DNA content.
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https://tel.archives-ouvertes.fr/tel-00192360
Contributor : Marjorie Coisy-Quivy <>
Submitted on : Tuesday, November 27, 2007 - 4:40:07 PM
Last modification on : Monday, June 11, 2018 - 4:46:01 PM
Long-term archiving on: : Monday, April 12, 2010 - 5:18:44 AM

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  • HAL Id : tel-00192360, version 1

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Marjorie Coisy-Quivy. Rôle de Brm dans le contrôle du cycle cellulaire et Étude de l'équilibre prolifération/différenciation des kératinocytes. Biologie cellulaire. Université Montpellier II - Sciences et Techniques du Languedoc, 2004. Français. ⟨tel-00192360⟩

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