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Theses

Syntheses in the bibyridine series. Study of the interaction with DNA

Abstract : We have developped the synthesis of heterocycles derived from indolizines and carrying a cationic pyridinium substituent, and studied their interaction with DNA. The key-step of the synthesis of the indolizines is a [3+2] dipolar cycloaddition of ylides formed from quaternary 4,4'-bipyridinium salts with dipolarophiles. The synthesis was done either in classical conditions (solvent, temperature) or by microwave irradiation ("green chemistry"). We have studied the acid-base properties of the bipyridinium salts and their biological activities. The electrical and optical properties along with the photolumiscence of theindolizines are promissing for potential applications as biomedical markers. The interaction of indolizines with DNA was also studied. Finally, we have evaluated the antioxidant properties of indolizines, that have shown an inhibition of peroxidation of vegetal oils in vitro.
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https://tel.archives-ouvertes.fr/tel-00166634
Contributor : Bianca Stegarescu-Furdui <>
Submitted on : Wednesday, August 8, 2007 - 7:53:51 AM
Last modification on : Friday, November 6, 2020 - 3:49:34 AM
Long-term archiving on: : Monday, September 24, 2012 - 11:30:58 AM

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  • HAL Id : tel-00166634, version 1

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Bianca Stegarescu-Furdui. Syntheses in the bibyridine series. Study of the interaction with DNA. Other. Université Joseph-Fourier - Grenoble I, 2006. Romanian. ⟨tel-00166634⟩

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