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Structure, évolution et expression de gènes « chimériques » spécifiques des Primates

Abstract : Processes of genome, and particularly primates genome, evolution are the focus of this thesis. The questions of conservation, or not, of nucleotidic sequences for peptidic precursors in the primate lineage, and of creation, evolution and expression of two primate-specific genes families are examined.

Exon shuffling, retroposition, duplications... are implicated in the creation of novel genes. Studying the creation and first times of a gene requires the description of recent genes, still harbouring their creation features.
Two such genes families retained my attention:
1. The PMCHL genes were created recently trough retroposition and rehandling events, but also indels and mutations accumulation. Structural and phylogenetic analyses favoured a better comprehension of the origin of these primates specific genes. The PMCHL genes are transcribed in a tissues-specific manner, and many alternative splicing are described. Finally, PMCHL mRNA expression has been compared in Macaque and Human brains.
2. The GUSB-derived genes have been identified through Fluorescent In Situ Hybridization on primates chromosomes. A systematic search in the human genome allowed the discovery and description of a big gene family encompassing at least 15 paralogous in human. The structural and phylogenetic analyses we performed led to a more precise description of their creation and evolution. Some members of this genes family acquired a transcriptional capacity.
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Contributor : Nadine Loudig <>
Submitted on : Monday, September 10, 2007 - 9:39:45 AM
Last modification on : Wednesday, October 14, 2020 - 4:23:36 AM
Long-term archiving on: : Friday, April 9, 2010 - 1:43:33 AM


  • HAL Id : tel-00170281, version 1



Fleur Toulemonde-Darre. Structure, évolution et expression de gènes « chimériques » spécifiques des Primates. Biochimie [q-bio.BM]. Université Nice Sophia Antipolis, 2007. Français. ⟨tel-00170281⟩



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