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Complexes de lanthanides(III) pour le développement de nouvelles sondes magnétiques et luminescentes

Aline M. Nonat 1 
1 RICC - Reconnaissance Ionique et Chimie de Coordination
SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé : DRF/INAC/SYMMES
Abstract : The simultaneous optimisation of the molecular parameters determining the relaxivity (number of coordinated water molecules, water-exchange, rotation dynamics of the whole complex, electronic relaxation, Gd(III)-proton distance) is essential to prepare efficient contrast agents. The aim of this work is on the one hand to design and study complexes with a high number of bound water molecules and to understand the influence of the coordination sphere on the stability and on the electronic relaxation and on the other hand, to use the ligand as a chromophor for the development of luminescent probes for biomedical imaging.
We present the structure, the stability and the relaxivity of Gd(III) complexes of two series of tripodal ligands containing picolinate units based either on the 1,4,7-triazacyclononane ring or on a tertiary amine. These complexes show high relaxivity in water and in serum and can establish a non covalent interaction with serum albumin. The interpretation of the water proton relaxivity with the help of new relaxometric methods based on an auxiliary probe solute has allowed us to show that both the presence of the picolinate groups and the 1,4,7-triazacyclononane framework can lead to Gd(III) complexes with favourable electronic relaxation properties.
This ligands have also been used for Eu(III) and Tb(III) complexation leading to strong luminescence in visible light. Other complexes derived from 8-hydroxyquinoline unit which display a very high luminescence in infrared are also studied.
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Submitted on : Saturday, October 13, 2007 - 11:58:14 AM
Last modification on : Friday, March 25, 2022 - 11:10:32 AM
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  • HAL Id : tel-00179133, version 1



Aline M. Nonat. Complexes de lanthanides(III) pour le développement de nouvelles sondes magnétiques et luminescentes. Autre. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00179133⟩



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