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L'expression séquentielle des calciprotéines S100A1 et SB100B dans les cellules gliales du système nerveux central caractérise différents stades développementaux en relation avec leurs potentialités de différenciation

Abstract : Adult neural precursors possess a cellular plasticity reflecting their possible role in disease and for treating neurological illness. However, we need to truly understand the biological mecanisms governing these cells in order to use them in futur cellular therapy. In this thesis, we have studied the S100 A1 and B expression pattern both in oligodendrocyte progenitor cells and in astrocytic neural stem cells. We demonstrate that
1) all glial cells precociously express S100A1 whereas S100B appearence is only linked to their maturation step
2) S100B is a molecular actor regulating OPC maturation
3) in adult brain, astrocytic neural stem cells are maintained in a S100B- immature developmental stage to preserve their potential via an EGF microenvironnemental pathway.
Altogether, these results highlight a link between S100A1/B proteins, glial cells maturation and cellular plasticity.
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Theses
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https://tel.archives-ouvertes.fr/tel-00178904
Contributor : Pascal Martinez <>
Submitted on : Tuesday, October 16, 2007 - 10:59:39 AM
Last modification on : Friday, November 6, 2020 - 4:07:29 AM
Long-term archiving on: : Sunday, April 11, 2010 - 10:54:18 PM

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  • HAL Id : tel-00178904, version 1

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Éric Raponi. L'expression séquentielle des calciprotéines S100A1 et SB100B dans les cellules gliales du système nerveux central caractérise différents stades développementaux en relation avec leurs potentialités de différenciation. Sciences du Vivant [q-bio]. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00178904⟩

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