L. Abenhaim, Y. Moride, F. Brenot, S. Rich, J. Benichou et al., Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group, pp.609-616, 1996.

S. Ahlenius, K. Larsson, and L. Et-svensson, Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior, Psychopharmacology, vol.17, issue.Suppl., pp.217-220, 1980.
DOI : 10.1007/BF00428106

K. Akashi, D. Traver, T. Miyamoto, and I. L. Et-weissman, A clonogenic common myeloid progenitor that gives rise to all myeloid lineages, Nature, vol.362, issue.6774, pp.193-197, 2000.
DOI : 10.1038/35004599

L. Alberio, O. Safa, K. J. Clemetson, C. T. Esmon, and G. L. Et-dale, Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin, Blood, vol.95, pp.1694-1702, 2000.

G. M. Anderson, D. X. Freedman, D. J. Cohen, F. R. Volkmar, E. L. Hoder et al., WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS, Journal of Child Psychology and Psychiatry, vol.38, issue.6, pp.885-900, 1987.
DOI : 10.1007/BF01537926

V. Arango, Y. Y. Huang, M. D. Underwood, and J. J. Et-mann, Genetics of the serotonergic system in suicidal behavior, Journal of Psychiatric Research, vol.37, issue.5, pp.375-386, 2003.
DOI : 10.1016/S0022-3956(03)00048-7

E. C. Azmitia, Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis, International review of neurobiology, vol.77, pp.31-56, 2007.
DOI : 10.1016/S0074-7742(06)77002-7

M. Banasr, M. Hery, R. Printemps, and A. Et-daszuta, Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone, Neuropsychopharmacology, vol.29, issue.3, pp.450-460, 2004.
DOI : 10.1038/sj.npp.1300320

O. Behnke, Blood platelet heterogeneity: a functional hierarchy in the platelet population, British Journal of Haematology, vol.83, issue.4, pp.991-999, 1995.
DOI : 10.1016/0024-3205(91)90576-W

O. Behnke and A. Et-forer, Blood platelet heterogeneity: evidence for two classes of platelets in man and rat, British Journal of Haematology, vol.10, issue.4, pp.686-693, 1993.
DOI : 10.1083/jcb.91.3.706

G. Bellipanni, E. Rink, and L. Et-bally-cuif, Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain, Mechanisms of Development, vol.119, pp.215-220, 2002.
DOI : 10.1016/S0925-4773(03)00119-9

N. E. Berman, V. Puri, S. Chandrala, S. Puri, R. Macgregor et al., Serotonin in Trigeminal Ganglia of Female Rodents: Relevance to Menstrual Migraine, Headache: The Journal of Head and Face Pain, vol.51, issue.1, pp.1230-1245, 2006.
DOI : 10.1111/j.1468-2982.2004.00839.x

M. Berthouze, M. Ayoub, O. Russo, L. Rivail, S. Sicsic et al., receptors in living cells, FEBS Letters, vol.66, issue.14, pp.2973-2980, 2005.
DOI : 10.1016/j.febslet.2005.04.040

M. Bianchi, C. Moser, C. Lazzarini, E. Vecchiato, and F. Et-crespi, Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes, Experimental Brain Research, vol.143, issue.2, pp.191-197, 2002.
DOI : 10.1007/s00221-001-0979-3

P. Bianchi, D. R. Pimentel, M. P. Murphy, W. S. Colucci, and A. Et-parini, A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation, The FASEB Journal, vol.19, pp.641-643, 2005.
DOI : 10.1096/fj.04-2518fje

J. Bockaert, S. Claeysen, C. Becamel, A. Dumuis, and P. Et-marin, Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation, Cell and Tissue Research, vol.82, issue.2, pp.553-572, 2006.
DOI : 10.1007/s00441-006-0286-1

S. Boularand, Etude du gène de la tryptophane hydroxylase humaine, 1994.

S. Boularand, M. C. Darmon, and J. Et-mallet, The human tryptophan hydroxylase gene. An unusual splicing complexity in the 5'-untranslated region, The Journal of biological chemistry, vol.270, pp.3748-3756, 1995.

S. Boularand, M. C. Darmon, P. Ravassard, and J. Et-mallet, Characterization of the human tryptophan hydroxylase gene promoter. Transcriptional regulation by cAMP requires a new motif distinct from the cAMP-responsive element, The Journal of biological chemistry, vol.270, pp.3757-3764, 1995.

P. B. Bradley, G. Engel, W. Feniuk, J. R. Fozard, P. P. Humphrey et al., Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine, Neuropharmacology, vol.25, issue.6, pp.563-576, 1986.
DOI : 10.1016/0028-3908(86)90207-8

T. Brattelid, E. Qvigstad, J. A. Lynham, P. Molenaar, H. Aass et al., Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.370, issue.3, pp.157-166, 2004.
DOI : 10.1007/s00210-004-0963-0

K. Bruck and P. Et-hinckel, Thermoregulatory noradrenergic and serotonergic pathways to hypothalamic units, The Journal of Physiology, vol.304, issue.1, pp.193-202, 1980.
DOI : 10.1113/jphysiol.1980.sp013319

A. Calas, G. Alonso, E. Arnauld, and J. D. Vincent, Demonstration of indolaminergic fibres in the median eminence of the duck, rat and monkey, Nature, vol.147, issue.5463, pp.241-243, 1974.
DOI : 10.1038/250241a0

J. Callebert, J. M. Esteve, P. Herve, K. Peoc-'h, C. Tournois et al., Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice, Journal of Pharmacology and Experimental Therapeutics, vol.317, issue.2, pp.724-731, 2006.
DOI : 10.1124/jpet.105.098269

URL : https://hal.archives-ouvertes.fr/hal-01274937

J. L. Carrasco and C. Et-sandner, Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview, International Journal of Clinical Practice, vol.61, issue.Suppl. 8, pp.1428-1434, 2005.
DOI : 10.1111/j.1368-5031.2005.00681.x

L. Cervo, A. Canetta, E. Calcagno, S. Burbassi, G. Sacchetti et al., Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression, Journal of Neuroscience, vol.25, issue.36, pp.8165-8172, 2005.
DOI : 10.1523/JNEUROSCI.1816-05.2005

F. Chaouloff, Serotonin, stress and corticoids, Journal of Psychopharmacology, vol.14, issue.2, pp.139-151, 2000.
DOI : 10.1177/026988110001400203

J. Chen and K. R. Et-chien, Complexity in simplicity: monogenic disorders and complex cardiomyopathies, Journal of Clinical Investigation, vol.103, issue.11, pp.1483-1485, 1999.
DOI : 10.1172/JCI7297

D. S. Choi and L. Et-maroteaux, Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain, FEBS Letters, vol.54, issue.1-2, pp.45-51, 1996.
DOI : 10.1016/0014-5793(96)00695-3

D. S. Choi, S. J. Ward, N. Messaddeq, J. M. Launay, and L. Et-maroteaux, 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells, Development, vol.124, pp.1745-1755, 1997.

A. J. Chruscinski, D. K. Rohrer, E. Schauble, K. H. Desai, D. Bernstein et al., Targeted Disruption of the beta 2 Adrenergic Receptor Gene, Journal of Biological Chemistry, vol.274, issue.24, pp.16694-16700, 1999.
DOI : 10.1074/jbc.274.24.16694

M. D. Coates, C. R. Mahoney, D. R. Linden, J. E. Sampson, J. Chen et al., Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ???, Gastroenterology, vol.126, issue.7, pp.1657-1664, 2004.
DOI : 10.1053/j.gastro.2004.03.013

C. M. Coleman and W. S. Et-neckameyer, Serotonin synthesis by two distinct enzymes in Drosophila melanogaster. Archives of insect biochemistry and physiology 59, pp.12-31, 2005.

H. M. Connolly, J. L. Crary, M. D. Mcgoon, D. D. Hensrud, B. S. Edwards et al., Valvular Heart Disease Associated with Fenfluramine???Phentermine, New England Journal of Medicine, vol.337, issue.9, pp.581-588, 1997.
DOI : 10.1056/NEJM199708283370901

S. L. Connors, K. J. Matteson, G. A. Sega, C. B. Lozzio, R. C. Carroll et al., Plasma Serotonin in Autism, Pediatric Neurology, vol.35, issue.3, pp.182-186, 2006.
DOI : 10.1016/j.pediatrneurol.2006.02.010

M. Costa, J. B. Furness, A. C. Cuello, A. A. Verhofstad, H. W. Steinbusch et al., Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their visualization and reactions to drug treatment, Neuroscience, vol.7, issue.2, pp.351-363, 1982.
DOI : 10.1016/0306-4522(82)90272-X

F. Cote, C. Fligny, E. Bayard, J. M. Launay, M. D. Gershon et al., From the Cover: Maternal serotonin is crucial for murine embryonic development, Proceedings of the National Academy of Sciences of the United States of America, pp.329-334, 2007.

F. Cote, C. Fligny, Y. Fromes, J. Mallet, and G. Et-vodjdani, Recent advances in understanding serotonin regulation of cardiovascular function, Trends in Molecular Medicine, vol.10, issue.5, pp.232-238, 2004.
DOI : 10.1016/j.molmed.2004.03.007

F. Cote, N. Schussler, S. Boularand, A. Peirotes, E. Thevenot et al., Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH) gene in the pineal gland, Journal of Neurochemistry, vol.6, issue.4, pp.673-685, 2002.
DOI : 10.1046/j.1471-4159.2002.00890.x

F. Cote, E. Thevenot, C. Fligny, Y. Fromes, M. Darmon et al., Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function, Proceedings of the National Academy of Sciences of the United States of America, pp.13525-13530, 2003.
DOI : 10.1073/pnas.2233056100

P. J. Cowen, I. M. Anderson, and S. E. Et-gartside, Endocrinological Responses to 5-HT, Annals of the New York Academy of Sciences, vol.12, issue.1 The Neurophar, pp.250-257, 1990.
DOI : 10.1016/0006-3223(89)90024-3

P. J. Cowen and A. J. Et-wood, Biological markers in depression, Current Opinion in Psychiatry, vol.2, issue.1, pp.831-836, 1991.
DOI : 10.1097/00001504-198902000-00025

S. P. Craig, V. J. Buckle, A. Lamouroux, J. Mallet, and I. Et-craig, Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways, Cytogenetic and Genome Research, vol.42, issue.1-2, pp.29-32, 1986.
DOI : 10.1159/000132246

M. D. Crowell, Role of serotonin in the pathophysiology of the irritable bowel syndrome, British Journal of Pharmacology, vol.43, issue.Suppl II, pp.1285-1293, 2004.
DOI : 10.1038/sj.bjp.0705762

J. J. Crowley, J. A. Blendy, and I. Et-lucki, Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test, Psychopharmacology, vol.305, issue.Suppl 30, pp.257-264, 2005.
DOI : 10.1007/s00213-005-0166-5

G. Curzon, Serotonin and Appetite, Annals of the New York Academy of Sciences, vol.48, issue.1 The Neurophar, pp.521-530, 1990.
DOI : 10.1016/0024-3205(86)90112-8

A. Dahlstrom and K. Et-fuxe, Localization of monoamines in the lower brain stem, Experientia, vol.56, issue.Suppl., pp.398-399, 1964.
DOI : 10.1007/BF02147990

G. L. Dale, Coated-platelets: an emerging component of the procoagulant response, Journal of Thrombosis and Haemostasis, vol.84, issue.Suppl. 1, pp.2185-2192, 2005.
DOI : 10.1111/j.1538-7836.2005.01274.x

G. L. Dale, P. Friese, P. Batar, S. F. Hamilton, G. L. Reed et al., Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface, Nature, vol.415, issue.6868, pp.175-179, 2002.
DOI : 10.1038/415175a

M. C. Darmon, B. Grima, C. D. Cash, M. Maitre, and J. Et-mallet, Isolation of a rat pineal gland cDNA clone homologous to tyrosine and phenylalanine hydroxylases, FEBS Letters, vol.74, issue.1, pp.43-46, 1986.
DOI : 10.1016/0014-5793(86)81337-0

M. C. Darmon, B. Guibert, V. Leviel, M. Ehret, M. Maitre et al., Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase, Journal of Neurochemistry, vol.2, issue.1, pp.312-316, 1988.
DOI : 10.1073/pnas.82.4.1074

A. Daszuta and P. Et-portalier, Distribution and quantification of 5-HT nerve cell bodies in the nucleus raphe dorsalis area of C57BL and BALBc mice. Relationship between anatomy and biochemistry, Brain Research, vol.360, issue.1-2, pp.58-64, 1985.
DOI : 10.1016/0006-8993(85)91220-X

M. W. Decker and J. L. Et-mcgaugh, The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory, Synapse, vol.28, issue.2, pp.151-168, 1991.
DOI : 10.1002/syn.890070209

L. Descarries, M. A. Audet, G. Doucet, S. Garcia, S. Oleskevich et al., Morphology of Central Serotonin Neurons., Annals of the New York Academy of Sciences, vol.394, issue.1 The Neurophar, pp.81-92, 1990.
DOI : 10.1016/0006-8993(85)90857-1

L. Descarries, K. C. Watkins, S. Garcia, and A. Beaudet, The serotonin neurons in nucleus raphe dorsalis of adult rat: A light and electron microscope radioautographic study, The Journal of Comparative Neurology, vol.62, issue.3, pp.239-254, 1982.
DOI : 10.1002/cne.902070305

R. B. Devereux, Appetite Suppressants and Valvular Heart Disease, New England Journal of Medicine, vol.339, issue.11, pp.765-766, 1998.
DOI : 10.1056/NEJM199809103391109

D. Lieto, A. Leo, D. Volpicelli, F. Di-porzio, U. Et-colucci-d-'amato et al., FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc, Brain Research, vol.1143, 2007.
DOI : 10.1016/j.brainres.2007.01.076

R. A. Dixon, B. K. Kobilka, D. J. Strader, J. L. Benovic, H. G. Dohlman et al., Cloning of the gene and cDNA for mammalian ??-adrenergic receptor and homology with rhodopsin, Nature, vol.25, issue.6065, pp.75-79, 1986.
DOI : 10.1038/321075a0

C. F. Dreyfus and M. B. Et-bornstein, Synthesis of serotonin by neurons of the myenteric plexus in situ and in organotypic tissue culture, Brain Research, vol.128, issue.1, pp.125-139, 1977.
DOI : 10.1016/0006-8993(77)90240-2

S. Dumas, M. C. Darmon, J. Delort, and J. Et-mallet, Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: Evidence for a role of translation efficiency, Journal of Neuroscience Research, vol.23, issue.4, pp.537-547, 1989.
DOI : 10.1002/jnr.490240412

S. Eddahibi, V. Fabre, C. Boni, M. P. Martres, B. Raffestin et al., Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells : Relationship With the Mitogenic Action of Serotonin, Circulation Research, vol.84, issue.3, pp.329-336, 1999.
DOI : 10.1161/01.RES.84.3.329

S. Eddahibi, C. Guignabert, A. M. Barlier-mur, L. Dewachter, E. Fadel et al., Cross Talk Between Endothelial and Smooth Muscle Cells in Pulmonary Hypertension: Critical Role for Serotonin-Induced Smooth Muscle Hyperplasia, Circulation, vol.113, issue.15, pp.1857-1864, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.591321

S. Eddahibi, N. Hanoun, L. Lanfumey, K. P. Lesch, B. Raffestin et al., Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene, Journal of Clinical Investigation, vol.105, issue.11, pp.1555-1562, 2000.
DOI : 10.1172/JCI8678

R. M. Eglen, J. R. Jasper, D. J. Chang, and G. R. Et-martin, The 5-HT7 receptor: orphan found, Trends in Pharmacological Sciences, vol.18, issue.4, pp.104-107, 1997.
DOI : 10.1016/S0165-6147(97)01043-2

J. D. Erickson, L. E. Eiden, and B. J. Et-hoffman, Expression cloning of a reserpine-sensitive vesicular monoamine transporter., Proceedings of the National Academy of Sciences, vol.89, issue.22, pp.10993-10997, 1992.
DOI : 10.1073/pnas.89.22.10993

V. Erspamer and B. Et-asero, Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine, Nature, vol.180, issue.4306, pp.800-801, 1952.
DOI : 10.1021/ja01154a551

V. Erspamer and M. Et-vialli, Ricerche sul secreto delle cellule enterocromaffini, Boll d Soc Med-chir Pavia, vol.51, pp.357-363, 1937.

J. M. Esteve, J. M. Launay, O. Kellermann, and L. Et-maroteaux, Functions of serotonin in hypoxic pulmonary vascular remodeling, Cell Biochemistry and Biophysics, vol.173, issue.Suppl, pp.33-44, 2007.
DOI : 10.1385/CBB:47:1:33

URL : https://hal.archives-ouvertes.fr/hal-01274919

B. L. Fanburg and S. L. Et-lee, A new role for an old molecule: serotonin as a mitogen, The American journal of physiology, vol.272, pp.795-806, 1997.

A. Fargin, J. R. Raymond, M. J. Lohse, B. K. Kobilka, M. G. Caron et al., The genomic clone G-21 which resembles a ??-adrenergic receptor sequence encodes the 5-HT1A receptor, Nature, vol.335, issue.6188, pp.358-360, 1988.
DOI : 10.1038/335358a0

L. W. Fitzgerald, T. C. Burn, B. S. Brown, J. P. Patterson, M. H. Corjay et al., Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine, Molecular pharmacology, vol.57, pp.75-81, 2000.

P. F. Fitzpatrick, Tetrahydropterin-Dependent Amino Acid Hydroxylases, Annual Review of Biochemistry, vol.68, issue.1, pp.355-381, 1999.
DOI : 10.1146/annurev.biochem.68.1.355

D. J. Fox and R. S. Et-khattar, Carcinoid heart disease: presentation, diagnosis, and management, Heart, vol.90, issue.10, pp.1224-1228, 2004.
DOI : 10.1136/hrt.2004.040329

L. W. Fu and J. C. Et-longhurst, receptors, The Journal of Physiology, vol.47, issue.4A, pp.897-912, 2002.
DOI : 10.1113/jphysiol.2002.023374

URL : https://hal.archives-ouvertes.fr/hal-00376085

L. W. Fu and J. C. Et-longhurst, Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats, American journal of physiology, vol.282, pp.100-109, 2002.

J. B. Furness and M. Et-costa, Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their projections in the guinea-pig small intestine, Neuroscience, vol.7, issue.2, pp.341-349, 1982.
DOI : 10.1016/0306-4522(82)90271-8

J. H. Gaddum and Z. P. Et-picarelli, TWO KINDS OF TRYPTAMINE RECEPTOR, British Journal of Pharmacology and Chemotherapy, vol.12, issue.3, pp.323-328, 1957.
DOI : 10.1111/j.1476-5381.1957.tb00142.x

P. Gaspar, O. Cases, and L. Et-maroteaux, The developmental role of serotonin: news from mouse molecular genetics, Nature Reviews Neuroscience, vol.17, issue.12, pp.1002-1012, 2003.
DOI : 10.1038/nrn1256

URL : https://hal.archives-ouvertes.fr/hal-01274960

M. D. Gershon, The Enteric Nervous System: A Second Brain, Hospital Practice, vol.22, issue.7, pp.31-32, 1999.
DOI : 10.3810/hp.1999.07.153

M. D. Gershon and R. F. Et-altman, An analysis of the uptake of 5-hydroxytryptamine by the myenteric plexus of the small intestine of the guinea pig, The Journal of pharmacology and experimental therapeutics, vol.179, pp.29-41, 1971.

M. D. Gershon, A. B. Drakontides, and L. L. Et-ross, Serotonin: Synthesis and Release from the Myenteric Plexus of the Mouse Intestine, Science, vol.149, issue.3680, pp.197-199, 1965.
DOI : 10.1126/science.149.3680.197

M. D. Gershon and G. M. Et-jonakait, UPTAKE AND RELEASE OF 5-HYDROXYTRYPTAMINE BY ENTERIC 5-HYDROXYTRYPTAMINERGIC NEURONES: EFFECTS OF FLUOXETINE (LILLY 110140) AND CHLORIMIPRAMINE, British Journal of Pharmacology, vol.15, issue.1, pp.7-9, 1979.
DOI : 10.1111/j.1476-5381.1979.tb16089.x

M. D. Gershon, R. G. Robinson, and L. L. Et-ross, Serotonin accumulation in the guinea-pig myenteric plexus: ion dependence, structure-activity relationship and the effect of drugs, The Journal of pharmacology and experimental therapeutics, vol.198, pp.548-561, 1976.

M. D. Gershon and L. L. Et-ross, Location of sites of 5-hydroxytryptamine storage and metabolism by radioautography, The Journal of Physiology, vol.186, issue.2, pp.477-492, 1966.
DOI : 10.1113/jphysiol.1966.sp008047

M. D. Gershon and L. L. Et-ross, Radioisotopic studies of the binding, exchange, and distribution of 5-hydroxytryptamine synthesized from its radioactivity precursor, The Journal of Physiology, vol.186, issue.2, pp.451-476, 1966.
DOI : 10.1113/jphysiol.1966.sp008046

M. D. Gershon and J. Et-tack, The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders, Gastroenterology, vol.132, issue.1, pp.397-414, 2007.
DOI : 10.1053/j.gastro.2006.11.002

A. Ghozlan and A. Et-munnich, [MAOB: a modifier gene in phenylketonuria?, Med Sci, vol.20, pp.929-932, 2004.

C. E. Glatt, E. Carlson, T. R. Taylor, N. Risch, V. I. Reus et al., Response to loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression, Neuron Neuron, vol.45, issue.48, pp.11-16, 2005.

H. E. Grenett, F. D. Ledley, L. L. Reed, and S. L. Et-woo, Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases., Proceedings of the National Academy of Sciences of the United States of America, pp.5530-5534, 1987.
DOI : 10.1073/pnas.84.16.5530

B. I. Gustafsson, L. Thommesen, A. K. Stunes, K. Tommeras, I. Westbroek et al., Serotonin and fluoxetine modulate bone cell function in vitro, Journal of Cellular Biochemistry, vol.276, issue.1, pp.139-151, 2006.
DOI : 10.1002/jcb.20734

B. I. Gustafsson, K. Tommeras, I. Nordrum, J. P. Loennechen, A. Brunsvik et al., Long-Term Serotonin Administration Induces Heart Valve Disease in Rats, Circulation, vol.111, issue.12, pp.1517-1522, 2005.
DOI : 10.1161/01.CIR.0000159356.42064.48

G. Halliday, J. Ellis, R. Heard, D. Caine, and C. Et-harper, Brainstem Serotonergic Neurons in Chronic Alcoholics With and Without the Memory Impairment of Korsakoff??s Psychosis, Journal of Neuropathology and Experimental Neurology, vol.52, issue.6, pp.567-579, 1993.
DOI : 10.1097/00005072-199311000-00003

S. L. Handley, 5-Hydroxytryptamine pathways in anxiety and its treatment, Pharmacology & Therapeutics, vol.66, issue.1, pp.103-148, 1995.
DOI : 10.1016/0163-7258(95)00004-Z

P. Harris, H. W. Fritts, . Jr, and A. Et-cournand, Some Circulatory Effects of 5-Hydroxytryptamine in Man, Circulation, vol.21, issue.6, pp.1134-1139, 1960.
DOI : 10.1161/01.CIR.21.6.1134

J. W. Haycock, S. C. Kumer, D. A. Lewis, K. E. Vrana, and C. A. Et-stockmeier, A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope, Journal of Neuroscience Methods, vol.114, issue.2, pp.205-212, 2002.
DOI : 10.1016/S0165-0270(01)00530-1

T. J. Hendricks, D. V. Fyodorov, L. J. Wegman, N. B. Lelutiu, E. A. Pehek et al., Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior, Neuron, vol.37, issue.2, pp.233-247, 2003.
DOI : 10.1016/S0896-6273(02)01167-4

K. Herrick-davis, E. Grinde, T. J. Harrigan, and J. E. Et-mazurkiewicz, Inhibition of Serotonin 5-Hydroxytryptamine2C Receptor Function through Heterodimerization: RECEPTOR DIMERS BIND TWO MOLECULES OF LIGAND AND ONE G-PROTEIN, Journal of Biological Chemistry, vol.280, issue.48, pp.40144-40151, 2005.
DOI : 10.1074/jbc.M507396200

P. Herve, J. M. Launay, M. L. Scrobohaci, F. Brenot, G. Simonneau et al., Increased plasma serotonin in primary pulmonary hypertension. The American journal of medicine 99, pp.249-254, 1995.

F. Hery and M. Et-hamon, [Neuroleptics and serotonin], Encephale, vol.19, pp.525-532, 1993.

A. J. Hill, H. Teraoka, W. Heideman, and R. E. Et-peterson, Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity, Toxicological Sciences, vol.86, issue.1, pp.6-19, 2005.
DOI : 10.1093/toxsci/kfi110

W. Hollander, A. L. Michelson, and R. W. Et-wilkins, Serotonin and Antiserotonins: I. Their Circulatory, Respiratory, and Renal Effects in Man, Circulation, vol.16, issue.2, pp.246-255, 1957.
DOI : 10.1161/01.CIR.16.2.246

M. Holtje, S. Winter, D. Walther, I. Pahner, H. Hortnagl et al., The Vesicular Monoamine Content Regulates VMAT2 Activity through G??q in Mouse Platelets: EVIDENCE FOR AUTOREGULATION OF VESICULAR TRANSMITTER UPTAKE, Journal of Biological Chemistry, vol.278, issue.18, pp.15850-15858, 2003.
DOI : 10.1074/jbc.M212816200

M. Hoshijima and K. R. Et-chien, Mixed signals in heart failure: cancer rules, Journal of Clinical Investigation, vol.109, issue.7, pp.849-855, 2002.
DOI : 10.1172/JCI15380DS1

M. Hoshijima, V. P. Sah, Y. Wang, K. R. Chien, and J. H. Et-brown, The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes. INVOLVEMENT OF Rho KINASE, Journal of Biological Chemistry, vol.273, issue.13, pp.7725-7730, 1998.
DOI : 10.1074/jbc.273.13.7725

D. Hoyer, D. E. Clarke, J. R. Fozard, P. R. Hartig, G. R. Martin et al., International Union of Pharmacology classification of receptors for 5- hydroxytryptamine (Serotonin), Pharmacol Rev, vol.46, pp.157-203, 1994.

D. Hoyer, J. P. Hannon, and G. R. Et-martin, Molecular, pharmacological and functional diversity of 5-HT receptors, Pharmacology Biochemistry and Behavior, vol.71, issue.4, pp.533-554, 2002.
DOI : 10.1016/S0091-3057(01)00746-8

A. Ichiyama, H. Hasegawa, C. Tohyama, C. Dohmoto, and T. Et-kataoka, Some properties of bovine pineal tryptophan hydroxylase Advances in experimental medicine and biology 74, pp.103-117, 1976.

K. Ishimura, Y. Takeuchi, K. Fujiwara, M. Tominaga, H. Yoshioka et al., Quantitative analysis of the distribution of serotonin-immunoreactive cell bodies in the mouse brain, Neuroscience Letters, vol.91, issue.3, pp.265-270, 1988.
DOI : 10.1016/0304-3940(88)90691-X

B. L. Jacobs and E. C. Et-azmitia, Structure and function of the brain serotonin system, Physiological reviews, vol.72, pp.165-229, 1992.

B. L. Jacobs and C. A. Et-fornal, Activity of Serotonergic Neurons in Behaving Animals, Neuropsychopharmacology, vol.21, issue.2, pp.9-15, 1999.
DOI : 10.1016/S0893-133X(99)00012-3

F. Jaffre, J. Callebert, A. Sarre, N. Etienne, C. G. Nebigil et al., Involvement of the Serotonin 5-HT2B Receptor in Cardiac Hypertrophy Linked to Sympathetic Stimulation: Control of Interleukin-6, Interleukin-1??, and Tumor Necrosis Factor-?? Cytokine Production by Ventricular Fibroblasts, Circulation, vol.110, issue.8, pp.969-974, 2004.
DOI : 10.1161/01.CIR.0000139856.20505.57

URL : https://hal.archives-ouvertes.fr/hal-01274954

J. W. Jahng, T. A. Houpt, T. C. Wessel, K. Chen, J. C. Shih et al., Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization, Synapse, vol.25, issue.1, pp.30-36, 1997.
DOI : 10.1002/(SICI)1098-2396(199701)25:1<30::AID-SYN4>3.0.CO;2-G

H. Jick, C. Vasilakis, L. A. Weinrauch, C. R. Meier, S. S. Jick et al., A Population-Based Study of Appetite-Suppressant Drugs and the Risk of Cardiac-Valve Regurgitation, New England Journal of Medicine, vol.339, issue.11, pp.719-724, 1998.
DOI : 10.1056/NEJM199809103391102

B. J. Jones and T. P. Et-blackburn, The medical benefit of 5-HT research, Pharmacology Biochemistry and Behavior, vol.71, issue.4, pp.555-568, 2002.
DOI : 10.1016/S0091-3057(01)00745-6

M. Jouvet, Sleep and serotonin: an unfinished story, Neuropsychopharmacology, vol.21, pp.24-27, 1999.

T. A. Kalfa, S. Pushkaran, N. Mohandas, J. H. Hartwig, V. M. Fowler et al., Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton, Blood, vol.108, issue.12, pp.3637-3645, 2006.
DOI : 10.1182/blood-2006-03-005942

A. J. Kaumann, Do human atrial 5-HT4 receptors mediate arrhythmias? Trends in pharmacological sciences 15, pp.451-455, 1994.

A. J. Kaumann and F. O. Et-levy, 5-Hydroxytryptamine receptors in the human cardiovascular system, Pharmacology & Therapeutics, vol.111, issue.3, pp.674-706, 2006.
DOI : 10.1016/j.pharmthera.2005.12.004

A. J. Kaumann, J. A. Lynham, and A. M. Et-brown, Comparison of the densities of 5-HT4 receptors, beta 1-and beta 2-adrenoceptors in human atrium: functional implications. Naunyn-Schmiedeberg's archives of pharmacology 353, pp.592-595, 1996.

A. J. Kaumann, L. Sanders, A. M. Brown, K. J. Murray, and M. J. Et-brown, A 5-hydroxytryptamine receptor in human atrium, British Journal of Pharmacology, vol.327, issue.Suppl. B, pp.879-885, 1990.
DOI : 10.1111/j.1476-5381.1990.tb14108.x

A. Keegan, I. Morecroft, D. Smillie, M. N. Hicks, and M. R. Et-maclean, Contribution of the 5-HT1B Receptor to Hypoxia-Induced Pulmonary Hypertension: Converging Evidence Using 5-HT1B-Receptor Knockout Mice and the 5-HT1B/1D-Receptor Antagonist GR127935, Circulation Research, vol.89, issue.12, pp.1231-1239, 2001.
DOI : 10.1161/hh2401.100426

A. L. Killam and M. L. Et-cohen, Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: Ketanserin and SCH 23390, Thrombosis Research, vol.64, issue.3, pp.331-340, 1991.
DOI : 10.1016/0049-3848(91)90004-G

K. S. Kim, T. C. Wessel, D. M. Stone, C. H. Carver, T. H. Joh et al., Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons, Brain Res Mol Brain Res, vol.9, pp.277-283, 1991.

B. K. Koe and A. Et-weissman, p-Chlorophenylalanine: a specific depletor of brain serotonin, The Journal of pharmacology and experimental therapeutics, vol.154, pp.499-516, 1966.

S. T. Koury, M. J. Koury, and M. C. Et-bondurant, Cytoskeletal distribution and function during the maturation and enucleation of mammalian erythroblasts, The Journal of Cell Biology, vol.109, issue.6, pp.3005-3013, 1989.
DOI : 10.1083/jcb.109.6.3005

M. H. Kulke and R. J. Et-mayer, Carcinoid Tumors, New England Journal of Medicine, vol.340, issue.11, pp.858-868, 1999.
DOI : 10.1056/NEJM199903183401107

J. M. Lauder and H. Et-krebs, Serotonin as a Differentiation Signal in Early Neurogenesis, Developmental Neuroscience, vol.1, issue.1, pp.15-30, 1978.
DOI : 10.1159/000112549

J. M. Launay, P. Ferrari, M. Haimart, C. Bursztejn, F. Tabuteau et al., Serotonin Metabolism and Other Biochemical Parameters in Infantile Autism, Neuropsychobiology, vol.20, issue.1, pp.1-11, 1988.
DOI : 10.1159/000118465

J. M. Launay, P. Herve, K. Peoc-'h, C. Tournois, J. Callebert et al., Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension, Nature Medicine, vol.13, issue.10, pp.1129-1135, 2002.
DOI : 10.1038/76282

M. Leboyer, A. Philippe, M. Bouvard, M. Guilloud-bataille, D. Bondoux et al., Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives, Biological Psychiatry, vol.45, issue.2, pp.158-163, 1999.
DOI : 10.1016/S0006-3223(97)00532-5

F. Lechin, B. Van-der-dijs, B. Orozco, M. Lechin, and A. E. Et-lechin, Increased Levels of Free Serotonin in Plasma of Symptomatic Asthmatic Patients, Annals of Allergy, Asthma & Immunology, vol.77, issue.3, pp.245-253, 1996.
DOI : 10.1016/S1081-1206(10)63263-2

D. H. Lemessurier, C. J. Schwartz, and R. F. Et-whelan, CARDIOVASCULAR EFFECTS OF INTRAVENOUS INFUSIONS OF 5-HYDROXYTRYPTAMINE IN MAN, British Journal of Pharmacology and Chemotherapy, vol.118, issue.2, pp.246-250, 1959.
DOI : 10.1111/j.1476-5381.1959.tb01393.x

K. P. Lesch and L. Et-gutknecht, Pharmacogenetics of the serotonin transporter, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.29, issue.6, pp.1062-1073, 2005.
DOI : 10.1016/j.pnpbp.2005.03.012

F. Lezoualc-'h, K. Steplewski, L. Sartiani, A. Mugelli, R. Fischmeister et al., Quantitative mRNA analysis of serotonin 5-HT(4) receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation, pp.218-224, 2007.

Y. Liu and B. L. Et-fanburg, Serotonin-Induced Growth of Pulmonary Artery Smooth Muscle Requires Activation of Phosphatidylinositol 3-Kinase/Serine-Threonine Protein Kinase B/Mammalian Target of Rapamycin/p70 Ribosomal S6 Kinase 1, American Journal of Respiratory Cell and Molecular Biology, vol.34, issue.2, pp.182-191, 2006.
DOI : 10.1165/rcmb.2005-0163OC

Y. Liu, D. Peter, A. Roghani, S. Schuldiner, G. G. Prive et al., A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter, Cell, vol.70, issue.4, pp.539-551, 1992.
DOI : 10.1016/0092-8674(92)90425-C

Y. Liu, Y. J. Suzuki, R. M. Day, and B. L. Et-fanburg, Rho Kinase-Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin, Circulation Research, vol.95, issue.6, pp.579-586, 2004.
DOI : 10.1161/01.RES.0000141428.53262.a4

S. Loric, J. M. Launay, J. F. Colas, and L. Et-maroteaux, New mouse 5-HT2-like receptor Expression in brain, heart and intestine, FEBS Letters, vol.11, issue.2-3, pp.203-207, 1992.
DOI : 10.1016/0014-5793(92)80936-B

P. H. Lowy, G. Keighley, and N. S. Et-cohen, Stimulation by Serotonin of Erythropoietin-dependent Erythropoiesis in Mice, British Journal of Haematology, vol.24, issue.6, pp.711-718, 1970.
DOI : 10.1016/0006-3002(59)90407-X

I. Lucki, A. Dalvi, and A. J. Et-mayorga, Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice, Psychopharmacology, vol.155, issue.3, pp.315-322, 2001.
DOI : 10.1007/s002130100694

J. M. Luque, S. W. Kwan, C. W. Abell, M. Da-prada, and J. G. Et-richards, Cellular expression of mRNAs encoding monoamine oxidases A and B in the rat central nervous system, The Journal of Comparative Neurology, vol.3, issue.4, pp.665-680, 1995.
DOI : 10.1002/cne.903630410

Z. S. Malek, H. Dardente, P. Pevet, and S. Et-raison, Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles, European Journal of Neuroscience, vol.305, issue.4, pp.895-901, 2005.
DOI : 10.1111/j.1460-9568.2005.04264.x

URL : https://hal.archives-ouvertes.fr/hal-00093864

Z. S. Malek, P. Pevet, and S. Et-raison, Circadian change in tryptophan hydroxylase protein levels within the rat intergeniculate leaflets and raphe nuclei, Neuroscience, vol.125, issue.3, pp.749-758, 2004.
DOI : 10.1016/j.neuroscience.2004.01.031

J. J. Mann, Role of the Serotonergic System in the Pathogenesis of Major Depression and Suicidal Behavior, Neuropsychopharmacology, vol.21, issue.2, pp.99-105, 1999.
DOI : 10.1016/S0893-133X(99)00040-8

E. Marcos, E. Fadel, O. Sanchez, M. Humbert, P. Dartevelle et al., Serotonin-Induced Smooth Muscle Hyperplasia in Various Forms of Human Pulmonary Hypertension, Circulation Research, vol.94, issue.9, pp.1263-1270, 2004.
DOI : 10.1161/01.RES.0000126847.27660.69

M. Matsuda, T. Imaoka, A. J. Vomachka, G. A. Gudelsky, Z. Hou et al., Serotonin Regulates Mammary Gland Development via an Autocrine-Paracrine Loop, Developmental Cell, vol.6, issue.2, pp.193-203, 2004.
DOI : 10.1016/S1534-5807(04)00022-X

URL : http://doi.org/10.1016/s1534-5807(04)00022-x

E. Maurer-spurej, Circulating serotonin in vertebrates, Cellular and Molecular Life Sciences, vol.62, issue.16, pp.1881-1889, 2005.
DOI : 10.1007/s00018-005-5149-5

E. Maurer-spurej, Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection, CMLS Cellular and Molecular Life Sciences, vol.62, issue.2, pp.159-170, 2005.
DOI : 10.1007/s00018-004-4262-1

J. Mckinney, P. M. Knappskog, and J. Et-haavik, Different properties of the central and peripheral forms of human tryptophan hydroxylase, Journal of Neurochemistry, vol.41, issue.2, pp.311-320, 2005.
DOI : 10.1126/science.1097540

J. L. Meek and N. H. Et-neff, TRYPTOPHAN 5-HYDROXYLASE: APPROXIMATION OF HALF-LIFE AND RATE OF AXONAL TRANSPORT, Journal of Neurochemistry, vol.155, issue.217, pp.1519-1525, 1972.
DOI : 10.1111/j.1471-4159.1972.tb05096.x

H. Y. Meltzer, The Role of Serotonin in Schizophrenia and the Place of Serotonin-Dopamine Antagonist Antipsychotics, Journal of Clinical Psychopharmacology, vol.15, pp.2-3, 1995.
DOI : 10.1097/00004714-199502001-00001

E. Mietkiewski, B. Kosmicki, and W. Et-mizgiert, On erythropoietic activity of serotonin in rabbits, Proceedings of the 24th International Congress of Physiological Sciences, p.294, 1968.

H. Mongue-din, A. Salmon, M. Y. Fiszman, and Y. Et-fromes, Non-invasive restrained ECG recording in conscious small rodents: a new tool for cardiac electrical activity investigation, Pfl??gers Archiv - European Journal of Physiology, vol.45, issue.1, 2007.
DOI : 10.1007/s00424-006-0197-8

S. Moniotte, J. L. Vaerman, M. M. Kockx, D. Larrouy, D. Langin et al., Real-time RT-PCR for the Detection of Beta-adrenoceptor Messenger RNAs in Small Human Endomyocardial Biopsies, Journal of Molecular and Cellular Cardiology, vol.33, issue.12, pp.2121-2133, 2001.
DOI : 10.1006/jmcc.2001.1475

I. Morecroft, Y. Dempsie, M. Bader, D. J. Walther, K. Kotnik et al., Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension, Hypertension, vol.49, issue.1, pp.232-236, 2007.
DOI : 10.1161/01.HYP.0000252210.58849.78

A. Morimoto, H. Hasegawa, H. J. Cheng, W. C. Little, and C. P. Et-cheng, Endogenous beta3- adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure, American journal of physiology, vol.286, pp.2425-2433, 2004.

S. Musunuru, J. E. Carpenter, R. S. Sippel, M. Kunnimalaiyaan, and H. Et-chen, A Mouse Model of Carcinoid Syndrome and Heart Disease, Journal of Surgical Research, vol.126, issue.1, pp.102-105, 2005.
DOI : 10.1016/j.jss.2005.01.003

K. Nakamura, Y. Sugawara, K. Sawabe, A. Ohashi, H. Tsurui et al., Late Developmental Stage-Specific Role of Tryptophan Hydroxylase 1 in Brain Serotonin Levels, Journal of Neuroscience, vol.26, issue.2, pp.530-534, 2006.
DOI : 10.1523/JNEUROSCI.1835-05.2006

C. G. Nebigil, D. S. Choi, A. Dierich, P. Hickel, L. Meur et al., Serotonin 2B receptor is required for heart development, Proceedings of the National Academy of Sciences of the United States of America, pp.9508-9513, 2000.
DOI : 10.1073/pnas.97.17.9508

C. G. Nebigil, N. Etienne, B. Schaerlinger, P. Hickel, J. M. Launay et al., Developmentally regulated serotonin 5-HT2B receptors, International Journal of Developmental Neuroscience, vol.19, issue.4, pp.365-372, 2001.
DOI : 10.1016/S0736-5748(01)00022-3

C. G. Nebigil, P. Hickel, N. Messaddeq, J. L. Vonesch, M. P. Douchet et al., Ablation of Serotonin 5-HT2B Receptors in Mice Leads to Abnormal Cardiac Structure and Function, Circulation, vol.103, issue.24, pp.2973-2979, 2001.
DOI : 10.1161/01.CIR.103.24.2973

C. G. Nebigil, F. Jaffre, N. Messaddeq, P. Hickel, L. Monassier et al., Overexpression of the Serotonin 5-HT2B Receptor in Heart Leads to Abnormal Mitochondrial Function and Cardiac Hypertrophy, Circulation, vol.107, issue.25, pp.3223-3229, 2003.
DOI : 10.1161/01.CIR.0000074224.57016.01

C. G. Nebigil and L. Et-maroteaux, Functional Consequence of Serotonin/5-HT2B Receptor Signaling in Heart: Role of Mitochondria in Transition Between Hypertrophy and Heart Failure?, Circulation, vol.108, issue.7, pp.902-908, 2003.
DOI : 10.1161/01.CIR.0000081520.25714.D9

W. S. Neckameyer and K. Et-white, A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila, The Journal of biological chemistry, vol.267, pp.4199-4206, 1992.

G. M. Nemecek, S. R. Coughlin, D. A. Handley, and M. A. Et-moskowitz, Stimulation of aortic smooth muscle cell mitogenesis by serotonin., Proceedings of the National Academy of Sciences, vol.83, issue.3, pp.674-678, 1986.
DOI : 10.1073/pnas.83.3.674

W. Ni and S. W. Et-watts, 5-HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT), Clinical and Experimental Pharmacology and Physiology, vol.285, issue.7, pp.575-583, 2006.
DOI : 10.2174/1389200033489433

A. Nicotra, F. Pierucci, H. Parvez, and O. Et-senatori, Monoamine Oxidase Expression During Development and Aging, NeuroToxicology, vol.25, issue.1-2, pp.155-165, 2004.
DOI : 10.1016/S0161-813X(03)00095-0

R. J. Noveck and J. W. Et-fisher, Erythropoietic Effects of 5-Hydroxytryptamine, Experimental Biology and Medicine, vol.138, issue.1, pp.103-107, 1971.
DOI : 10.3181/00379727-138-35840

O. 'kane, R. L. Et-hawkins, and R. A. , -dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier, American Journal of Physiology - Endocrinology And Metabolism, vol.285, issue.6, pp.1167-1173, 2003.
DOI : 10.1152/ajpendo.00193.2003

URL : https://hal.archives-ouvertes.fr/hal-00758186

J. Oliveras and M. Et-besson, Serotonin, stimulation-produced analgesia and spinal mechanisms of antinociception, 1992.

R. Ortiz-alvarado, O. Guzman-quevedo, R. Mercado-camargo, T. Haertle, C. Vignes et al., Expression of tryptophan hydroxylase in developing mouse taste papillae, FEBS Letters, vol.25, issue.22, pp.5371-5376, 2006.
DOI : 10.1016/j.febslet.2006.08.078

R. Pakala, J. T. Willerson, and C. R. Et-benedict, Mitogenic effect of serotonin on vascular endothelial cells, Circulation, vol.90, issue.4, pp.1919-1926, 1994.
DOI : 10.1161/01.CIR.90.4.1919

V. J. Parks, A. G. Sandison, S. L. Skinner, and R. F. Et-whelan, The stimulation of respiration by 5-hydroxytryptamine in man, The Journal of Physiology, vol.151, issue.2, pp.342-351, 1960.
DOI : 10.1113/jphysiol.1960.sp006442

S. R. Patel, J. H. Hartwig, J. E. Et-italiano, and . Jr, The biogenesis of platelets from megakaryocyte proplatelets, Journal of Clinical Investigation, vol.115, issue.12, pp.3348-3354, 2005.
DOI : 10.1172/JCI26891

S. J. Peroutka and S. H. Et-snyder, Multiple serotonin receptors: differential binding of [3H]5- hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol, Molecular pharmacology, vol.16, pp.687-699, 1979.

H. Plein and M. Et-berk, The platelet as a peripheral marker in psychiatric illness, Human Psychopharmacology: Clinical and Experimental, vol.27, issue.3, pp.229-236, 2001.
DOI : 10.1002/hup.251

O. Pucilowski and W. Et-kostowski, Aggressive behaviour and the central serotonergic systems, Behavioural Brain Research, vol.9, issue.1, pp.33-48, 1983.
DOI : 10.1016/0166-4328(83)90012-8

E. Pukhal-'skaya and S. Et-golubkova, Proliferation reaction of the bone marrow of rats to administration of serotonin. Chemical Abstracts 66, 1967.

E. Qvigstad, T. Brattelid, I. Sjaastad, K. W. Andressen, K. A. Krobert et al., Appearance of a ventricular 5-HT receptor-mediated inotropic response to serotonin in heart failure, Cardiovascular Research, vol.65, issue.4, pp.869-878, 2005.
DOI : 10.1016/j.cardiores.2004.11.017

E. Qvigstad, I. Sjaastad, T. Brattelid, C. Nunn, F. Swift et al., Dual Serotonergic Regulation of Ventricular Contractile Force Through 5-HT2A and 5-HT4 Receptors Induced in the Acute Failing Heart, Circulation Research, vol.97, issue.3, pp.268-276, 2005.
DOI : 10.1161/01.RES.0000176970.22603.8d

A. G. Ramage, Central cardiovascular regulation and 5-hydroxytryptamine receptors, Brain Research Bulletin, vol.56, issue.5, pp.425-439, 2001.
DOI : 10.1016/S0361-9230(01)00612-8

H. P. Rang, M. M. Dale, J. M. Ritter, and P. K. Et-moore, Other peripheral mediators: 5-hydroxytryptamine and purines, 2003.
DOI : 10.1016/B978-0-443-06911-6.50017-7

M. M. Rapport, Serum vasoconstrictor serotonin. V. The presence of creatinine in the complex: A proposed structure of the vasoconstrictor principle, The Journal of biological chemistry, vol.180, pp.961-969, 1949.

M. M. Rapport, A. A. Green, and I. H. Et-page, Partial purification of the vasoconstrictor in beef serum, The Journal of biological chemistry, vol.174, pp.735-741, 1948.

R. Green and A. , Neuropharmacology of 5-hydroxytryptamine, British Journal of Pharmacology, vol.14, issue.S1, pp.145-152, 2006.
DOI : 10.1038/sj.bjp.0706427

R. G. Robinson and M. D. Et-gershon, Synthesis and uptake of 5-hydroxytryptamine by the myenteric plexus of the guinea-pig ileum. A histochemical study, The Journal of pharmacology and experimental therapeutics, vol.178, pp.311-324, 1971.

D. K. Rohrer, K. H. Desai, J. R. Jasper, M. E. Stevens, D. P. Regula et al., Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects., Proceedings of the National Academy of Sciences of the United States of America 93, pp.7375-7380, 1996.
DOI : 10.1073/pnas.93.14.7375

R. B. Rothman and M. H. Et-baumann, Serotonin releasing agents, Pharmacology Biochemistry and Behavior, vol.71, issue.4, pp.825-836, 2002.
DOI : 10.1016/S0091-3057(01)00669-4

B. Rozec and C. Et-gauthier, ??3-Adrenoceptors in the cardiovascular system: Putative roles in human pathologies, Pharmacology & Therapeutics, vol.111, issue.3, pp.652-673, 2006.
DOI : 10.1016/j.pharmthera.2005.12.002

G. Rudnick and J. Et-clark, From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1144, issue.3, pp.249-263, 1993.
DOI : 10.1016/0005-2728(93)90109-S

V. P. Sah, M. Hoshijima, K. R. Chien, and J. H. Et-brown, Rho Is Required for G??q and ??1-Adrenergic Receptor Signaling in Cardiomyocytes: DISSOCIATION OF Ras AND Rho PATHWAYS, Journal of Biological Chemistry, vol.271, issue.49, pp.31185-31190, 1996.
DOI : 10.1074/jbc.271.49.31185

S. A. Sakowski, T. J. Geddes, D. M. Thomas, E. Levi, J. S. Hatfield et al., Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies, Brain Research, vol.1085, issue.1, pp.11-18, 2006.
DOI : 10.1016/j.brainres.2006.02.047

K. Salim, T. Fenton, J. Bacha, H. Urien-rodriguez, T. Bonnert et al., Oligomerization of G-protein-coupled Receptors Shown by Selective Co-immunoprecipitation, Journal of Biological Chemistry, vol.277, issue.18, pp.15482-15485, 2002.
DOI : 10.1074/jbc.M201539200

L. Sanders and A. J. Et-kaumann, A 5-HT4-like receptor in human left atrium. Naunyn- Schmiedeberg's archives of pharmacology 345, pp.382-386, 1992.

Y. Sari and F. C. Et-zhou, Serotonin and its transporter on proliferation of fetal heart cells, International Journal of Developmental Neuroscience, vol.21, issue.8, pp.417-424, 2003.
DOI : 10.1016/j.ijdevneu.2003.10.002

E. M. Sellers, G. A. Higgins, and M. B. Et-sobell, 5-HT and alcohol abuse, Trends in Pharmacological Sciences, vol.13, pp.69-75, 1992.
DOI : 10.1016/0165-6147(92)90026-3

V. L. Serebruany, Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? The American journal of medicine 119, pp.113-116, 2006.

H. S. Sharma, J. Westman, J. C. Navarro, P. K. Dey, and F. Et-nyberg, Probable involvement of serotonin in the increased permeability of the blood???brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat, Behavioural Brain Research, vol.72, issue.1-2, pp.189-196, 1995.
DOI : 10.1016/0166-4328(96)00170-2

D. L. Shuey, T. W. Sadler, H. Tamir, and J. M. Et-lauder, Serotonin and morphogenesis. Transient expression of serotonin uptake and binding protein during craniofacial morphogenesis in the mouse, Anatomy and embryology, vol.187, pp.75-85, 1993.
DOI : 10.1007/bf00208198

B. R. Sitaram and G. J. Et-lees, DIURNAL RHYTHM AND TURNOVER OF TRYPTOPHAN HYDROXYLASE IN THE PINEAL GLAND OF THE RAT, Journal of Neurochemistry, vol.18, issue.4, pp.1021-1026, 1978.
DOI : 10.1016/0003-2697(71)90291-0

J. M. Sneddon, Blood platelets as a model for monoamine-containing neurones, Progress in Neurobiology, vol.1, pp.151-198, 1973.
DOI : 10.1016/0301-0082(73)90019-1

S. M. Stahl, The Human Platelet, Archives of General Psychiatry, vol.34, issue.5, pp.509-516, 1977.
DOI : 10.1001/archpsyc.1977.01770170019001

S. M. Stahl and H. Y. Et-meltzer, A kinetic and pharmacologic analysis of 5-hydroxytryptamine transport by human platelets and platelet storage granules: comparison with central serotonergic neurons, The Journal of pharmacology and experimental therapeutics, vol.205, pp.118-132, 1978.

J. K. Staley, R. T. Malison, and R. B. Et-innis, Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression, Biological Psychiatry, vol.44, issue.7, pp.534-549, 1998.
DOI : 10.1016/S0006-3223(98)00185-1

H. W. Steinbusch and R. Et-nieuwenhuys, The raphe nuclei of the rat brainstem: a cytoarchitectonic and immunohistochemical study, 1983.

J. Y. Sze, M. Victor, C. Loer, Y. Shi, and G. Et-ruvkun, Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant, Nature, vol.2, issue.6769, pp.560-564, 2000.
DOI : 10.1038/35000609

N. J. Talley, Serotoninergic neuroenteric modulators, The Lancet, vol.358, issue.9298, pp.2061-2068, 2001.
DOI : 10.1016/S0140-6736(01)07103-3

G. Tavernier, G. Toumaniantz, M. Erfanian, M. F. Heymann, K. Laurent et al., ?-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human ?-adrenergic receptor, Cardiovascular Research, vol.59, issue.2, pp.288-296, 2003.
DOI : 10.1016/S0008-6363(03)00359-6

H. Teraoka, C. Russell, J. Regan, A. Chandrasekhar, M. L. Concha et al., Hedgehog and Fgf signaling pathways regulate the development oftphR-expressing serotonergic raphe neurons in zebrafish embryos, Journal of Neurobiology, vol.93, issue.3, pp.275-288, 2004.
DOI : 10.1002/neu.20023

E. Thevenot, Mutagenèse conditionnelle dans le système sérotoninergique central de la souris par transfert viral de la recombinase cre, p.125, 2003.

E. Thevenot, F. Cote, P. Colin, Y. He, H. Leblois et al., Targeting conditional gene modification into the serotonin neurons of the dorsal raphe nucleus by viral delivery of the Cre recombinase, Molecular and Cellular Neuroscience, vol.24, issue.1, pp.139-147, 2003.
DOI : 10.1016/S1044-7431(03)00131-3

S. Tiwari, J. E. Italiano, . Jr, D. C. Barral, E. H. Mules et al., A role for Rab27b in NF-E2-dependent pathways of platelet formation, Blood, vol.102, issue.12, pp.3970-3979, 2003.
DOI : 10.1182/blood-2003-03-0977

G. J. Tortora and S. R. Et-grabowski, Principles of Anatomy and Physiology, 1994.

J. P. Tranzer, M. Da-prada, and A. Et-pletscher, STORAGE OF 5-HYDROXYTRYPTAMINE IN MEGAKARYOCYTES, The Journal of Cell Biology, vol.52, issue.1, pp.191-197, 1972.
DOI : 10.1083/jcb.52.1.191

E. H. Turner, J. M. Loftis, and A. D. Et-blackwell, Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan, Pharmacology & Therapeutics, vol.109, issue.3, pp.325-338, 2006.
DOI : 10.1016/j.pharmthera.2005.06.004

B. M. Twarog, Responses of a molluscan smooth muscle to acetylcholine and 5-hydroxytryptamine, Journal of Cellular and Comparative Physiology, vol.165, issue.1, pp.141-163, 1954.
DOI : 10.1002/jcp.1030440112

B. M. Twarog and I. H. Et-page, Serotonin content of some mammalian tissues and urine and a method for its determination, The American journal of physiology, vol.175, pp.157-161, 1953.

C. Ullmer, K. Schmuck, H. O. Kalkman, and H. Et-lubbert, Expression of serotonin receptor mRNAs in blood vessels, FEBS Letters, vol.372, issue.3, pp.215-221, 1995.
DOI : 10.1016/0014-5793(95)00828-W

A. Van-den-bogaert, D. Zutter, S. Heyrman, L. Mendlewicz, J. Adolfsson et al., Response to Zhang et al. (2005) Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression. Neuron 45, 11???16, Neuron, vol.48, issue.5, pp.11-16, 2005.
DOI : 10.1016/j.neuron.2005.11.017

T. Vitalis, C. Fouquet, C. Alvarez, I. Seif, D. Price et al., Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse, The Journal of Comparative Neurology, vol.71, issue.4, pp.331-347, 2002.
DOI : 10.1002/cne.10093

V. Borell, E. Langbein, J. Despres, G. Hansen, S. Leterrier et al., Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals ??? A review, Physiology & Behavior, vol.92, issue.3, 2007.
DOI : 10.1016/j.physbeh.2007.01.007

B. Von-mentzer, Y. Murata, I. Ahlstedt, E. Lindstrom, and V. Et-martinez, Functional CRF receptors in BON cells stimulate serotonin release, Biochemical Pharmacology, vol.73, issue.6, pp.805-813, 2007.
DOI : 10.1016/j.bcp.2006.11.019

J. A. Wallace and J. M. Et-lauder, Development of the serotonergic system in the rat embryo: An immunocytochemical study, Brain Research Bulletin, vol.10, issue.4, pp.459-479, 1983.
DOI : 10.1016/0361-9230(83)90144-2

D. J. Walther and M. Et-bader, A unique central tryptophan hydroxylase isoform, Biochemical Pharmacology, vol.66, issue.9, pp.1673-1680, 2003.
DOI : 10.1016/S0006-2952(03)00556-2

D. J. Walther, J. U. Peter, S. Bashammakh, H. Hortnagl, M. Voits et al., Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform, Science, vol.299, issue.5603, p.76, 2003.
DOI : 10.1126/science.1078197

D. J. Walther, J. U. Peter, S. Winter, M. Holtje, N. Paulmann et al., Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet ??-Granule Release, Cell, vol.115, issue.7, pp.851-862, 2003.
DOI : 10.1016/S0092-8674(03)01014-6

Y. Wang and A. G. Et-ramage, receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats, The Journal of Physiology, vol.186, issue.3, pp.753-767, 2001.
DOI : 10.1111/j.1469-7793.2001.00753.x

S. W. Watts, 5-HT in systemic hypertension: foe, friend or fantasy?, Clinical Science, vol.108, issue.5, pp.399-412, 2005.
DOI : 10.1042/CS20040364

S. W. Watts, M. Baez, and R. C. Et-webb, The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats, The Journal of pharmacology and experimental therapeutics, vol.277, pp.1103-1113, 1996.

S. W. Watts and G. D. Et-fink, 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCAsalt-hypertensive rats, The American journal of physiology, vol.276, pp.944-952, 1999.

S. W. Watts and R. C. Et-webb, Mechanism of ergonovine-induced contraction in the mesenteric artery from deoxycorticosterone acetate-salt hypertensive rat, The Journal of pharmacology and experimental therapeutics, vol.269, pp.617-625, 1994.

C. Weidenfeller, C. N. Svendsen, and E. V. Et-shusta, Differentiating embryonic neural progenitor cells induce blood?brain barrier properties, Journal of Neurochemistry, vol.63, issue.2, 2007.
DOI : 10.1002/(SICI)1096-9861(19971103)387:4<537::AID-CNE5>3.0.CO;2-3

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657050

N. J. Weissman, J. F. Tighe, . Jr, J. S. Gottdiener, and J. T. Et-gwynne, An Assessment of Heart-Valve Abnormalities in Obese Patients Taking Dexfenfluramine, Sustained-Release Dexfenfluramine, or Placebo, New England Journal of Medicine, vol.339, issue.11, pp.725-732, 1998.
DOI : 10.1056/NEJM199809103391103

P. M. Whitaker-azmitia, The Discovery of Serotonin and its Role in Neuroscience, Neuropsychopharmacology, vol.21, issue.2, pp.2-8, 1999.
DOI : 10.1016/S0893-133X(99)00031-7

L. Wiklund, L. Leger, and M. Et-persson, Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups, The Journal of Comparative Neurology, vol.191, issue.4, pp.613-647, 1981.
DOI : 10.1002/cne.902030405

D. W. Woolley and E. Shaw, A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS, Proceedings of the National Academy of Sciences, vol.40, issue.4, pp.228-231, 1954.
DOI : 10.1073/pnas.40.4.228

Z. Xie, S. P. Lee, B. F. O-'dowd, and S. R. Et-george, receptors form homodimers when expressed alone and heterodimers when co-expressed, FEBS Letters, vol.8, issue.1, pp.63-67, 1999.
DOI : 10.1016/S0014-5793(99)00918-7

M. Yamada and H. Et-yasuhara, Clinical Pharmacology of MAO Inhibitors: Safety and Future, NeuroToxicology, vol.25, issue.1-2, pp.215-221, 2004.
DOI : 10.1016/S0161-813X(03)00097-4

M. Yang, A. Srikiatkhachorn, M. Anthony, C. N. Chesterman, and B. H. Et-chong, Serotonin uptake, storage and metabolism in megakaryoblasts, International journal of hematology, vol.63, pp.137-142, 1996.

M. Yang, A. Srikiatkhachorn, M. Anthony, and B. H. Et-chong, Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor, Blood Coagulation & Fibrinolysis, vol.7, issue.2, pp.127-133, 1996.
DOI : 10.1097/00001721-199603000-00004

M. S. Yavarone, D. L. Shuey, H. Tamir, T. W. Sadler, and J. M. Et-lauder, Serotonin and cardiac morphogenesis in the mouse embryo, Teratology, vol.3, issue.6, pp.573-584, 1993.
DOI : 10.1002/tera.1420470609

M. B. Youdim, Platelet monoamine oxidase B: Use and misuse, Experientia, vol.48, issue.2, pp.137-141, 1988.
DOI : 10.1007/BF01952197

M. B. Youdim, D. Edmondson, and K. F. Et-tipton, The therapeutic potential of monoamine oxidase inhibitors, Nature Reviews Neuroscience, vol.47, issue.4, pp.295-309, 2006.
DOI : 10.1038/nrn1883

S. Yusuf, N. Al-saady, and A. J. Et-camm, 5-Hydroxytryptamine and Atrial Fibrillation:, Journal of Cardiovascular Electrophysiology, vol.2, issue.2, pp.209-214, 2003.
DOI : 10.1046/j.1540-8167.2003.02381.x

X. Zhang, J. M. Beaulieu, R. R. Gainetdinov, and M. G. Et-caron, Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2, Cellular and Molecular Life Sciences, vol.22, issue.1, pp.6-11, 2006.
DOI : 10.1007/s00018-005-5417-4

X. Zhang, J. M. Beaulieu, T. D. Sotnikova, R. R. Gainetdinov, and M. G. Et-caron, Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis, Science, vol.305, issue.5681, p.217, 2004.
DOI : 10.1126/science.1097540

X. Zhang, R. R. Gainetdinov, J. M. Beaulieu, T. D. Sotnikova, L. H. Burch et al., Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression, Neuron, vol.45, issue.1, pp.11-16, 2005.
DOI : 10.1016/j.neuron.2004.12.014

Z. Q. Zhao, M. Scott, S. Chiechio, J. S. Wang, K. J. Renner et al., Lmx1b Is Required for Maintenance of Central Serotonergic Neurons and Mice Lacking Central Serotonergic System Exhibit Normal Locomotor Activity, Journal of Neuroscience, vol.26, issue.49, pp.12781-12788, 2006.
DOI : 10.1523/JNEUROSCI.4143-06.2006

Q. Y. Zhou, C. J. Quaife, and R. D. Et-palmiter, Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development, Nature, vol.374, issue.6523, pp.640-643, 1995.
DOI : 10.1038/374640a0

Z. Zhou, E. J. Peters, S. P. Hamilton, F. Mcmahon, C. Thomas et al., Response to Zhang et al., (2005) Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression. Neuron 45, 11???16, Neuron, vol.48, issue.5, pp.11-16, 2005.
DOI : 10.1016/j.neuron.2005.11.018

P. Zill, A. Buttner, W. Eisenmenger, H. J. Moller, M. Ackenheil et al., Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: A post-mortem study, Journal of Psychiatric Research, vol.41, issue.1-2, pp.168-173, 2007.
DOI : 10.1016/j.jpsychires.2005.05.004