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Theses

Développement de vecteurs lentiviraux regulables pour le transfert de gène dans le système nerveux central.

Abstract : Gene therapy is seen in the future for the treatment of numerous diseases of the nervous system. The transfer of genes could be used to make up for the absence or the dysfunctioning of a deficient gene, to code a therapeutic protein, or to inhibit a gene by means of RNA inhibition. The use of lentiviral vectors to transfer a therapeutic gene is a promising approach for future therapeutic applications. However, for a secure use of these vectors it is necessary to control the express of the therapeutic genes. This allows one to adapt the treatment to the needs of the patient or to stop it in case of severe complications. In this context, my work has led to develop regulatory systems. The integration of efficient systems of regulation within a unique lentiviral vector forms a crucial step for the secure use of these vectors in human therapy.
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Theses
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https://tel.archives-ouvertes.fr/tel-00168863
Contributor : Jacques Mallet <>
Submitted on : Thursday, August 30, 2007 - 3:29:14 PM
Last modification on : Wednesday, December 9, 2020 - 3:12:08 PM
Long-term archiving on: : Friday, April 9, 2010 - 1:21:10 AM

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  • HAL Id : tel-00168863, version 1

Citation

Lahouari Amar. Développement de vecteurs lentiviraux regulables pour le transfert de gène dans le système nerveux central.. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2007. Français. ⟨tel-00168863⟩

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