L. Ratti, G. Rigon, A. Tromba, E. Vacchi, F. Vallazza et al., Mammography with synchrotron radiation: phase-detection techniques, Radiology, vol.215, issue.1, pp.286-93, 2000.

N. Bellamy, J. Kirwan, M. Boers, P. Brooks, V. Strand et al., Recommendations for a core set of outcome measures for future Phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III, J Rheumatol, vol.24, pp.799-802, 1997.

F. E. Carroll, M. H. Mendenhall, R. H. Traeger, C. Brau, and J. W. Waters, New Opportunities, American Journal of Roentgenology, vol.181, issue.5, 2003.
DOI : 10.2214/ajr.181.5.1811197

P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel et al., Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction, Journal of Synchrotron Radiation, vol.12, issue.2, pp.241-245, 2005.
DOI : 10.1107/S0909049504028444

M. Dougados, Monitoring osteoarthritis progression and therapy11Supported by Procter & Gamble Pharmaceuticals, Mason, OH, Osteoarthritis and Cartilage, vol.12, pp.55-60, 2004.
DOI : 10.1016/j.joca.2003.09.009

C. Gordon, C. Wu, C. Petrefy, J. Li, J. Duryea et al., Automated measurement of radiographic hip joint-space width, Medical Physics, vol.8, issue.2, pp.267-277, 2001.
DOI : 10.1118/1.1344202

M. Elo, P. Tenhunen, W. Suortti, and . Thomlinson, Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology, European Journal of Radiology, vol.53, pp.226-237, 2005.

A. Kuettner, L. D. Margulis, and . Chapman, Diffraction-enhanced X-ray imaging of articular cartilage, Osteoarthritis and cartilage, vol.10, pp.163-171, 2002.

C. Muehleman, S. Majumdar, A. Issever, F. Arfelli, R. Menk et al., X-ray detection of structural orientation in human articular cartilage, Osteoarthritis and Cartilage, vol.12, issue.2, pp.97-105, 2004.
DOI : 10.1016/j.joca.2003.10.001

E. Pagot, Quantitative comparison between two phase contrast techniques for mammography: diffraction enhanced imaging (DEI) and phase propagation imaging (PPI), 2004.

G. Dreiser, A. Herrero-beaumont, G. Kahan, A. Kreutz, E. M. Laslop et al., Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis, Osteoarthritis and cartilage, vol.12, pp.263-268, 2004.

L. Ratti, G. Rigon, A. Tromba, E. Vacchi, F. Vallazza et al., Mammography with synchrotron radiation: phase-detection techniques, Radiology, vol.215, issue.1, pp.286-93, 2000.

A. Bashir, M. Gray, J. Harke, and D. Burstein, Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI, Magnetic Resonance in Medicine, vol.39, issue.5, pp.857-865, 1999.
DOI : 10.1002/(SICI)1522-2594(199905)41:5<857::AID-MRM1>3.0.CO;2-E

N. Bellamy, J. Kirwan, M. Boers, P. Brooks, V. Strand et al., Recommendations for a core set of outcome measures for future Phase III clinical trials in knee, hip, and hand osteoarthritis.Consensus development at OMERACT III, J Rheumatol, vol.24, pp.799-802, 1997.

S. Biswal, T. Hastie, T. Andriacchi, G. Bergman, M. Dillingham et al., Risk factors for progressive cartilage loss in the knee, Arthritis & Rheumatism, vol.185, issue.11, pp.2884-2892, 2002.
DOI : 10.1002/art.10573

M. Born and E. Wolf, Principles of optics: electromagnetic theory of propagation, interference and diffraction of light, 1999.
DOI : 10.1017/CBO9781139644181

K. Brandt, S. Mazucca, T. Conrozier, J. Dacre, C. Peterfy et al., What is the best radiographic protocol for a clinical trial of a structure modifying drug in patients with osteoarthritis, J Rheumatol, vol.29, pp.1308-1320, 2002.

A. Bravin, S. Fiedler, and W. C. Thomlinson, <title>Very-low-dose mammography: new perspectives in diffraction enhanced imaging (DEI) mammography</title>, Medical Imaging 2002: Physics of Medical Imaging, 2002.
DOI : 10.1117/12.465555

O. Bruyere, J. Collette, O. Ethgen, L. Rovati, G. Giacovelli et al., Biochemical markers of bone and cartilage remodeling in prediction of long term progression of knee osteoarthritis, J Rheumatol, vol.30, pp.1043-1050, 2003.

F. Cicuttini, A. Wluka, A. Forbes, and R. Wolfe, Comparison of tibial cartilage volume and radiologic grade of the tibiofemoral joint, Arthritis & Rheumatism, vol.55, issue.3, pp.682-688, 2003.
DOI : 10.1002/art.10840

D. H. Collins, Osteoarthritis. The Pathology of Articular and Spinal Diseases, E. Arnold, pp.74-115, 1949.

T. Conrozier, M. Lequesne, H. Favret, A. Taccoen, B. Mazieres et al., Measurement of the radiological hip joint space width. An evaluation of various methods of measurement, Osteoarthritis and Cartilage, vol.9, issue.3, pp.281-286, 2001.
DOI : 10.1053/joca.2000.0386

M. Dougados, Monitoring osteoarthritis progression and therapy11Supported by Procter & Gamble Pharmaceuticals, Mason, OH, Osteoarthritis and Cartilage, vol.12, pp.55-60, 2004.
DOI : 10.1016/j.joca.2003.09.009

URL : http://doi.org/10.1016/j.joca.2003.09.009

D. Gale, C. Chaisson, S. Totterman, R. Schwartz, M. Gale et al., Meniscal subluxation: association with osteoarthritis and joint space narrowing, Osteoarthritis and Cartilage, vol.7, issue.6, pp.526-532, 1999.
DOI : 10.1053/joca.1999.0256

URL : http://doi.org/10.1053/joca.1999.0256

S. Gandy, P. Dieppe, M. Keen, R. Maciewic, I. Watt et al., No loss of cartilage volume over three years in patients with knee osteoarthritis as assessed by magnetic resonance imaging, Osteoarthritis and Cartilage, vol.10, issue.12, pp.929-937, 2002.
DOI : 10.1053/joca.2002.0849

C. Gordon, C. Wu, C. Petrefy, J. Li, J. Duryea et al., Automated measurement of radiographic hip joint-space width, Medical Physics, vol.8, issue.2, pp.267-277, 2001.
DOI : 10.1118/1.1344202

W. R. Hedrick, D. L. Hykes, and D. E. Starchman, Ultrasound Physics and Instrumentation, 1995.

G. T. Herman, Image reconstruction from projections, 1980.
DOI : 10.1006/rtim.1995.1002

G. N. Hounsfield, Computerized transverse axial scanning (tomography): Part 1. Description of system, The British Journal of Radiology, vol.46, issue.552, p.1016, 1973.
DOI : 10.1259/0007-1285-46-552-1016

A. C. Kak and M. Slaney, Principles of Computerized Tomographic Imaging, 1988.

M. Elo, P. Tenhunen, W. Suortti, and . Thomlinson, Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology, European Journal of Radiology, vol.53, pp.226-237, 2005.

C. Liess, S. Lussert, N. Karger, M. Heller, and C. Gluer, Detection of changes in cartilage water content using MRI T2-mapping in vivo, Osteoarthritis and Cartilage, vol.10, issue.12, pp.907-913, 2002.
DOI : 10.1053/joca.2002.0847

T. Link, L. Steinbach, P. Ghosh, M. Ries, Y. Lu et al., Osteoarthritis: MR Imaging Findings in Different Stages of Disease and Correlation with Clinical Findings, Radiology, vol.226, issue.2, pp.373-381, 2003.
DOI : 10.1148/radiol.2262012190

L. S. Lohmander and D. Felson, Can we identify a ???high risk??? patient profile to determine who will experience rapid progression of osteoarthritis?11Supported by the Swedish Research Council (Medicine) and NIH AR47785., Osteoarthritis and Cartilage, vol.12, pp.49-52, 2004.
DOI : 10.1016/j.joca.2003.09.004

S. Mazucca, K. Brandt, and K. Buckwalter, Detection of radiographic joint space narrowing in subjects with knee osteoarthritis: Longitudinal comparison of the metatarsophalangeal and semiflexed anteroposterior views, Arthritis & Rheumatism, vol.46, issue.2, pp.385-390, 2003.
DOI : 10.1002/art.10765

A. Kuettner, L. D. Margulis, and . Chapman, Diffraction-enhanced X-ray imaging of articular cartilage, Osteoarthritis and cartilage, vol.10, pp.163-171, 2002.

J. Mollenhauer and K. E. Kuettner, Articular Cartilage. Principles of Orthopaedic Practice, 1997.

T. Mosher, B. Dardzinski, and M. Smith, Human Articular Cartilage: Influence of Aging and Early Symptomatic Degeneration on the Spatial Variation of T2???Preliminary Findings at 3 T, Radiology, vol.214, issue.1, pp.259-266, 2000.
DOI : 10.1148/radiology.214.1.r00ja15259

M. Nieminen, J. Rieppo, J. Toyras, M. Hakumaki, J. Silvennoinen et al., relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study, Magnetic Resonance in Medicine, vol.60, issue.3, pp.487-493, 2001.
DOI : 10.1002/mrm.1218

E. Pessis, J. Drape, P. Ravaud, A. Chevrot, M. Dougados et al., Assessment of progression in knee osteoarthritis: results of a 1 year study comparing arthroscopy and MRI, Osteoarthritis and Cartilage, vol.11, issue.5, pp.361-369, 2003.
DOI : 10.1016/S1063-4584(03)00049-9

J. Raynaud, C. Kauffman, G. Beaudoins, M. Berthaumie, J. De-guise et al., Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees, Osteoarthritis and Cartilage, vol.11, issue.5, pp.351-360, 2003.
DOI : 10.1016/S1063-4584(03)00029-3

R. Regatte, S. Akella, R. Borthakur, and R. Reddy, Proton spin-lock ratio imaging for quantitation of glycosaminoglycans in articular cartilage, Journal of Magnetic Resonance Imaging, vol.53, issue.1, pp.114-121, 2003.
DOI : 10.1002/jmri.10228

K. K. Shung, M. B. Smith, and B. Tsui, Principles of medical imaging, 1992.

T. D. Spector and A. J. Macgregor, Risk factors for osteoarthritis: genetics11Supported by Procter & Gamble Pharmaceuticals, Mason, OH, Osteoarthritis and Cartilage, vol.12, pp.39-44, 2004.
DOI : 10.1016/j.joca.2003.09.005

C. Tiderius, L. Olson, P. Leander, O. Ekberg, and L. Dahlberg, Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis, Magnetic Resonance in Medicine, vol.1, issue.4, pp.488-492, 2003.
DOI : 10.1002/mrm.10389

P. Reime, A. Coan, F. Bravin, G. Arvelli, R. Heitner et al., Options and Limitations of Joint Cartilage Imaging: DEI in Comparison to MRI and Sonography, Nucl. Instr. Meth. A, vol.548, pp.47-53, 2005.

S. Webb, The physics of medical imaging. F. Mould, 1988.

M. Ando, H. Sugiyama, A. Maksimenko, W. Pattanasiriwisawa, K. Hyodo et al., A New Optics for Dark-Field Imaging in X-Ray Region `Owl', Japanese Journal of Applied Physics, vol.40, issue.Part 2, No. 8A, pp.844-846, 2001.
DOI : 10.1143/JJAP.40.L844

G. Rigon, A. Tromba, E. Vacchi, F. Vallazza, and . Zanconati, Mammography with synchrotron radiation: phase-detection techniques, Radiology, vol.215, issue.1, pp.286-93, 2000.

S. Olivo, P. Pani, M. Poropat, F. Prest, L. Rashevsky et al., Improvements in the field of radiological imaging at the SYRMEP beamline. Medical Applications of Penetrating Radiation, 1999.

B. D. Arhatari, A. P. Mancuso, A. G. Peele, and K. A. Nugent, Phase contrast radiography: Image modeling and optimization, Review of Scientific Instruments, vol.75, issue.12, pp.75-5271, 2004.
DOI : 10.1063/1.1819652

A. Authier, Dynamical theory of X -ray diffraction, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00130752

P. Becker and U. Bonse, The skew-symmetric two-crystal X-ray interferometer, Journal of Applied Crystallography, vol.7, issue.6, pp.593-598, 1974.
DOI : 10.1107/S0021889874010491

F. Beckmann, U. Bonse, F. Busch, and O. Günnewig, X-Ray Microtomography (??CT) Using Phase Contrast for the Investigation of Organic Matter, Journal of Computer Assisted Tomography, vol.21, issue.4, p.539, 1997.
DOI : 10.1097/00004728-199707000-00006

U. Bonse and F. Busch, X-ray computed microtomography (microCT) using synchrotron radiation (SR), Prog Biophys Mol Biol, pp.65-66, 1996.
DOI : 10.1016/s0079-6107(96)00011-9

U. Bonse and M. Hart, AN X???RAY INTERFEROMETER, Applied Physics Letters, vol.6, issue.8, pp.155-156, 1965.
DOI : 10.1063/1.1754212

M. Born and E. Wolf, Principles of optics: electromagnetic theory of propagation, interference and diffraction of light, 1999.
DOI : 10.1017/CBO9781139644181

A. Bravin, Exploiting the x-ray refraction contrast with an analyser: the state of the art, Journal of Physics D: Applied Physics, vol.36, issue.10A, pp.24-29, 2003.
DOI : 10.1088/0022-3727/36/10A/306

A. Bravin, V. Mocella, C. Ferrero, P. Coan, S. Fiedler et al., A wavefront propagation approach to Diffraction Imaging

V. Bushuev, E. Beliaevskaya, and V. Ingal, Wave-optical description of X-ray phase contrast images of weakly absorbing non-crystalline objects, Il Nuovo Cimento D, vol.266, issue.2-4, pp.513-520, 1997.
DOI : 10.1007/BF03041011

D. Chapman, W. Thomlinson, F. Arfelli, N. Gmur, Z. Zhong et al., Mammography imaging studies using a Laue crystal analyzer, Review of Scientific Instruments, vol.67, issue.9, pp.1-5, 1996.
DOI : 10.1063/1.1147502

D. Arfelli and . Sayers, Diffraction enhanced x-ray imaging, Phys Med Biol, vol.42, issue.11, pp.2015-2040, 1997.

P. Cloetens, Contribution to Phase Contrast Imaging, Reconstruction and Tomography with hard Synchrotron Radiation. Principles, Implementation and Applications, p.77, 1999.

P. Cloetens, R. Barrett, J. Baruchel, J. Guigay, and M. Schlenker, Phase objects in synchrotron radiation hard x-ray imaging, Journal of Physics D: Applied Physics, vol.29, issue.1, pp.133-146, 1996.
DOI : 10.1088/0022-3727/29/1/023

P. Cloetens, W. Ludwig, E. Boller, F. Peyrin, M. Schlenker et al., 3D IMAGING USING COHERENT SYNCHROTRON RADIATION, Image Analysis & Stereology, vol.21, issue.4, pp.75-85, 2002.
DOI : 10.5566/ias.v21.pS75-S85

URL : https://doaj.org/article/60fc4c0e764e44e5be170738ddc5082c

P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel et al., Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction, Journal of Synchrotron Radiation, vol.12, issue.2, pp.241-245, 2005.
DOI : 10.1107/S0909049504028444

R. Cusack, J. M. Huntley, and H. T. Goldrein, Improved noise-immune phase-unwrapping algorithm, Applied Optics, vol.34, issue.5, p.781, 1995.
DOI : 10.1364/AO.34.000781

C. David, B. Nohammer, H. Solak, and E. Ziegler, Differential x-ray phase contrast imaging using a shearing interferometer, Applied Physics Letters, vol.81, issue.17, pp.3287-3289, 2002.
DOI : 10.1063/1.1516611

T. Davis, X-Ray Diffraction Imaging Using Perfect Crystals, Journal of X-Ray Science and Technology, vol.6, issue.4, pp.317-342, 1996.
DOI : 10.1006/jxra.1996.0021

T. Davis, D. Gao, T. Gureyev, A. Stevenson, and S. Wilkins, Phase-contrast imaging of weakly absorbing materials using hard X-rays, Nature, vol.373, issue.6515, pp.595-598, 1995.
DOI : 10.1038/373595a0

T. Davis, T. Gureyev, D. Gao, A. Stevenson, and S. Wilkins, X-Ray Image Contrast from a Simple Phase Object, Physical Review Letters, vol.74, issue.16, pp.74-3173, 1995.
DOI : 10.1103/PhysRevLett.74.3173

R. Fitzgerald, Phase???Sensitive X???Ray Imaging, Physics Today, vol.53, issue.7, p.23, 2000.
DOI : 10.1063/1.1292471

E. Förster, K. Goetz, and P. Zaumseil, Double crystal diffractometry for the characterization of targets for laser fusion experiments, Kristall und Technik, vol.18, issue.8, pp.937-945, 1980.
DOI : 10.1002/crat.19800150812

A. G. Frodesen, O. Skjeggestad, and H. Tofte, Probability and statistics in particle physics, 1979.

J. P. Guigay, E. Pagot, and P. Cloetens, Fourier optics approach to X-ray analyzer-based imaging

T. Gureyev and S. Wilkins, Regimes of X-ray phase-contrast imaging with perfect crystals, Il Nuovo Cimento D, vol.13, issue.2-4, pp.19-21, 1997.
DOI : 10.1007/BF03041015

T. Gureyev, T. J. Davis, A. Pogany, S. C. Mayo, and S. W. Wilkins, Optical phase retrieval by use of first Born- and Rytov-type approximations, Applied Optics, vol.43, issue.12, pp.2418-2430, 2004.
DOI : 10.1364/AO.43.002418

T. Gyreyev, C. Raven, A. Snigirev, I. Snigireva, and S. Wilkins, Hard x-ray quantitative noninterferometric phase-contrast microscopy, J Phys D: Appl Phys, vol.32, 1999.

M. O. Hasnah, C. Parham, E. D. Pisano, Z. Zhong, O. Oltulu et al., Mass density images from the diffraction enhanced imaging technique, Medical Physics, vol.29, issue.7, pp.549-552, 2005.
DOI : 10.1118/1.1852794

B. Henke, E. Gullikson, and J. Davis, X-Ray Interactions: Photoabsorption, Scattering, Transmission, and Reflection at E = 50-30,000 eV, Z = 1-92, Atomic Data and Nuclear Data Tables, vol.54, issue.2, pp.181-342, 1993.
DOI : 10.1006/adnd.1993.1013

O. Hignette, P. Cloetens, W. Lee, W. Ludwig, and G. Rostaing, Hard X-ray microscopy with reflecting mirrors status and perspectives of the ESRF technology, Journal de Physique IV (Proceedings), vol.104, pp.231-234, 2003.
DOI : 10.1051/jp4:200300068

V. Ingal and E. Beliaevskaya, Phase dispersion radiography of biological objects, Physica Medica XII, issue.2, pp.75-81, 1996.

V. Ingal and E. Beliaevskaya, Phase Dispersion Introscopy, Surface Investigation, vol.12, pp.441-450, 1997.
DOI : 10.1134/1.1258639

M. Born and E. Wolf, Principles of optics: electromagnetic theory of propagation, interference and diffraction of light, 1999.
DOI : 10.1017/CBO9781139644181

W. Brefeld and P. Gurtler, Synchrotron Radiation Sources. Handbook on Synchrotron Radiation, 1991.

J. Bushber, The essential physics of medical imaging, 1994.

F. E. Carroll, M. H. Mendenhall, R. H. Traeger, C. Brau, and J. W. Waters, New Opportunities, American Journal of Roentgenology, vol.181, issue.5, 2003.
DOI : 10.2214/ajr.181.5.1811197

P. Cloetens, Contribution to Phase Contrast Imaging, Reconstruction and Tomography with hard Synchrotron Radiation. Principles, Implementation and Applications, 1999.

P. Spanne, W. Suortti, F. Thomlinson, B. Esteve, J. Bertrand et al., Instrumentation of the ESRF medical imaging facility, Nucl. Instr. and Meth. A, vol.428, pp.513-527, 1999.

A. Fukasawa, H. Iijima, M. Uesaka, J. Urakawa, T. Higo et al., Compact hard X-ray source via inverse Compton scattering based on the X-band LINAC, Proceedings of the Second Asian Particle Accelerator Conference, 2001.

G. Margaritondo, Y. Hwu, and G. Tromba, Synchrotron light: from basics to coherence and coherence-related applications Lezioni della VI scuola nazionale di luce di sincrotrone S, 2001.

A. Peterzol, A. Bravin, P. Coan, and H. Elleaume, Image quality evaluation of the angiography imaging system at the European synchrotron radiation facility, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.510, issue.1-2, pp.45-50, 2003.
DOI : 10.1016/S0168-9002(03)01677-2

W. Röntgen, Über eine neue Art von Strahlen Sitzungberichte der physikalisch-medizinischen Gesellschaft, Physics and Medical Society, pp.132-141, 1895.

P. Suortti and W. Thomlinson, Medical applications of synchrotron radiation, Physics in Medicine and Biology, vol.48, issue.13, pp.1-35, 2003.
DOI : 10.1088/0031-9155/48/13/201

S. Wilkins, T. Gureyev, D. Gao, A. Pogani, and A. Stevenson, Phase-contrast imaging using polychromatic hard X-rays, Nature, vol.384, issue.6607, pp.335-338, 1996.
DOI : 10.1038/384335a0

P. Chopper-control, MTF evaluation of the, p.144

R. G. Borasi, A. Nitrosi, P. Ferrari, and D. Tassoni, On site evaluation of three flat panel detectors for digital radiography, Medical Physics, vol.24, issue.7, pp.1719-1731, 2003.
DOI : 10.1118/1.1569273

S. Corde, Enhancement of the photo-electric effect with pharmacological agents in synchrotron radiation based anti cancer radiotherapy: a methodological study, 2002.
URL : https://hal.archives-ouvertes.fr/tel-00006585

I. Cunningham, Applied Linear-Systems Theory. Handbook of Medical Imaging, Medical Physics and Psychophysics, pp.79-159, 2000.
DOI : 10.1117/3.832716.ch2

I. Cunningham and A. Fenster, A method for modulation transfer function determination from edge profiles with correction for finite-element differentiation, Medical Physics, vol.14, issue.4, pp.533-537, 1987.
DOI : 10.1118/1.596064

J. T. Dobbins, Image Quality Metrics for Digital Systems. Handbook of Medical Imaging, Medical Physics and Psychophysics, pp.161-221, 2000.

J. T. Dobbins, D. Ergun, L. Rutz, D. Hinshaw, H. Blume et al., ) of four generations of computed radiography acquisition devices, Medical Physics, vol.22, issue.10, pp.22-1581, 1995.
DOI : 10.1118/1.597627

H. Fujita, K. Doi, and M. Giger, Investigation of basic imaging properties in digital radiography, 1985.

A. L. Goertzen, V. Nagarkar, R. A. Street, M. J. Paulus, J. M. Boone et al., A comparison of x-ray detectors for mouse CT imaging, Physics in Medicine and Biology, vol.49, issue.23, pp.5251-5265, 2004.
DOI : 10.1088/0031-9155/49/23/004

P. R. Granfors and R. Aufrichtig, Performance of a 41??41-cm2 amorphous silicon flat panel x-ray detector for radiographic imaging applications, Medical Physics, vol.11, issue.6, pp.1324-1331, 2000.
DOI : 10.1118/1.599010

P. Greer and T. Van-doorn, Evaluation of an algorithm for the assessment of the MTF using an edge method, Medical Physics, vol.19, issue.9, pp.2048-2059, 2000.
DOI : 10.1118/1.1288682

H. Johns and J. Cunningam, The physics of radiology, 1971.

A. Peterzol, A. Bravin, P. Coan, and H. Elleaume, Image quality evaluation of the angiography imaging system at the European synchrotron radiation facility, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.510, issue.1-2, pp.45-50, 2003.
DOI : 10.1016/S0168-9002(03)01677-2

W. C. Phillips, A. Stewart, M. Stanton, I. Naday, and C. Ingersoll, High-sensitivity CCD-based X-ray detector, Journal of Synchrotron Radiation, vol.9, issue.1, pp.36-43, 2002.
DOI : 10.1107/S0909049501020143

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.522.5075

M. Renier, S. Fiedler, C. Nemoz, H. Gonzalez, G. Berruyer et al., A mechanical chopper with continuously adjustable duty cycle for a wide X-ray beam, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.548, issue.1-2, pp.111-115, 2005.
DOI : 10.1016/j.nima.2005.03.076

E. Samei, Image quality in two phosphor-based flat panel digital radiographic detectors, Medical Physics, vol.28, issue.7, 2003.
DOI : 10.1118/1.1578772

E. Samei and M. Flynn, An experimental comparison of detector performance for direct and indirect digital radiography systems, Medical Physics, vol.3977, issue.4, pp.608-622, 2003.
DOI : 10.1118/1.1561285

E. Samei, M. Flynn, and D. Reiman, A method for measuring the presampled MTF of digital radiographic systems using an edge test device, Medical Physics, vol.11, issue.1, pp.102-113, 1998.
DOI : 10.1118/1.598165

M. Tapiovaara and R. Wagner, SNR and noise measurements for medical imaging: I. A practical approach based on statistical decision theory, Physics in Medicine and Biology, vol.38, issue.1, pp.71-92, 1993.
DOI : 10.1088/0031-9155/38/1/006

S. Vedantham, A. Karellas, S. Suryanarayanan, I. Levis, M. Sayag et al., Mammographic imaging with a small format CCD-based digital cassette: Physical characteristics of a clinical system, Medical Physics, vol.3032, issue.P, pp.1832-1840, 2000.
DOI : 10.1118/1.1286720

M. Williams, P. Mangiafico, and P. Simoni, Noise power spectra of images from digital mammography detectors, Medical Physics, vol.2163, issue.7, pp.1279-1293, 1999.
DOI : 10.1118/1.598623

N. Yagi, I. Katsuaki, and T. Oka, CCD-based X-ray area detector for time-resolved diffraction experiments, Journal of Synchrotron Radiation, vol.11, issue.6, pp.456-461, 2004.
DOI : 10.1107/S090904950402093X

N. Yagi, M. Yamamoto, K. Uesugi, and K. Inoue, A large-area CMOS imager as an X-ray detector for synchrotron radiation experiments, Journal of Synchrotron Radiation, vol.11, issue.4, pp.347-352, 2004.
DOI : 10.1107/S0909049504008519

A. Color-coded and .. , 166 5.5 Results of the in-vitro experiments

A. Bravin, S. Fiedler, and W. C. Thomlinson, <title>Very-low-dose mammography: new perspectives in diffraction enhanced imaging (DEI) mammography</title>, Medical Imaging 2002: Physics of Medical Imaging, 2002.
DOI : 10.1117/12.465555

R. A. Brooks and G. D. Chiro, Beam hardening in X-ray reconstructive tomography, Physics in Medicine and Biology, vol.21, issue.3, pp.390-398, 1976.
DOI : 10.1088/0031-9155/21/3/004

J. Dainty and R. Shaw, Image science, 1974.

F. Delmas, V. Trocheris, C. Miro, J. Murat, and I. Villaescusa, Expression of stress proteins in cultured human cells as a sensitive indicator of metal toxicity, Analytical and Bioanalytical Chemistry, vol.354, issue.5-6, pp.615-619, 1996.
DOI : 10.1007/s0021663540615

E. R. Foster and J. A. Downs, Histone H2A phosphorylation in DNA double-strand break repair, FEBS Journal, vol.20, issue.13, pp.3231-3271, 2005.
DOI : 10.1111/j.1742-4658.2005.04741.x

L. Guarente and C. Kenyon, Genetic pathways that regulate ageing in model organisms, Nature, vol.408, issue.6809, pp.255-262, 2000.
DOI : 10.1038/35041700

B. H. Hasegawa, The Physics of Medical X-ray Imaging, 1990.

P. A. Jeggo, 5 DNA Breakage and Repair, Adv. Genet, vol.38, pp.185-218, 1998.
DOI : 10.1016/S0065-2660(08)60144-3

G. Karp, Cell & Molecular Biology -Concepts & Experiments Tr -Second Edition, 1998.

S. Majumdar, A. Sema-issever, A. Burghardt, J. Lotz, F. Arfelli et al., Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure, European Radiology, vol.14, issue.8, pp.1440-1448, 2004.
DOI : 10.1007/s00330-004-2355-8

B. Marples, B. G. Wouters, S. J. Collis, A. J. Chalmers, and C. Joiner, -Phase Cells, Radiation Research, vol.161, issue.3, pp.247-255, 2004.
DOI : 10.1667/RR3130

URL : https://hal.archives-ouvertes.fr/hal-00656345

A. Kuettner, L. D. Margulis, and . Chapman, Diffraction-enhanced X-ray imaging of articular cartilage, Osteoarthritis and cartilage, vol.10, pp.163-171, 2002.

E. Tromba, E. Vallazza, and . Castelli, Experimental evaluation of a simple algorithm to enhance the spatial resolution in scanned radiographic systems, Med Phys, vol.27, issue.11, pp.2609-2625, 2000.

S. Rajdev and F. Sharp, Stress Proteins as Molecular Markers of Neurotoxicity, Toxicologic Pathology, vol.30, issue.1, pp.105-112, 2000.
DOI : 10.1177/019262330002800113

W. Rénier, K. Gamo, A. Joubert, Z. Bencokova, J. Gastaldo et al., Human HSP70-1 is a phosphorylation substrate of ATM that is required for stress signaling and DNA double-strand breaks repair pathways in response to ionizing radiation, 2006.

K. Rothkamm and M. Lobrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses, Proceedings of the National Academy of Sciences, vol.100, issue.9, pp.5057-5062, 2003.
DOI : 10.1073/pnas.0830918100

J. A. Ryan and L. E. Hightower, Stress proteins as molecular biomarkers for environmental toxicology, Stress Inducible Cellular Responses EXS, vol.77, pp.411-424, 1996.
DOI : 10.1007/978-3-0348-9088-5_28

S. C. Short, S. Bourne, C. Martindale, M. Woodcock, and S. P. Jackson, DNA Damage Responses at Low Radiation Doses, Radiation Research, vol.164, issue.3, pp.292-302, 2005.
DOI : 10.1667/RR3421.1

T. Takahashi, H. Mizobuchi, M. Toda, A. Maeda, S. Mizuno et al., Metabolic effects of X-ray irradiation on adult human articular chondrocytes, International Journal of Molecular Medicine, vol.11, issue.5, pp.631-635, 2003.
DOI : 10.3892/ijmm.11.5.631

J. M. Velazquez and S. Lindquist, hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery, Cell, vol.36, issue.3, pp.655-662, 1984.
DOI : 10.1016/0092-8674(84)90345-3

P. Reime, A. Coan, F. Bravin, G. Arvelli, R. Heitner et al., Options and Limitations of Joint Cartilage Imaging: DEI in Comparison to MRI and Sonography, Nucl. Instr. Meth. A, vol.548, pp.47-53, 2005.

A. Wagner, M. Aurich, M. Stoessel, N. Sieber, W. Wetzel et al., Chance and limit of imaging of articular cartilage in vitro in healthy and arthritic joints: DEI (diffraction enhanced imaging) in comparison with MRI, CT, and ultrasound, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, 2005.
DOI : 10.1117/12.589614

A. Wagner, A. Sachse, M. Keller, O. Wagner, M. Aurich et al., Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging, Physics in Medicine and Biology, vol.51, issue.5, pp.1313-1324, 2006.
DOI : 10.1088/0031-9155/51/5/019

W. J. Welch and J. P. Suhan, Cellular and biochemical events in mammalian cells during and after recovery from physiological stress, The Journal of Cell Biology, vol.103, issue.5, pp.2035-2052, 1986.
DOI : 10.1083/jcb.103.5.2035

M. Material, 207 6.2.2 Data analysis and discussion 212 6.3 DEIWAVE: a wave-optical approach code, 214 6.3.2 Experimental data and signal simulation details

C. and V. G. Kohn, Dynamical theory of X-ray diffraction in crystals with defects, 232 REFERENCES A. M. Afanas'ev, pp.421-430, 1971.

A. Authier, Dynamical theory of X -ray diffraction, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00130752

A. Authier and D. Simon, Application de la th??orie dynamique de S. Tagaki au contraste d'un d??faut plan en topographie par rayons X. I. Faute d'empilement, Acta Crystallographica Section A, vol.24, issue.5, pp.517-526, 1968.
DOI : 10.1107/S0567739468001130

M. Born and E. Wolf, Principles of optics: electromagnetic theory of propagation, interference and diffraction of light, 1999.
DOI : 10.1017/CBO9781139644181

A. Bravin, V. Mocella, C. Ferrero, P. Coan, S. Fiedler et al., A wavefront propagation approach to Diffraction Imaging

C. A. Carvalho and Y. Epelboin, Simulation of X-ray traverse topographs and synchrotron Laue topographs: application of the reciprocity theorem, Acta Crystallographica Section A Foundations of Crystallography, vol.49, issue.3, pp.467-473, 1993.
DOI : 10.1107/S0108767392010729

P. Cloetens, Contribution to Phase Contrast Imaging, Reconstruction and Tomography with hard Synchrotron Radiation. Principles, Implementation and Applications, 1999.

P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel et al., Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction, Journal of Synchrotron Radiation, vol.12, issue.2, pp.241-245, 2005.
DOI : 10.1107/S0909049504028444

T. Davis, X-Ray Diffraction Imaging Using Perfect Crystals, Journal of X-Ray Science and Technology, vol.6, issue.4, pp.317-342, 1996.
DOI : 10.1006/jxra.1996.0021

Y. Epelboin, V. Mocella, and A. Soyer, Optical characteristics of synchrotron sources and their influence in the simulation of X-ray topographs, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.357, issue.1761, pp.2731-2739, 1999.
DOI : 10.1098/rsta.1999.0462

URL : https://hal.archives-ouvertes.fr/hal-01215125

A. L. Evans, The evaluation of medical images, A. H. Ltd. Bristol, 1981.

J. P. Guigay, A simple view of the spherical wave in dynamical theory, Acta Crystallographica Section A Foundations of Crystallography, vol.55, issue.3, pp.561-563, 1999.
DOI : 10.1107/S0108767399000173

J. Keyriläinen, M. Fernández, and P. Suortti, Refraction contrast in X-ray imaging, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.488, issue.1-2, pp.419-427, 2002.
DOI : 10.1016/S0168-9002(02)00442-4

V. Mocella, Y. Epelboin, and J. P. Guigay, X-ray dynamical diffraction: the concept of a locally plane wave, Acta Crystallographica Section A Foundations of Crystallography, vol.56, issue.3, pp.308-316, 2000.
DOI : 10.1107/S0108767300002865

Y. I. Nesterets, T. E. Gureyev, K. M. Pavlov, D. M. Paganin, and S. W. Wilkins, Combined analyser-based and propagation-based phase-contrast imaging of weak objects, Optics Communications, vol.259, issue.1, pp.19-31, 2006.
DOI : 10.1016/j.optcom.2005.08.055

Y. Uesugi, M. J. Yagi, R. A. Morgan, and . Lewis, Unification of analyser-based and propagationbased X-ray phase-contrast imaging, Nucl. Instr. Meth. A, vol.548, pp.163-168, 2005.

K. M. Pavlov, T. E. Gureyev, D. Paganin, Y. I. Nesterets, M. J. Morgan et al., Linear systems with slowly varying transfer functions and their application to x-ray phase-contrast imaging, Journal of Physics D: Applied Physics, vol.37, issue.19, 2004.
DOI : 10.1088/0022-3727/37/19/021

S. Takagi, A Dinamical Theory of Diffraction for a Distorted Crystal, Journal of the Physical Society of Japan, vol.26, issue.5, 1969.

T. Uragami, Pendell??sung Fringes of X-Rays in Bragg Case, Journal of the Physical Society of Japan, vol.27, issue.1, pp.147-154, 1969.
DOI : 10.1143/JPSJ.27.147

R. R. Bernhardt, D. Scharnweber, B. Müller, P. Thurner, H. Schliephake et al., Comparison of Microfocus- and Synchrotron X-ray Tomography for the Analysis of Osteointegration around Ti6Al4V Implants, European Cells and Materials, vol.7, pp.42-51, 2004.
DOI : 10.22203/eCM.v007a05

R. A. Brooks and G. D. Chiro, Beam hardening in X-ray reconstructive tomography, Physics in Medicine and Biology, vol.21, issue.3, pp.390-398, 1976.
DOI : 10.1088/0031-9155/21/3/004

P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel et al., Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction, Journal of Synchrotron Radiation, vol.12, issue.2, pp.241-245, 2005.
DOI : 10.1107/S0909049504028444

P. Coan, A. Peterzol, S. Fiedler, C. Ponchut, J. C. Labiche et al., Evaluation of imaging performance of a taper optics CCD `FReLoN' camera designed for medical imaging, Journal of Synchrotron Radiation, vol.13, issue.3, pp.260-270, 2006.
DOI : 10.1107/S0909049506008983

P. M. Joseph and R. D. Spital, The effects of scatter in x-ray computed tomography, Medical Physics, vol.9, issue.4, pp.464-72, 1982.
DOI : 10.1118/1.595111

G. Karp, Cell & Molecular Biology -Concepts & Experiments Tr -Second Edition, 1998.

M. Elo, P. Tenhunen, W. Suortti, and . Thomlinson, Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology, European Journal of Radiology, vol.53, pp.226-237, 2005.

S. Majumdar, A. Sema-issever, A. Burghardt, J. Lotz, F. Arfelli et al., Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure, European Radiology, vol.14, issue.8, pp.1440-1448, 2004.
DOI : 10.1007/s00330-004-2355-8

A. Kuettner, L. D. Margulis, and . Chapman, Diffraction-enhanced X-ray imaging of articular cartilage, Osteoarthritis and cartilage, vol.10, pp.163-171, 2002.

C. Muehleman, L. D. Chapman, K. E. Kuettner, J. Rieff, J. A. Mollenhauer et al., Radiography of rabbit articular cartilage with diffraction-enhanced imaging, The Anatomical Record, vol.450, issue.1, pp.392-397, 2003.
DOI : 10.1002/ar.a.10043

.. Extinction, Width of the Point Spread Function of a crystal, pp.258-259

R. A. Authier, Dynamical theory of X -ray diffraction, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00130752

T. Davis, X-Ray Diffraction Imaging Using Perfect Crystals, Journal of X-Ray Science and Technology, vol.6, issue.4, pp.317-342, 1996.
DOI : 10.1006/jxra.1996.0021

A. Freund, Performance of x???ray optics at the European Synchrotron Radiation Facility, Review of Scientific Instruments, vol.67, issue.9, 1996.
DOI : 10.1063/1.1147397

J. P. Guigay, A simple view of the spherical wave in dynamical theory, Acta Crystallographica Section A Foundations of Crystallography, vol.55, issue.3, pp.561-563, 1999.
DOI : 10.1107/S0108767399000173

R. James, The optical principles of the diffraction of X-rays, 1965.

T. Matsushita and H. Hashizume, X-Ray monochromators. Handbook on Synchrotron Radiation, E, 1983.

M. Sanchez-del-rio, C. Ferrero, and V. Mocella, Computer simulations of bent perfect crystal diffraction profiles, 1997.

W. H. Zachariasen, Theory of X-ray diffraction in crystals List of the publications produced in the framework of this PhD Thesis Phase contrast imaging developments On qualitative and quantitative analysis in analyser based imaging, J. Wiley & Sons Inc Acta Crystallographica. Section A, vol.62, pp.296-308, 1945.

?. P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel et al., Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction, Journal of Synchrotron Radiation, vol.12, issue.2, pp.241-245, 2005.
DOI : 10.1107/S0909049504028444

?. E. Pagot, S. Fiedler, P. Cloetens, A. Bravin, P. Coan et al., Quantitative comparison between two phase contrast techniques: diffraction enhanced imaging and phase propagation imaging, Physics in Medicine and Biology, vol.50, issue.4, pp.709-724, 2005.
DOI : 10.1088/0031-9155/50/4/010

?. S. Fiedler, E. Pagot, P. Cloetens, A. Bravin, J. Baruchel et al., Evaluation of two phase contrast techniques: diffraction-enhanced imaging and propagation, Medical Imaging 2003: Physics of Medical Imaging, 2003.
DOI : 10.1117/12.480245

?. E. Pagot, P. Cloetens, A. Bravin, S. Fiedler, P. Coan et al., A method to extract quantitative information in analyzer-based x-ray phase contrast imaging, Applied Physics Letters, vol.82, issue.20, pp.3421-3423, 2003.
DOI : 10.1063/1.1575508

?. A. Osteoarthritis, A. Wagner, M. Sachse, O. Keller, M. Wagner et al., Quality evaluation of Titanium Implant Ingrowth into Bone by Diffraction Enhanced Imaging (DEI), Physics in Medicine and Biology, vol.51, pp.1313-1324, 2006.

P. Reime, A. Coan, F. Bravin, G. Arfelli, R. Heitner et al., Options and Limitations of Joint Cartilage Imaging: DEI in Comparison to MRI and Sonography, Nuclear Instruments and Methods A, vol.548, pp.47-53, 2005.

?. A. Wagner, M. Aurich, M. Stoessel, N. Sieber, W. D. Wetzel et al., Chance and limit of imaging of articular cartilage in vitro in healthy arthritic joints -DEI (Diffraction Enhanced Imaging) in comparison with MRI, CT and ultrasound Detector characterization Evaluation of image performance of a taper optics CCD " FReLoN " camera designed for medical imaging, SPIE Proceeding Journal of Synchrotron Radiation, vol.574613, pp.542-549, 2005.

?. A. Peterzol, A. Bravin, P. Coan, and H. Elleaume, Performance of the K-edge digital subtraction angiography imaging system at the European synchrotron radiation facility, Radiation Protection Dosimetry, vol.117, issue.1-3, pp.44-49, 2006.
DOI : 10.1093/rpd/nci710

?. A. Bravin, S. Fiedler, P. Coan, J. Labiche, C. Ponchut et al., Comparison between a position sensitive germanium detector and a taper optics CCD ???FRELON??? camera for diffraction enhanced imaging, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.510, issue.1-2, pp.35-40, 2003.
DOI : 10.1016/S0168-9002(03)01675-9

?. A. Peterzol, A. Bravin, P. Coan, and H. Elleaume, Image quality evaluation of the angiography imaging system at the European synchrotron radiation facility, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.510, issue.1-2, pp.45-50, 2003.
DOI : 10.1016/S0168-9002(03)01677-2