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Theses

Interaction between synaptic conductances and action
potential initiation in cortical neurons: computational
models and analysis of intracellular recordings

Abstract : During natural network states in vivo, neocortical neurons are subject to a high and fluctuating membrane conductance. However, the integrative properties of neurons during such “high-conductance” (HC) states are still unknown. We have (1) characterized the link between conductance dynamics and action potential (AP) initiation in HC states; (2) compared different models of AP response (PSTH) during such states. We distinguish two discharge modes, according to whether the AP is evoked by an increase of excitation or by a decrease of inhibition. We have proposed a new method to calculate the “spike-triggered average” (STA) of conductances solely from the Vm, tested this method numerically and in vitro, as well as applied this method to in vivo recordings. We demonstrate that inhibitory APs are predominant in the awake cat, which reveals a major role for inhibition.
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https://tel.archives-ouvertes.fr/tel-00180968
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Submitted on : Monday, October 22, 2007 - 3:43:47 PM
Last modification on : Wednesday, December 9, 2020 - 3:07:48 PM
Long-term archiving on: : Monday, June 27, 2011 - 3:45:07 PM

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  • HAL Id : tel-00180968, version 1

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Martin Pospischil. Interaction between synaptic conductances and action
potential initiation in cortical neurons: computational
models and analysis of intracellular recordings. Neurons and Cognition [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2007. English. ⟨tel-00180968⟩

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