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A. 3. Application, . To, and A. Data-figure, 1: Test of the method for the IF model Each panel presents a scan in the (g e0 , g i0 )?plane. Color codes the relative deviation between model parameters and their estimates using the method (note the different scales for means/SDs) A: deviation in the mean of excitatory conductance (g e0 ) B: Same as A for inhibition. C: deviation in the SD of excitatory conductanceD: Same as C for inhibition, general the method works fine, except for a small band in the case of inhibitory SD

A. Figure, White noise in the voltage trace significantly impairs the reliability of the method. The relative deviation in the estimation of g e0 and g i0 (upper panel) as well as ? e and ? i is given as a function of the white noise amplitude. Different curves correspond to different pairs (g e0 , g i0 ) While the noise has an opposite effect on the estimation of the mean conductance values

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