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Synthèse et évalutaion de nouveaux composés organiques et phosphorés contre les effets des rayonnements ionisants. Etude de leur mécanisme d'action in vitro.

Abstract : This work falls under a research program. The aim was to synthesize new organic phosphorylated compounds having an interesting radiopharmacological activity without toxicity. That's why, we carried out the synthesis of new benzothiazole and thiadiazole N-substituted derivatives as thiols, aminothiols, acids thiosulfonic and phosphorothioates. All these compounds were characterized by NMR (proton, carbon, phosphorus, 2D), by mass spectrometry, elementary analyzes and for some of them by diffraction of x-rays. The activity of the majority of them was evaluated by in vitro tests. The experimental results were confirmed by theoretical study : the aim of DFT calculation was the study of the mechanism of capture of the free radicals by our compounds. In addition, a study of relation structure activity (QSAR) was carried out. Our results allow us to create a model making it possible to establish structure-activity relationship.
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Submitted on : Monday, November 26, 2007 - 11:31:24 AM
Last modification on : Friday, March 12, 2021 - 1:32:09 PM
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C. Prouillac. Synthèse et évalutaion de nouveaux composés organiques et phosphorés contre les effets des rayonnements ionisants. Etude de leur mécanisme d'action in vitro.. Autre. Université Paul Sabatier - Toulouse III, 2006. Français. ⟨tel-00191910⟩

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