Abstract : The main objective of this work has been to run a climate simulation of the 21st century that includes not only greenhouse gases and aerosols emitted by human activity but also land-use and land-cover changes. To achieve this goal, the integrated impact model IMAGE2.2 (developped at RIVM, The Netherlands) was used, which simulates the evolution of greenhouse gases concentrations as well as land-cover changes. This model has been coupled to the general circulation model ARPEGE/OPA provided by the CNRM. Before coupling the models, sensitivity experiments with each model have been performed to test thir respective sensitivity to the forcing of the other. Ultimately, a simulation with the two models coupled together has shown that interactions between climate and vegetation are not of primary importance for century scale studies.