Bioenergetics and the formation of mitochondrial reactive oxygen species, Trends in Pharmacological Sciences, vol.27, issue.12, pp.639-645, 2006. ,
DOI : 10.1016/j.tips.2006.10.005
Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-??B in Leukocyte Recruitment, The Journal of Immunology, vol.167, issue.3, pp.1592-1600, 2001. ,
DOI : 10.4049/jimmunol.167.3.1592
Bone Marrow Transplantation Reveals the in Vivo Expression of the Mitochondrial Uncoupling Protein 2 in Immune and Nonimmune Cells during Inflammation, Journal of Biological Chemistry, vol.278, issue.43, pp.42307-42319, 2003. ,
DOI : 10.1074/jbc.M306951200
Uncoupling Protein-2 Is Critical for Nigral Dopamine Cell Survival in a Mouse Model of Parkinson's Disease, Journal of Neuroscience, vol.25, issue.1, pp.184-91, 2005. ,
DOI : 10.1523/JNEUROSCI.4269-04.2005
Mitochondrial metabolism of reactive oxygen species, Biochemistry (Moscow), vol.1058, issue.13, pp.200-214, 2005. ,
DOI : 10.1007/s10541-005-0102-7
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production, Nat. Genet, vol.26, pp.435-444, 2000. ,
Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-??B, The Journal of Immunology, vol.172, issue.4, pp.2522-2531, 2004. ,
DOI : 10.4049/jimmunol.172.4.2522
Type 1 diabetes: new perspectives on disease pathogenesis and treatment, The Lancet, vol.358, issue.9277, pp.221-230, 2001. ,
DOI : 10.1016/S0140-6736(01)05415-0
Association of CTLA-4 Gene A-G Polymorphism (IDDM12 Locus) With Acute-Onset and Insulin-Depleted IDDM as Well as Autoimmune Thyroid Disease (Graves' Disease and Hashimoto's Thyroiditis) in the Japanese Population, Diabetes, vol.47, issue.1, pp.128-137, 1998. ,
DOI : 10.2337/diab.47.1.128
Persistent Nuclear Factor-??B Activation in Ucp2-/- Mice Leads to Enhanced Nitric Oxide and Inflammatory Cytokine Production, Journal of Biological Chemistry, vol.280, issue.19, pp.19062-19071, 2005. ,
DOI : 10.1074/jbc.M500566200
The extra respiration of phagocytosis, Am. J. Physiol, vol.103, pp.235-236, 1933. ,
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology, Physiological Reviews, vol.87, issue.1, pp.245-313, 2007. ,
DOI : 10.1152/physrev.00044.2005
HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes, Annual Review of Genetics, vol.30, issue.1, pp.343-70, 1996. ,
DOI : 10.1146/annurev.genet.30.1.343
Protective Role of Uncoupling Protein 2 in Atherosclerosis, Circulation, vol.107, issue.3, pp.388-90, 2003. ,
DOI : 10.1161/01.CIR.0000051722.66074.60
Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation, Immunology, vol.100, issue.4, pp.513-535, 2003. ,
DOI : 10.1006/niox.2001.0415
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782926
On regulation of phagosome maturation and antigen presentation, Nature Immunology, vol.173, issue.10, pp.1029-1064, 2006. ,
DOI : 10.1084/jem.20052433
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice, Journal of Clinical Investigation, vol.103, issue.10, pp.1431-1437, 1999. ,
DOI : 10.1172/JCI5241
Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation, Cell, vol.115, issue.1, pp.71-82, 2003. ,
DOI : 10.1016/S0092-8674(03)00755-4
Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein., Proceedings of the National Academy of Sciences, vol.82, issue.2, pp.445-453, 1985. ,
DOI : 10.1073/pnas.82.2.445
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ?? Cells, PLoS Biology, vol.146, issue.2, p.31, 2006. ,
DOI : 10.1371/journal.pbio.0040031.sg001
Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide, Blood, vol.99, issue.9, pp.3427-3458, 2002. ,
DOI : 10.1182/blood.V99.9.3427
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins, Free Radical Biology and Medicine, vol.37, issue.6, pp.755-67, 2004. ,
DOI : 10.1016/j.freeradbiomed.2004.05.034
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3, Cell Metabolism, vol.2, issue.2, pp.85-93, 2005. ,
DOI : 10.1016/j.cmet.2005.06.002
ISLET CELL TUMORS OF THE PANCREAS, Surgical Clinics of North America, vol.81, issue.3, pp.527-569, 2001. ,
DOI : 10.1016/S0039-6109(05)70141-9
Differential Effects of Hyperlipidemia on Insulin Secretion in Islets of Langerhans From Hyperglycemic Versus Normoglycemic Rats, Diabetes, vol.51, issue.3, pp.662-670, 2002. ,
DOI : 10.2337/diabetes.51.3.662
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation, Science, vol.267, issue.5203, pp.1485-1493, 1995. ,
DOI : 10.1126/science.7878466
The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is further stimulated by mersalyl, J Biol Chem, vol.269, pp.27329-27365, 1994. ,
Stimulation of glycolysis as an activation signal in rat peritoneal macrophages. Effect of glucocorticoids on this process, Biochemical Journal, vol.282, issue.1, pp.299-303, 1992. ,
DOI : 10.1042/bj2820299
Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK, Antioxidants & Redox Signaling, vol.7, issue.5-6, pp.726-766, 2005. ,
DOI : 10.1089/ars.2005.7.726
Brown Adipose Tissue: Function and Physiological Significance, Physiological Reviews, vol.84, issue.1, pp.277-359, 2004. ,
DOI : 10.1152/physrev.00015.2003
IRAK: A Kinase Associated with the Interleukin-1 Receptor, Science, vol.271, issue.5252, pp.1128-1159, 1996. ,
DOI : 10.1126/science.271.5252.1128
TRAF6 is a signal transducer for interleukin-1, Nature, vol.383, issue.6599, pp.443-449, 1996. ,
DOI : 10.1038/383443a0
Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens, Diabetes, vol.46, issue.12, pp.1975-82, 1997. ,
DOI : 10.2337/diabetes.46.12.1975
Increased Uncoupling Protein-2 Levels in ??-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion: Mechanism of Action, Diabetes, vol.50, issue.6, pp.1302-1312, 2001. ,
DOI : 10.2337/diabetes.50.6.1302
Hydroperoxide metabolism in mammalian organs, Physiol. Rev, vol.59, pp.527-605, 1979. ,
c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation, Journal of Biological Chemistry, vol.276, issue.19, pp.16045-50, 2001. ,
DOI : 10.1074/jbc.M011766200
Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages, The Journal of Immunology, vol.169, issue.11, pp.6408-6424, 2002. ,
DOI : 10.4049/jimmunol.169.11.6408
Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III, Journal of Biological Chemistry, vol.278, issue.38, pp.36027-36058, 2003. ,
DOI : 10.1074/jbc.M304854200
Ubiquitin signalling in the NF-kappaB pathway, Nat. Cell. Biol, pp.758-65, 2005. ,
MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity, Diabetes, vol.54, issue.5, pp.1437-1483, 2005. ,
DOI : 10.2337/diabetes.54.5.1437
Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production, Diabetes, vol.56, issue.4, pp.1042-50, 2007. ,
DOI : 10.2337/db06-1300
Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors, Diabetes, vol.42, issue.1, pp.44-55, 1993. ,
DOI : 10.2337/diab.42.1.44
Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain, NeuroReport, vol.14, issue.16, pp.2015-2022, 2003. ,
DOI : 10.1097/00001756-200311140-00002
Cold-induced enhancement of avian uncoupling protein expression, heat production, and triiodothyronine concentrations in broiler chicks, General and Comparative Endocrinology, vol.130, issue.1, pp.70-77, 2003. ,
DOI : 10.1016/S0016-6480(02)00571-3
Uncoupling protein???2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity, Journal of Neurochemistry, vol.281, issue.2, pp.493-501, 2005. ,
DOI : 10.1111/j.1471-4159.2005.03052.x
Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span, Science, vol.314, issue.5800, pp.825-833, 2006. ,
DOI : 10.1126/science.1132191
A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2, Cell Metabolism, vol.5, issue.1, pp.21-33, 2007. ,
DOI : 10.1016/j.cmet.2006.12.002
-dependent ???malic??? enzyme, Biochemical Journal, vol.310, issue.2, pp.709-723, 1995. ,
DOI : 10.1042/bj3100709
URL : https://hal.archives-ouvertes.fr/in2p3-00025569
No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria, Journal of Biological Chemistry, vol.277, issue.29, 2002. ,
DOI : 10.1074/jbc.M202535200
The -866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes, Diabetes, vol.53, issue.7, pp.1905-1915, 2004. ,
DOI : 10.2337/diabetes.53.7.1905
Non-genetic risk determinants of type 1 diabetes, Diabete Metab, vol.20, pp.251-258, 1994. ,
Inflammation: the link between insulin resistance, obesity and diabetes, Trends in Immunology, vol.25, issue.1, pp.4-7, 2004. ,
DOI : 10.1016/j.it.2003.10.013
1. Signal transduction by the c-Jun N-terminal kinase, Biochem. Soc. Symp, vol.64, pp.1-12, 1999. ,
DOI : 10.1515/9781400865048.1
URL : https://hal.archives-ouvertes.fr/in2p3-00166111
Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels, Journal of Neurochemistry, vol.89, issue.5, pp.1283-92, 2004. ,
DOI : 10.1111/j.1471-4159.2004.02432.x
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action, The FASEB Journal, vol.21, issue.4, pp.1153-63, 2007. ,
DOI : 10.1096/fj.06-7148com
Neutrophils, dendritic cells and Toxoplasma, International Journal for Parasitology, vol.34, issue.3, pp.411-432, 2004. ,
DOI : 10.1016/j.ijpara.2003.11.001
Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection, Immunological Reviews, vol.10, issue.1, pp.191-205, 2004. ,
DOI : 10.1083/jcb.127.4.947
Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning, Endocrinology, vol.144, issue.11, pp.5014-5035, 2003. ,
DOI : 10.1210/en.2003-0667
Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts, Oncogene, vol.13, pp.925-956, 1996. ,
A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis, Diabetologia, vol.44, issue.12, pp.2115-2148, 2001. ,
DOI : 10.1007/s001250100021
Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes, Diabetes, vol.50, issue.Supplement 1, pp.64-73, 2001. ,
DOI : 10.2337/diabetes.50.2007.S64
Conditional and specific NF-??B blockade protects pancreatic beta cells from diabetogenic agents, Proceedings of the National Academy of Sciences, vol.103, issue.13, pp.5072-5079, 2006. ,
DOI : 10.1073/pnas.0508166103
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458796
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans, Nature Genetics, vol.28, issue.2, pp.178-83, 2001. ,
DOI : 10.1038/88911
Molecular mechanisms of endotoxin tolerance, Journal of Endotoxin Research, vol.10, issue.2, pp.71-84, 2004. ,
DOI : 10.1179/096805104225003997
Oxygen radicals and signaling, Current Opinion in Cell Biology, vol.10, issue.2, pp.248-53, 1998. ,
DOI : 10.1016/S0955-0674(98)80147-6
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia, Nature Genetics, vol.281, issue.3, pp.269-72, 1997. ,
DOI : 10.1056/NEJM199508103330605
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes, Diabetes, vol.48, issue.4, pp.706-719, 1999. ,
DOI : 10.2337/diabetes.48.4.706
Redox Regulation of NF-kappa B Activation, Free Radical Biology and Medicine, vol.22, issue.6, pp.1115-1141, 1997. ,
DOI : 10.1016/S0891-5849(96)00501-1
Structure and regulation of MAPK phosphatases, Cellular Signalling, vol.16, issue.7, pp.769-79, 2004. ,
DOI : 10.1016/j.cellsig.2003.12.008
Redox signaling in macrophages, Molecular Aspects of Medicine, vol.22, issue.4-5, pp.189-216, 2001. ,
DOI : 10.1016/S0098-2997(01)00010-3
The biology of oxygen radicals, Science, vol.201, issue.4359, pp.875-80, 1978. ,
DOI : 10.1126/science.210504
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, vol.265, issue.5789, pp.373-379, 1980. ,
DOI : 10.1038/288373a0
Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men, Diabetes, vol.55, issue.5, pp.1504-1515, 2006. ,
DOI : 10.2337/db05-1645
Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical, J. Biol. Chem, vol.267, pp.8757-63, 1992. ,
Aconitase: Sensitive target and measure of superoxide, Methods Enzymol, vol.349, pp.9-23, 2002. ,
DOI : 10.1016/S0076-6879(02)49317-2
The mechanism of proton transport mediated by mitochondrial uncoupling proteins, FEBS Letters, vol.4, issue.1-2, 1998. ,
DOI : 10.1016/S0014-5793(98)01246-0
NF-??B activation by reactive oxygen species: Fifteen years later, Biochemical Pharmacology, vol.72, issue.11, pp.1493-505, 2006. ,
DOI : 10.1016/j.bcp.2006.04.011
A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet, The FASEB Journal, vol.17, issue.12, pp.1585-91, 2003. ,
DOI : 10.1096/fj.03-0159hyp
Monocyte and macrophage heterogeneity, Nature Reviews Immunology, vol.33, issue.12, pp.953-64, 2005. ,
DOI : 10.1038/nri1733
In-vivo effects of lipopolysaccharide on lymphoid and non-lymphoid cells in the mouse spleen, Cell and Tissue Research, vol.234, issue.1, pp.201-209, 1983. ,
DOI : 10.1007/BF00217413
LPS induction of gene expression in human monocytes, Cellular Signalling, vol.13, issue.2, pp.85-94, 2001. ,
DOI : 10.1016/S0898-6568(00)00149-2
Hydrogen peroxide in the human body, FEBS Letters, vol.20, issue.1, pp.10-13, 2000. ,
DOI : 10.1016/S0014-5793(00)02197-9
Listeria monocytogenes: a multifaceted model, Nature Reviews Microbiology, vol.73, issue.6, pp.423-457, 2006. ,
DOI : 10.1038/nrmicro1413
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14, J. Biol. Chem, vol.268, pp.25009-25023, 1993. ,
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Science, vol.265, issue.5173, pp.808-819, 1994. ,
DOI : 10.1126/science.7914033
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages, Biochemical Journal, vol.242, issue.1, pp.103-110, 1987. ,
DOI : 10.1042/bj2420103
Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats, Diabetologia, vol.32, issue.2, pp.126-160, 1989. ,
DOI : 10.1007/BF00505185
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria, Biochemical Journal, vol.361, issue.1, pp.49-56, 2002. ,
DOI : 10.1042/bj3610049
The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock, Journal of Experimental Medicine, vol.93, issue.7, pp.1431-1440, 1997. ,
DOI : 10.1073/pnas.93.7.2774
Brown-Adipose-Tissue Mitochondria: Photoaffinity Labelling of the Regulatory Site of Energy Dissipation, European Journal of Biochemistry, vol.67, issue.2, pp.515-536, 1978. ,
DOI : 10.1016/0014-5793(77)80169-5
UV-induced free radicals in the skin detected by ESR spectroscopy and imaging using nitroxides. Free Radic, Biol. Med, vol.35, pp.59-67, 2003. ,
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558., Journal of Clinical Investigation, vol.87, issue.1, pp.352-358, 1991. ,
DOI : 10.1172/JCI114993
Chronic granulomatous disease, Current Opinion in Immunology, vol.15, issue.5, pp.578-84, 2003. ,
DOI : 10.1016/S0952-7915(03)00109-2
Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat, Diabetes, vol.55, issue.6, pp.1625-1658, 2006. ,
DOI : 10.2337/db05-1526
Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells, Diabetologia, vol.37, issue.Suppl 2, pp.22-31, 1994. ,
DOI : 10.1007/BF00428773
Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice, International Journal of Obesity, vol.27, issue.4, pp.433-475, 2003. ,
DOI : 10.1038/sj.ijo.0802257
Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression, Journal of Biological Chemistry, vol.277, issue.25, pp.22131-22140, 2002. ,
DOI : 10.1074/jbc.M111883200
Sensitization of IFN-?? Jak-STAT signaling during macrophage activation, Nature Immunology, vol.3, issue.9, pp.859-66, 2002. ,
DOI : 10.1038/ni828
Translation control of UCP2 synthesis by the upstream open reading frame, Cellular and Molecular Life Sciences, vol.63, issue.15, pp.1780-1789, 2006. ,
DOI : 10.1007/s00018-006-6129-0
URL : https://hal.archives-ouvertes.fr/hal-00136095
Glutamine stimulates translation of Uncoupling Protein 2 mRNA, Cell. Mol. Life Sci, 2007. ,
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study, The Lancet, vol.358, issue.9292, pp.1500-1503, 2001. ,
DOI : 10.1016/S0140-6736(01)06580-1
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro, Science, vol.240, issue.4852, pp.640-642, 1988. ,
DOI : 10.1126/science.2834821
Transport Function and Regulation of Mitochondrial Uncoupling Proteins 2 and 3, Journal of Biological Chemistry, vol.274, issue.37, pp.26003-26010, 1999. ,
DOI : 10.1074/jbc.274.37.26003
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice, Diabetes, vol.43, issue.5, pp.667-75, 1994. ,
DOI : 10.2337/diabetes.43.5.667
Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic, Biol. Med, vol.28, pp.1317-1344, 2000. ,
Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis, Physiological Genomics, vol.22, issue.2, pp.150-156, 2005. ,
DOI : 10.1152/physiolgenomics.00070.2005
New substrates and competitive inhibitors of the Cltranslocating pathway of the uncoupling protein of brown adipose tissue mitochondria, 1990. ,
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet, Diabetes, vol.51, issue.11, pp.3211-3220, 2002. ,
DOI : 10.2337/diabetes.51.11.3211
Free Fatty Acid-induced ??-Cell Defects Are Dependent on Uncoupling Protein 2 Expression, Journal of Biological Chemistry, vol.279, issue.49, pp.51049-56, 2004. ,
DOI : 10.1074/jbc.M409189200
Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice, Diabetes, vol.48, issue.1, pp.34-42, 1999. ,
DOI : 10.2337/diabetes.48.1.34
The Role of Macrophages in T Cell???mediated Autoimmune Diabetes in Nonobese Diabetic Mice, The Journal of Experimental Medicine, vol.71, issue.2, 1999. ,
DOI : 10.1016/S0092-8674(00)80178-6
Redox Regulation of Cellular Signalling, Cellular Signalling, vol.11, issue.1, pp.1-14, 1999. ,
DOI : 10.1016/S0898-6568(98)00037-0
Interleukin (IL)-1 Receptor???associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production, The Journal of Experimental Medicine, vol.158, issue.12, pp.2073-2082, 1998. ,
DOI : 10.1074/jbc.273.6.3285
Correlation Between Pancreatic Islet Uncoupling Protein-2 (UCP2) mRNA Concentration And Insulin Status in Rats, International Journal of Experimental Diabetes Research, vol.1, issue.3, pp.185-93, 2000. ,
DOI : 10.1155/EDR.2000.185
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes, Nature, vol.366, issue.6450, pp.69-72, 1993. ,
DOI : 10.1038/366069a0
Unresponsiveness of MyD88-Deficient Mice to Endotoxin, Immunity, vol.11, issue.1, pp.115-137, 1999. ,
DOI : 10.1016/S1074-7613(00)80086-2
TLR signaling, Cell Death and Differentiation, vol.175, issue.5, pp.816-841, 2006. ,
DOI : 10.1038/nature03124
The Drosophila membrane receptor Toll can function to promote cellular adhesion, EMBO J, vol.9, pp.4299-306, 1990. ,
Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages, Proc. Natl, 2002. ,
DOI : 10.1073/pnas.142206299
Impaired Pulmonary NF-??B Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice, Infection and Immunity, vol.69, issue.10, pp.5991-5997, 2001. ,
DOI : 10.1128/IAI.69.10.5991-5996.2001
Analysis of 22 immunomodulatory substances for efficacy in low-dose streptozotocin-induced diabetes, Diabetes Res, vol.6, pp.21-28, 1987. ,
Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset, Diabetes, vol.37, issue.1, pp.21-28, 1988. ,
DOI : 10.2337/diab.37.1.21
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling, Cell, vol.110, issue.2, pp.191-202, 2002. ,
DOI : 10.1016/S0092-8674(02)00827-9
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements, Immunity, vol.10, issue.3, pp.387-98, 1999. ,
DOI : 10.1016/S1074-7613(00)80038-2
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology, The EMBO Journal, vol.20, issue.14, pp.3760-70, 2001. ,
DOI : 10.1093/emboj/20.14.3760
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125555
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2, Proceedings of the National Academy of Sciences, vol.99, issue.1, pp.118-140, 2002. ,
DOI : 10.1073/pnas.012410699
A Functional Polymorphism in the Promoter of UCP2 Enhances Obesity Risk but Reduces Type 2 Diabetes Risk in Obese Middle-Aged Humans, Diabetes, vol.51, issue.11, pp.3331-3336, 2002. ,
DOI : 10.2337/diabetes.51.11.3331
T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation. Free Radic, Biol. Med, vol.35, pp.406-423, 2003. ,
A plant cold-induced uncoupling protein, Nature, vol.389, issue.6647, pp.135-141, 1997. ,
DOI : 10.1038/38156
DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response, The Journal of Immunology, vol.177, issue.11, pp.7497-504, 2006. ,
DOI : 10.4049/jimmunol.177.11.7497
Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model, Journal of Experimental Medicine, vol.181, issue.5, pp.1635-1677, 1995. ,
DOI : 10.1084/jem.181.5.1635
Interleukin-1??-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases, Journal of Biological Chemistry, vol.273, issue.24, pp.15294-300, 1998. ,
DOI : 10.1074/jbc.273.24.15294
The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity, Nat. Genet, vol.26, pp.444-450, 2000. ,
Metal-induced oxidative stress and signal transduction. Free Radic, Biol. Med, vol.37, pp.1921-1963, 2004. ,
DOI : 10.1016/j.freeradbiomed.2004.09.010
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase, Nature Genetics, vol.37, issue.4, pp.376-81, 1995. ,
DOI : 10.1016/0092-8674(92)90270-M
Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production, Biochemical and Biophysical Research Communications, vol.253, issue.2, pp.295-304, 1998. ,
DOI : 10.1006/bbrc.1998.9729
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation, Genes Dev, vol.14, pp.1729-1762, 2000. ,
Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus, Science, vol.193, issue.4251, pp.415-422, 1976. ,
DOI : 10.1126/science.180605
The interplay between Salmonella typhimurium and its macrophage host???what can it teach us about innate immunity?, Immunology Letters, vol.85, issue.2, pp.183-92, 2003. ,
DOI : 10.1016/S0165-2478(02)00227-4
MAPK phosphatases ??? regulating the immune response, Nature Reviews Immunology, vol.56, issue.1, pp.202-214, 2007. ,
DOI : 10.1038/nri2035
Increase in p53 protein half-life in mouse keratinocytes following UV-B irradiation, Carcinogenesis, vol.15, issue.6, pp.1089-92, 1994. ,
DOI : 10.1093/carcin/15.6.1089
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, pp.1015-1039, 1999. ,
DOI : 10.1101/gad.13.8.1015
Cytokine overexpression and constitutive NFkappaB in cancer, Cell Cycle, vol.3, pp.1114-1121, 2004. ,
Oxidative Stress Augments the Production of Matrix Metalloproteinase-1, Cyclooxygenase-2, and Prostaglandin E2 through Enhancement of NF-??B Activity in Lipopolysaccharide-Activated Human Primary Monocytes, The Journal of Immunology, vol.175, issue.8, pp.5423-5432, 2005. ,
DOI : 10.4049/jimmunol.175.8.5423
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways, Antioxidants & Redox Signaling, vol.8, issue.9-10, pp.1775-89, 2006. ,
DOI : 10.1089/ars.2006.8.1775
NITRIC OXIDE AND MACROPHAGE FUNCTION, Annual Review of Immunology, vol.15, issue.1, 1997. ,
DOI : 10.1146/annurev.immunol.15.1.323
Back to Central Tolerance, Immunity, vol.20, issue.5, pp.509-525, 2004. ,
DOI : 10.1016/S1074-7613(04)00111-6
URL : http://doi.org/10.1016/s1074-7613(04)00111-6
Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.282, issue.6, 2002. ,
DOI : 10.1152/ajplung.00453.2001
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways, Molecular Cell, vol.2, issue.2, pp.253-261, 1998. ,
DOI : 10.1016/S1097-2765(00)80136-7
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene, Human Immunology, vol.51, issue.1, pp.41-49, 1996. ,
DOI : 10.1016/S0198-8859(96)00206-6
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele, Nature Genetics, vol.27, issue.2, pp.218-239, 2000. ,
DOI : 10.1038/84872
Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry, J. Immunol, vol.159, pp.4452-4461, 1997. ,
Establishes a Moving Junction That Selectively Excludes Host Cell Plasma Membrane Proteins on the Basis of Their Membrane Anchoring, The Journal of Experimental Medicine, vol.5, issue.12, pp.1783-92, 1999. ,
DOI : 10.1073/pnas.94.24.12969
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose, Biochemical Journal, vol.393, issue.1, pp.431-440, 2006. ,
DOI : 10.1042/BJ20050494
URL : https://hal.archives-ouvertes.fr/hal-00136148
Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes, J. Leukoc. Biol, vol.66, pp.698-704, 1999. ,
IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling, Science, vol.278, issue.5343, pp.1612-1617, 1997. ,
DOI : 10.1126/science.278.5343.1612
Localized Reactive Oxygen and Nitrogen Intermediates Inhibit Escape of Listeria monocytogenes from Vacuoles in Activated Macrophages, The Journal of Immunology, vol.171, issue.10, pp.5447-53, 2003. ,
DOI : 10.4049/jimmunol.171.10.5447
REDOX REGULATION OF CELLULAR ACTIVATION, Annual Review of Immunology, vol.15, issue.1, 1997. ,
DOI : 10.1146/annurev.immunol.15.1.351
Brown adipose tissue mitochondria, Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, vol.549, issue.1, pp.1-29, 1979. ,
DOI : 10.1016/0304-4173(79)90016-8
Thermogenic mechanisms in brown fat, Physiol. Rev, vol.64, pp.1-64, 1984. ,
In-vivo induction of apoptosis in murine lymphocytes by bacterial lipopolysaccharides, Journal of Medical Microbiology, vol.43, issue.4, pp.251-258, 1995. ,
DOI : 10.1099/00222615-43-4-251
The p38 signal transduction pathway Activation and function, Cellular Signalling, vol.12, issue.1, pp.1-13, 2000. ,
DOI : 10.1016/S0898-6568(99)00071-6
NF-??B in solid tumors, Biochemical Pharmacology, vol.72, issue.9, pp.1142-52, 2006. ,
DOI : 10.1016/j.bcp.2006.07.032
Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes., Proceedings of the National Academy of Sciences, vol.77, issue.10, pp.6129-6162, 1980. ,
DOI : 10.1073/pnas.77.10.6129
Macrophages and antioxidant status in the NOD mouse pancreas, Journal of Cellular Biochemistry, vol.44, issue.4, pp.479-90, 1998. ,
DOI : 10.1002/(SICI)1097-4644(19981215)71:4<479::AID-JCB3>3.0.CO;2-6
Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-??B, The Journal of Immunology, vol.173, issue.6, pp.3589-93, 2004. ,
DOI : 10.4049/jimmunol.173.6.3589
Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512)., Journal of Clinical Investigation, vol.96, issue.3, pp.1506-1517, 1995. ,
DOI : 10.1172/JCI118188
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside, Nature, vol.426, issue.6962, pp.39-44, 2003. ,
DOI : 10.1038/nature02056
Functional Organization of the Human Uncoupling Protein-2 Gene, and Juxtaposition to the Uncoupling Protein-3 Gene, Biochemical and Biophysical Research Communications, vol.255, issue.1, pp.40-46, 1999. ,
DOI : 10.1006/bbrc.1998.0146
Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation, Journal of Biological Chemistry, vol.276, issue.12, pp.8705-8717, 2001. ,
DOI : 10.1074/jbc.M006938200
Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion. Diabetes, 2007. ,
An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds, Biochem J, vol.353, 2001. ,
Stat1-dependent and -independent pathways in IFN-??-dependent signaling, Trends in Immunology, vol.23, issue.2, pp.96-101, 2002. ,
DOI : 10.1016/S1471-4906(01)02118-4
Genetic control of autoimmunity in Type I diabetes and associated disorders, Diabetologia, vol.45, issue.5, pp.605-627, 2002. ,
DOI : 10.1007/s00125-002-0781-1
Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2, The EMBO Journal, vol.18, issue.21, pp.5827-5860, 1999. ,
DOI : 10.1093/emboj/18.21.5827
Mitochondrial protein alteration in active brown fat: A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study, Biochemical and Biophysical Research Communications, vol.73, issue.3, pp.577-83, 1976. ,
DOI : 10.1016/0006-291X(76)90849-4
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP, Biochemical Journal, vol.345, issue.2, pp.161-79, 2000. ,
DOI : 10.1042/bj3450161
Type 1A Diabetes Induced by Infection and Immunization, Journal of Autoimmunity, vol.16, issue.3, pp.355-62, 2001. ,
DOI : 10.1006/jaut.2000.0483
Differential anti-inflammatory and anti-oxidative effects of dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation, Clinical and Experimental Immunology, vol.151, issue.2, pp.249-56, 2000. ,
DOI : 10.1016/0304-419X(91)90007-8
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens, Nature Reviews Molecular Cell Biology, vol.4, issue.5, pp.385-96, 2003. ,
DOI : 10.1038/nrm1104
Islet Abnormalities Associated with an Early Influx of Dendritic Cells and Macrophages in NOD and NODscid Mice, Laboratory Investigation, vol.14, issue.5, pp.769-77, 2000. ,
DOI : 10.1006/jaut.1996.0093
Subsets of Macrophages and Dendritic Cells in Nonobese Diabetic Mouse Pancreatic Inflammatory Infiltrates: Correlation with the Development of Diabetes, Laboratory Investigation, vol.26, issue.1, pp.23-30, 2000. ,
DOI : 10.1038/labinvest.3780004
Production of recombinant cytochrome b558 allows reconstitution of the phagocyte NADPH oxidase solely from recombinant proteins, J. Biol. Chem, vol.268, pp.14256-60, 1993. ,
Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes, Diabetes Care, vol.29, issue.1, pp.89-94, 2006. ,
DOI : 10.2337/diacare.29.01.06.dc05-0757
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice, Genes Dev, vol.14, pp.854-62, 2000. ,
Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-??B and Interleukin-8 Expression, Infection and Immunity, vol.72, issue.4, pp.2123-2153, 2004. ,
DOI : 10.1128/IAI.72.4.2123-2130.2004
Overexpression of Uncoupling Protein 2 in THP1 Monocytes Inhibits ??2 Integrin-Mediated Firm Adhesion and Transendothelial Migration, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.24, issue.5, pp.864-70, 2004. ,
DOI : 10.1161/01.ATV.0000125705.28058.eb
Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion, Diabetes, vol.51, issue.6, pp.1842-50, 2002. ,
DOI : 10.2337/diabetes.51.6.1842
Functions and Mechanisms of Redox Regulation of Cysteine-Based Phosphatases, Antioxidants & Redox Signaling, vol.7, issue.5-6, pp.560-77, 2005. ,
DOI : 10.1089/ars.2005.7.560
BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast, Journal of Biological Chemistry, vol.273, issue.51, pp.34611-34616, 1998. ,
DOI : 10.1074/jbc.273.51.34611
Uncoupling Protein 2 Promoter Polymorphism -866G/A Affects Its Expression in ??-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients, Diabetes, vol.53, issue.2, pp.482-487, 2004. ,
DOI : 10.2337/diabetes.53.2.482
Induction of cystine transport activity in mouse peritoneal macrophages by bacterial lipopolysaccharide, Biochemical Journal, vol.310, issue.2, pp.547-51, 1995. ,
DOI : 10.1042/bj3100547
Essential function for the kinase TAK1 in innate and adaptive immune responses, Nature Immunology, vol.165, issue.11, pp.1087-95, 2005. ,
DOI : 10.1093/intimm/dxf046
Signalinduced degradation of I kappa B alpha requires site-specific ubiquitination, Proc. Natl, 1995. ,
Effects of active MEK1 expression in vivo, Cancer Letters, vol.230, issue.1, pp.1-5, 2005. ,
DOI : 10.1016/j.canlet.2004.12.013
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?, Progress in Lipid Research, vol.45, issue.1, pp.17-41, 2006. ,
DOI : 10.1016/j.plipres.2005.11.001
Interferon-??: an overview of signals, mechanisms and functions, Journal of Leukocyte Biology, vol.75, issue.2, pp.163-89, 2004. ,
DOI : 10.1189/jlb.0603252
mRNA for pancreatic uncoupling protein 2 increases in two models of acute experimental pancreatitis in rats and mice, Cell and Tissue Research, vol.105, issue.2, pp.251-259, 2005. ,
DOI : 10.1007/s00441-004-1024-1
Multiple nuclear factors interact with the immunoglobulin enhancer sequences, Cell, vol.46, issue.5, pp.705-721, 1986. ,
DOI : 10.1016/0092-8674(86)90346-6
Activation by IKKalpha of a Second, Evolutionary Conserved, NF-kappa B Signaling Pathway, Science, vol.293, issue.5534, pp.1495-1504, 2001. ,
DOI : 10.1126/science.1062677
IKK?? Is Essential for Protecting T Cells from TNF??-Induced Apoptosis, Immunity, vol.14, issue.3, pp.217-247, 2001. ,
DOI : 10.1016/S1074-7613(01)00104-2
URL : http://doi.org/10.1016/s1074-7613(01)00104-2
A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects, Diabetes, vol.52, issue.5, pp.1280-1283, 2003. ,
DOI : 10.2337/diabetes.52.5.1280
SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity, The EMBO Journal, vol.265, issue.23, pp.4061-70, 2005. ,
DOI : 10.1038/sj.emboj.7600866
Uncoupling: new approaches to an old problem of bioenergetics, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1363, issue.2, pp.100-124, 1998. ,
DOI : 10.1016/S0005-2728(97)00091-1
Brown fat and thermogenesis, Physiol. Rev, vol.49, pp.330-425, 1969. ,
The Human Uncoupling Protein-3 Gene: GENOMIC STRUCTURE, CHROMOSOMAL LOCALIZATION, AND GENETIC BASIS FOR SHORT AND LONG FORM TRANSCRIPTS, Journal of Biological Chemistry, vol.272, issue.41, pp.25433-25439, 1997. ,
DOI : 10.1074/jbc.272.41.25433
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules, EMBO J, vol.15, pp.2102-2116, 1996. ,
Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain, Journal of Biological Chemistry, vol.277, issue.47, 2002. ,
DOI : 10.1074/jbc.M207217200
Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1413, issue.1, pp.50-54, 1999. ,
DOI : 10.1016/S0005-2728(99)00081-X
URL : http://doi.org/10.1016/s0005-2728(99)00081-x
Mitochondrial proton leak and the uncoupling protein 1 homologues, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1504, issue.1, pp.144-58, 2001. ,
DOI : 10.1016/S0005-2728(00)00243-7
Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic ??-cells overexpressing UCP2, Journal of Endocrinology, vol.183, issue.1, pp.133-177, 2004. ,
DOI : 10.1677/joe.1.05675
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4, Nature, vol.416, issue.6882, pp.750-756, 2002. ,
DOI : 10.1038/nature736
Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic beta Cells Develop Insulin-dependent Diabetes without Insulitis, Journal of Biological Chemistry, vol.273, issue.5, pp.2493-2499, 1998. ,
DOI : 10.1074/jbc.273.5.2493
ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins, J. Physiol, vol.558, pp.123-158 ,
Methods of Detection of Vascular Reactive Species: Nitric Oxide, Superoxide, Hydrogen Peroxide, and Peroxynitrite, Circulation Research, vol.89, issue.3, pp.224-260, 2001. ,
DOI : 10.1161/hh1501.094365
Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-?? production, Journal of Leukocyte Biology, vol.79, issue.6, pp.1348-56, 2006. ,
DOI : 10.1189/jlb.1005613
IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse, Diabetes, vol.53, issue.1, pp.113-134, 2004. ,
DOI : 10.2337/diabetes.53.1.113
Mitogen-activated protein kinase pathways in redox signaling, Frontiers in Bioscience, vol.8, issue.4, pp.369-91, 2003. ,
DOI : 10.2741/999
Generation of Reactive Oxygen Species in the Reaction Catalyzed by ??-Ketoglutarate Dehydrogenase, Journal of Neuroscience, vol.24, issue.36, pp.7771-7779, 2004. ,
DOI : 10.1523/JNEUROSCI.1842-04.2004
Altered membrane trafficking in activated bone marrow-derived macrophages, J. Leukoc. Biol, vol.68, pp.487-94, 2000. ,
Superoxide production by the mitochondrial respiratory chain, Bioscience Reports, vol.17, issue.1, pp.3-8, 1997. ,
DOI : 10.1023/A:1027374931887
Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development, Molecular and Cellular Biology, vol.24, issue.15, pp.6539-6588, 2004. ,
DOI : 10.1128/MCB.24.15.6539-6549.2004
UCP1-independent Thermogenesis in White Adipose Tissue of Cold-acclimated Ucp1-/- Mice, Journal of Biological Chemistry, vol.281, issue.42, 2006. ,
DOI : 10.1074/jbc.M606114200
Integration of Toll-like receptor and phagocytic signaling for tailored immunity, Microbes and Infection, vol.6, issue.15, pp.1368-73, 2004. ,
DOI : 10.1016/j.micinf.2004.08.016
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus, Nature Genetics, vol.44, issue.3, pp.289-92, 1997. ,
DOI : 10.1038/ng0395-293
Streptozotocin, a new antibacterial antibiotic, Antibiot. Annu, vol.7, pp.230-235, 1959. ,
Oxidants and Tyrosine Phosphorylation: Role of Acute and Chronic Oxidative Stress in T-and B-Lymphocyte Signaling, Antioxidants & Redox Signaling, vol.4, issue.3, pp.543-51, 2002. ,
DOI : 10.1089/15230860260196344
N-acetylcysteine Protects Mice from Lethal Endotoxemia by Regulating the Redox State of Immune Cells, Free Radical Research, vol.35, issue.9, pp.919-948, 2003. ,
DOI : 10.1080/1071576031000148727
UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue, Biochemical and Biophysical Research Communications, vol.235, issue.1, pp.79-82, 1997. ,
DOI : 10.1006/bbrc.1997.6740
Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group, Diabetes, vol.49, issue.6, pp.912-919, 2000. ,
DOI : 10.2337/diabetes.49.6.912
Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis, Journal of Molecular Medicine, vol.15, issue.10, pp.806-817, 2005. ,
DOI : 10.1007/s00109-005-0661-5
Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis, The American Journal of Pathology, vol.168, issue.5, pp.1570-1575, 2006. ,
DOI : 10.2353/ajpath.2006.051069
URL : https://hal.archives-ouvertes.fr/hal-00136181
Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function, Diabetes, vol.48, issue.5, pp.1020-1025, 1999. ,
DOI : 10.2337/diabetes.48.5.1020
TAK1 is a ubiquitin-dependent kinase of MKK and IKK, Nature, vol.412, issue.6844, pp.346-51, 2001. ,
DOI : 10.1038/35085597
Modulation of Oxidant and Antioxidant Enzyme Expression and Function in Vascular Cells, Hypertension, vol.44, issue.4, pp.381-387, 2004. ,
DOI : 10.1161/01.HYP.0000142232.29764.a7
Inflammation, stress, and diabetes, Journal of Clinical Investigation, vol.115, issue.5, pp.1111-1120, 2005. ,
DOI : 10.1172/JCI200525102DS1
T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic, Biol. Med, vol.37, pp.1144-51, 2004. ,
DOI : 10.1016/j.freeradbiomed.2004.05.029
Lipopolysaccharide Induces Matrix Metalloproteinase-9 Expression via a Mitochondrial Reactive Oxygen Species-p38 Kinase-Activator Protein-1 Pathway in Raw 264.7 Cells, The Journal of Immunology, vol.173, issue.11, pp.6973-80, 2004. ,
DOI : 10.4049/jimmunol.173.11.6973
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression, Proceedings of the National Academy of Sciences, vol.96, issue.7, pp.3763-3771, 1999. ,
DOI : 10.1073/pnas.96.7.3763
Oxidants Selectively Reverse TGF-?? Suppression of Proinflammatory Mediator Production, The Journal of Immunology, vol.176, issue.2, pp.1209-1226, 2006. ,
DOI : 10.4049/jimmunol.176.2.1209
Uncoupling Protein 2 Promoter Polymorphism -866G/A Affects Peripheral Nerve Dysfunction in Japanese Type 2 Diabetic Patients, Diabetes Care, vol.29, issue.4, pp.888-94, 2006. ,
DOI : 10.2337/diacare.29.04.06.dc05-1984
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1, Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic, pp.337-386, 2002. ,
TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice, Nat. Med, vol.6, pp.556-63, 2000. ,
Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, ?? Cell Dysfunction, and Type 2 Diabetes, Cell, vol.105, issue.6, pp.745-55, 2001. ,
DOI : 10.1016/S0092-8674(01)00378-6
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced ?? cell dysfunction in isolated pancreatic islets, Cell Metabolism, vol.3, issue.6, pp.417-444, 2006. ,
DOI : 10.1016/j.cmet.2006.04.010
The Role of Mitogen-activated Protein Kinase Phosphatase-1 in the Response of Alveolar Macrophages to Lipopolysaccharide: ATTENUATION OF PROINFLAMMATORY CYTOKINE BIOSYNTHESIS VIA FEEDBACK CONTROL OF p38, Journal of Biological Chemistry, vol.280, issue.9, pp.8101-8109, 2005. ,
DOI : 10.1074/jbc.M411760200
Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function, Diabetes, vol.54, issue.5, pp.1423-1431, 2005. ,
DOI : 10.2337/diabetes.54.5.1423
1,2 , Dujardin G. 3 , Emre Y. 1 , Masscheleyn S. 1 , Ricquier D 1 . and Cassard-Doulcier A.M. 1 * FEBS Letters, pp.479-82, 2007. ,
Present adress: INSERM ,
Louis Casteilla et le Pr Francesc Villarroya pour avoir accepté d'être rapporteur, ainsi que le Dr ,
je me suis dit à ton départ que j'allais enfin être tranquille. Mais en réalité ce fut fort ennuyeux, tu le sais. Et ce ne sont pas les départs successifs de François et Tobias qui ont arrangé les choses. C'est évidemment pour cette unique raison que j'a voulu tenter la STZ. Sinon, comment aurions-nous pu nous voir ? Dans quelques semaines, j'espère que tu n'oublieras pas de m'envoyer ton Nat ,
avais déjà abandonné une première fois et maintenant, j'apprends que tu as succombé au côté obscur de la force ! J'en suis heureux pour toi, tu le mérites amplement ,
ton aide et nos discussions ont été précieuses. Bientôt, tu seras le group leader aux multiples Nature et tu n'auras plus à errer de labo en labo. D'ici là, bon courage Je regrette que cette complicité ne s'est pas développée plus rapidement ,