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Etude de la dynamique et de la physique statistique de modèles d'ADN non-linéaires à la dénaturation thermique

Abstract : This work deals with the development and the analysis of the properties of new DNA models, in order to better characterize thermal denaturation. We proposed three DNA models based on finite site-dependent stacking enthalpies and showed that they correctly reproduce experimental melting curves. We next investigated the amplification of DNA temperature fluctuations at thermal denaturation and pointed out the 1/f dependence of the power spectrum of temperature fluctuations. We then performed a complete statistical analysis of the critical behaviour of homogeneous DNA models, quantitatively checked the discontinuous character of the melting transition, and showed that two scaling laws (out of four) are not satisfied. Finally, we investigated finite-size effects on the melting transition of homogeneous DNA models and tested the hypotheses on which the finite size scaling theory relies. Ongoing work aims at understanding the effects of heterogeneity on the melting transition.
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https://tel.archives-ouvertes.fr/tel-00185960
Contributor : Sahin Buyukdagli <>
Submitted on : Wednesday, November 7, 2007 - 3:55:38 PM
Last modification on : Tuesday, September 11, 2018 - 11:00:02 AM
Long-term archiving on: : Monday, September 24, 2012 - 2:56:38 PM

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Sahin Buyukdagli. Etude de la dynamique et de la physique statistique de modèles d'ADN non-linéaires à la dénaturation thermique. Biophysique [physics.bio-ph]. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00185960⟩

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