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Analyse et modélisation des dépendances entre sites voisins dans l'évolution des séquences d'ADN

Leonor Palmeira 1
1 Baobab
PEGASE - Département PEGASE [LBBE]
Abstract : On the one hand, this study examined dinucleotide over- and under-representations in different complete genomes, in order to determine possible links with DNA damage known mechanims. We focused on direct 5' and 3' neighbors, and analyzed the effect of UV light on the genomes of micro-organisms, and the effect of methylation on the genomes of metazoans. On the other hand, recent results by Bérard et al. on models of evolution incorporating neighboring site dependencies (pyrimidine followed by purine), allowed us to develop a probabilistic approach for the estimation of substitution rates due to the methylation-deamination process acting on CG dinucleotides.
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https://tel.archives-ouvertes.fr/tel-00178453
Contributor : Leonor Palmeira <>
Submitted on : Thursday, October 11, 2007 - 11:28:48 AM
Last modification on : Monday, February 10, 2020 - 4:36:55 PM
Long-term archiving on: : Monday, September 24, 2012 - 1:16:29 PM

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  • HAL Id : tel-00178453, version 1

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Leonor Palmeira. Analyse et modélisation des dépendances entre sites voisins dans l'évolution des séquences d'ADN. Autre [q-bio.OT]. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00178453⟩

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