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Theses

Microscopie locale par résonance magnétique chez l'homme et le petit animal à l'aide d'antennes miniatures en cuivre ou en céramique supraconductrice

Abstract : There is significant interest to combine local microscopy magnetic resonance imaging (MRI) with biomedical research on human body (skin, peripheral articulations) and on small animal models. But this imaging technique faces a critical lack of sensitivity. The improvement of radiofrequency detection, through the development of small surface coils and optimised electronics, is an efficient way to provide the sensitivity needed to increase the spatial resolution, while preserving a high signal to noise ratio (SNR).
Small coils made of copper or high temperature superconductor (HTS), were designed following the transmission line principal and fabricated using microtechnologies. They were characterised electrically and by imaging in order to evaluate their performance.
We investigated different biomedical applications that were opened by the gain in sensitivity with our HTS coils at the standard field in MRI of 1.5 T. This new approach
allowed to access isotropic voxels down to (60 µm)3
on explored regions such as peripheral human areas or various mouse sites, with an SNR 4 to 15 times better than the one reached with an analogous room-temperature copper coil.
The accessible resolutions are comparable to those usually obtained at much higher fields where the imaging environment is more complex and more expensive. For several biomedical issues, imaging at 1.5 T with HTS coils can offer a true alternative to high field
.
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https://tel.archives-ouvertes.fr/tel-00175845
Contributor : Marie Poirier-Quinot <>
Submitted on : Monday, October 1, 2007 - 3:01:48 PM
Last modification on : Friday, November 6, 2020 - 4:04:03 PM
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Marie Poirier-Quinot. Microscopie locale par résonance magnétique chez l'homme et le petit animal à l'aide d'antennes miniatures en cuivre ou en céramique supraconductrice. Physique [physics]. Université Paris Sud - Paris XI, 2004. Français. ⟨tel-00175845⟩

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