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STRUCTURES, STABILITÉ ET FONCTIONS DU CYTOSQUELETTE D'ACTINE DANS LES OSTÉOCLASTES MÂTURES

Abstract : Osteoclasts are hematopoietic cells specialized in bone resorption. Actin cytoskeleton organisation depends on substrates: podosomes are observed on glass or plastic slides, whereas an homogenous actin belt, the sealing zone (SZ) is organized on resorption substrates. Study of WIP deficient cells allows us to demontrate existence of 2 actin domains: podosomes cores surrounded by actin cloud. These 2 domains are induced by different receptors, CD44 and Beta3, polymerized by 2 distinct pathways, and are implicated in adhesion and contraction os osteoclast. Podosomes cores and actin cloud reorganized into an unique structure, the SZ, when osteoclast is seeded on apatite or dentin slides. We have also demonstrated that stability of podosomes belt depends on microtubules.
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https://tel.archives-ouvertes.fr/tel-00165656
Contributor : Anne Chabadel <>
Submitted on : Friday, July 27, 2007 - 2:07:39 AM
Last modification on : Sunday, June 7, 2020 - 4:15:54 AM
Long-term archiving on: : Thursday, April 8, 2010 - 9:02:20 PM

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  • HAL Id : tel-00165656, version 1
  • PRODINRA : 251490

Citation

Anne Chabadel. STRUCTURES, STABILITÉ ET FONCTIONS DU CYTOSQUELETTE D'ACTINE DANS LES OSTÉOCLASTES MÂTURES. Biochimie [q-bio.BM]. Ecole normale supérieure de lyon - ENS LYON, 2007. Français. ⟨tel-00165656⟩

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