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DEVELOPMENT AND APPLICATION OF THE ANALYZER-BASED IMAGING TECHNIQUE WITH HARD SYNCHROTRON RADIATION

Abstract : THE OBJECTIVE OF THIS THESIS IS TWOFOLD: FROM ONE SIDE THE APPLICATION OF THE ANALYSER-BASED X-RAY PHASE CONTRAST IMAGING TO STUDY CARTILAGE, BONE AND BONE IMPLANTS USING THE ID17 AND ID19 ESRF SYNCHROTRON RADIATION SOURCES AND ON THE OTHER TO CONTRIBUTE TO THE DEVELOPMENT OF THE PHASE CONTRAST TECHNIQUES FROM THE THEORETICAL AND EXPERIMENTAL POINT OF VIEW.
SEVERAL HUMAN SAMPLES HAVE BEEN STUDIED IN VITRO USING THE ANALYSER BASED IMAGING (ABI) TECHNIQUE. EXAMINATION INCLUDED PROJECTION AND COMPUTED TOMOGRAPHY IMAGING AND 3D VOLUME RENDERING OF HIP, BIG TOE AND ANKLE ARTICULAR JOINTS. X-RAY ABI IMAGES HAVE BEEN CRITICALLY COMPARED WITH THOSE OBTAINED WITH THE CONVENTIONAL TECHNIQUES, INCLUDING RADIOGRAPHY, COMPUTED TOMOGRAPHY, ULTRASOUND, MAGNETIC RESONANCE AND HISTOLOGY, THE LATTER TAKEN AS GOLD STANDARD. RESULTS SHOW THAT ONLY ABI IMAGING WAS ABLE TO EITHER VISUALIZE OR CORRECTLY ESTIMATE THE EARLY PATHOLOGICAL STATUS OF THE CARTILAGE. THE STATUS OF THE BONE INGROWTH IN SHEEP IMPLANTS HAVE ALSO BEEN EXAMINED IN VITRO: ABI IMAGES PERMITTED TO CORRECTLY DISTINGUISH BETWEEN GOOD AND INCOMPLETE BONE HEALING. PIONEERING IN-VIVO ABI ON GUINEA PIGS WERE ALSO SUCCESSFULLY PERFORMED, CONFIRMING THE POSSIBLE USE OF THE TECHNIQUE TO FOLLOW UP THE PROGRESSION OF JOINT DISEASES, THE BONE/METAL INGROWTH AND THE EFFICACY OF DRUGS TREATMENTS.
AS PART OF THE DEVELOPMENT OF THE PHASE CONTRAST TECHNIQUES, TWO OBJECTIVES HAVE BEEN REACHED. FIRSTLY, IT HAS BEEN EXPERIMENTALLY DEMONSTRATED FOR THE FIRST TIME THAT THE ABI AND THE PROPAGATION BASED IMAGING (PBI) CAN BE COMBINED TO CREATE IMAGES WITH ORIGINAL FEATURES (HYBRID IMAGING, HI). SECONDLY, IT HAS BEEN PROPOSED AND EXPERIMENTALLY TESTED A NEW SIMPLIFIED SET-UP CAPABLE TO PRODUCE IMAGES WITH PROPERTIES SIMILAR TO THOSE OBTAINED WITH THE ABI TECHNIQUE OR HI.
FINALLY, BOTH THE ABI AND THE HI HAVE BEEN THEORETICAL STUDIED WITH AN INNOVATIVE, WAVE-BASED SIMULATION PROGRAM, WHICH WAS ABLE TO CORRECTLY REPRODUCE EXPERIMENTAL RESULTS.
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https://tel.archives-ouvertes.fr/tel-00174514
Contributor : Paola Coan <>
Submitted on : Monday, September 24, 2007 - 3:06:59 PM
Last modification on : Monday, September 24, 2007 - 4:19:07 PM
Long-term archiving on: : Thursday, April 8, 2010 - 8:42:02 PM

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  • HAL Id : tel-00174514, version 1

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Paola Coan. DEVELOPMENT AND APPLICATION OF THE ANALYZER-BASED IMAGING TECHNIQUE WITH HARD SYNCHROTRON RADIATION. Biological Physics [physics.bio-ph]. European Synchrotron Radiation Facility (ESRF), 2006. English. ⟨tel-00174514⟩

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