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Theses

Developpement d'outils bioinformatiques et statistiques pour l'analyse du transcriptome hepatique humain par puces a ADN : application a la reponse inflammatoire aigue systemique.

Abstract : The inflammation acute phase is a transitional period that follows the trauma, predominantly coordinated by mediators such as cytokines. The latter mainly targets the liver which then regulates among others APP and APRIPS production.
This work initially shows the creation of a microarray platform dedicated to
human hepatic transcriptome analysis and founded on the one hand on the development of the microarray itself by indicating cDNA probes which define it, on the other hand on the creation of a standardized database and also by the writing of statistical analysis software.
It shows finally how this platform allowed to highlight on the one hand a correlation between both 134 transcripts and inflammation degree and on the other hand a list of genes clustered in 12 functional groups undergoing modifications of their transcription, their post-transcriptionnal stability and their translation during the inflammation acute phase.
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https://tel.archives-ouvertes.fr/tel-00182773
Contributor : Gregory Lefebvre <>
Submitted on : Sunday, October 28, 2007 - 12:44:26 AM
Last modification on : Tuesday, February 5, 2019 - 11:44:18 AM
Long-term archiving on: : Monday, April 12, 2010 - 12:52:47 AM

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  • HAL Id : tel-00182773, version 1

Citation

Gregory Lefebvre. Developpement d'outils bioinformatiques et statistiques pour l'analyse du transcriptome hepatique humain par puces a ADN : application a la reponse inflammatoire aigue systemique.. Sciences du Vivant [q-bio]. Université de Rouen, 2006. Français. ⟨tel-00182773⟩

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