A. Chung, A. Fukuda, H. Hikita, T. Seto, T. Okada et al., Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim, EMBO J, issue.24, p.22665364, 2003.

C. M. Allan, A. Garcia, J. Spaliviero, F. P. Zhang, M. Jimenez et al., Complete Sertoli Cell Proliferation Induced by Follicle-Stimulating Hormone (FSH) Independently of Luteinizing Hormone Activity: Evidence from Genetic Models of Isolated FSH Action, Endocrinology, vol.145, issue.4, p.158793, 2004.
DOI : 10.1210/en.2003-1164

J. K. Amory and W. Bremner, Endocrine regulation of testicular function in men: implications for contraceptive development, Molecular and Cellular Endocrinology, vol.182, issue.2, p.1759, 2001.
DOI : 10.1016/S0303-7207(01)00562-7

C. E. Andoniou, N. L. Lill, C. B. Thien, M. L. Lupher, S. Jr et al., The Cbl protooncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation, Mol Cell Biol, vol.20, issue.3, p.85167, 2000.

C. E. Andoniou, C. B. Thien, and W. Y. Langdon, Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene, EMBO J, vol.13, issue.19, p.451523, 1994.

M. D. Anway, A. S. Cupp, M. Uzumcu, and M. K. Skinner, Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility, Science, vol.308, issue.5727, p.14669, 2005.
DOI : 10.1126/science.1108190

J. Bart, H. J. Groen, W. T. Van-der-graaf, H. Hollema, N. H. Hendrikse et al., An oncological view on the blood???testis barrier, The Lancet Oncology, vol.3, issue.6, p.35763, 2002.
DOI : 10.1016/S1470-2045(02)00776-3

M. Bartkiewicz, A. Houghton, and R. Baron, Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl: A ROLE IN c-Cbl's TYROSINE PHOSPHORYLATION AND ITS ASSOCIATION WITH EPIDERMAL GROWTH FACTOR RECEPTOR, Journal of Biological Chemistry, vol.274, issue.43, p.2743088795, 1999.
DOI : 10.1074/jbc.274.43.30887

C. P. Belani, L. A. Doyle, and J. Aisner, Etoposide: current status and future perspectives in the management of malignant neoplasms, Cancer Chemotherapy and Pharmacology, vol.19, issue.Suppl 13
DOI : 10.1007/BF00684875

S. A. Bisson, E. E. Ujack, and S. M. Robbins, Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line, Oncogene, vol.21, issue.23, p.367787, 2002.
DOI : 10.1038/sj.onc.1205510

G. R. Blackledge, Clinical progress with a new antiandrogen, Casodex (bicalutamide), Eur Urol, vol.29, issue.2, p.96104, 1996.

T. J. Blake, K. G. Heath, and W. Y. Langdon, The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation, EMBO J, vol.12, issue.5, p.201726, 1993.

T. J. Blake, M. Shapiro, H. C. Morse, and W. Y. Langdon, The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif, Oncogene, vol.6, issue.4, p.6537, 1991.

K. L. Borden and P. S. Freemont, The RING finger domain: a recent example of a sequence???structure family, Current Opinion in Structural Biology, vol.6, issue.3, pp.395-401, 1996.
DOI : 10.1016/S0959-440X(96)80060-1

V. A. Boussiotis, G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler, Maintenance of human T cell anergy, p.2

F. Boussouar and M. Benahmed, Lactate and energy metabolism in male germ cells, Trends in Endocrinology & Metabolism, vol.15, issue.7, p.34550, 2004.
DOI : 10.1016/j.tem.2004.07.003

A. Bozec, F. Chuzel, S. Chater, C. Paulin, R. Bars et al., The mitochondrial-dependent pathway is chronically aected in testicular germ cell death in adult rats exposed in utero to anti-androgens, J Endocrinol, vol.183, issue.1, p.7990, 2004.

J. R. Brody, E. S. Calhoun, E. Gallmeier, T. D. Creavalle, and S. E. Kern, Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media, Biotechniques, vol.37, issue.600, pp.598-602, 2004.

D. A. Burden and N. Oshero, Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1400, issue.1-3, p.13954, 1998.
DOI : 10.1016/S0167-4781(98)00132-8

X. R. Bustelo, P. Crespo, M. Lopez-barahona, J. S. Gutkind, and M. Barbacid, Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation, Oncogene, vol.15, issue.21, p.15251120, 1997.
DOI : 10.1038/sj.onc.1201430

R. J. Carmody and T. G. Cotter, Signalling apoptosis: a radical approach, Redox Report, vol.159, issue.274, p.7790, 2001.
DOI : 10.1074/jbc.273.51.34272

Y. Chao, E. N. Shiozaki, S. M. Srinivasula, D. J. Rigotti, R. Fairman et al., Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation, PLoS Biology, vol.905, issue.6, p.183, 2005.
DOI : 10.1371/journal.pbio.0030183.t002

I. K. Hu, J. S. Jang, E. Gutkind, H. Shevach, and . Gu, Cbl-b regulates BIBLIOGRAPHY the CD28 dependence of T-cell activation, Nature, issue.6766, p.40321620, 2000.

R. Chiusaroli, A. Sanjay, K. Henriksen, M. T. Engsig, W. C. Horne et al., Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones, Developmental Biology, vol.261, issue.2, pp.537-584, 2003.
DOI : 10.1016/S0012-1606(03)00299-9

C. Combet, C. Blanchet, C. Geourjon, and G. Deleage, NPS@: Network Protein Sequence Analysis, Trends in Biochemical Sciences, vol.25, issue.3, p.14750, 2000.
DOI : 10.1016/S0968-0004(99)01540-6
URL : https://hal.archives-ouvertes.fr/hal-00313012

L. Corsois, B. Quatannens, P. Dumont, M. Aumercier, M. P. Defresne et al., Association of a new c-Cbl related protein with the very first stages of apoptosis induction, Cancer Detection and Prevention, vol.26, issue.2, pp.93-104, 2002.
DOI : 10.1016/S0361-090X(02)00006-5

N. N. Danial and S. J. Korsmeyer, Cell Death, Cell, vol.116, issue.2, p.20519, 2004.
DOI : 10.1016/S0092-8674(04)00046-7

G. C. Davies, S. A. Ettenberg, A. O. Coats, M. Mussante, S. Ravichandran et al., Cbl-b interacts with ubiquitinated proteins; dierential functions of the UBA domains of c-Cbl and Cbl-b, Oncogene, issue.42, p.23710415, 2004.

D. G. De-rooij, Proliferation and dierentiation of spermatogonial stem cells, Reproduction, vol.121, issue.3, p.34754, 2001.

G. Denis, S. Mandard, C. Humblet, M. Verlaet, J. Boniver et al., Nuclear localization of a new c-cbl related protein, CARP 90, during in vivo thymic apoptosis in mice, Cell Death and Differentiation, vol.6, issue.7, p.68997, 1999.
DOI : 10.1038/sj.cdd.4400542

Q. L. Deveraux and J. C. Reed, IAP family proteinssuppressors of apoptosis, Genes Dev, vol.13, issue.3, p.23952, 1999.

A. Dierich, M. R. Sairam, L. Monaco, G. M. Fimia, A. Gansmuller et al., Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance, Proceedings of the National Academy of Sciences, vol.13, issue.4, p.95136127, 1998.
DOI : 10.1093/humrep/13.4.916

I. Dikic, I. Szymkiewicz, and P. Soubeyran, Cbl signaling networks in the regulation of cell function, Cellular and Molecular Life Sciences (CMLS), vol.60, issue.9, p.180527, 2003.
DOI : 10.1007/s00018-003-3029-4

J. A. Donovan, Y. Ota, W. Y. Langdon, and L. E. Samelson, Regulation of the association of p120cbl with Grb2 in Jurkat T cells, J Biol Chem, issue.42, p.2712636974, 1996.

J. A. Donovan, R. L. Wange, W. Y. Langdon, and L. E. Samelson, The protein product of the c-cbl protooncogene is the 120-kDa tyrosinephosphorylated protein in Jurkat cells activated via the T cell antigen receptor, J Biol Chem, issue.37, p.269229214, 1994.

A. K. Dubey, A. J. Zeleznik, and T. M. Plant, In the rhesus monkey (Macaca mulatta), the negative feedback regulation of folliclestimulating hormone secretion by an action of testicular hormone directly at the level of the anterior pituitary gland cannot be accounted for by either testosterone or estradiol, Endocrinology, issue.6, p.121222937, 1987.

G. J. Dulos and W. M. Bagchus, Androgens indirectly accelerate thymocyte apoptosis, International Immunopharmacology, vol.1, issue.2, p.3218, 2001.
DOI : 10.1016/S1567-5769(00)00029-1

M. Dym, Drawing: Seminiferous Tubule, The Male Reproductive System, pp.979-1038, 1977.

D. J. Elliott and S. N. Grellscheid, Alternative RNA splicing regulation in the testis, Reproduction, vol.132, issue.6, p.8119, 2006.
DOI : 10.1530/REP-06-0147

C. Elly, S. Witte, Z. Zhang, O. Rosnet, S. Lipkowitz et al., Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation, Oncogene, vol.18, issue.5, p.18114756, 1999.
DOI : 10.1038/sj.onc.1202411

S. A. Ettenberg, A. Magnico, M. Cuello, M. M. Nau, Y. R. Rubinstein et al., Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex, Journal of Biological Chemistry, vol.276, issue.29, p.2762767784, 2001.
DOI : 10.1074/jbc.M102641200

S. A. Ettenberg, Y. R. Rubinstein, P. Banerjee, M. M. Nau, M. M. Keane et al., cbl-b Inhibits EGF-Receptor-Induced Apoptosis by Enhancing Ubiquitination and Degradation of Activated Receptors, Molecular Cell Biology Research Communications, vol.2, issue.2, p.1118, 1999.
DOI : 10.1006/mcbr.1999.0157

A. Florin, M. Maire, A. Bozec, A. Hellani, S. Chater et al., Androgens and Postmeiotic Germ Cells Regulate Claudin-11 Expression in Rat Sertoli Cells, Endocrinology, vol.146, issue.3, p.146153240, 2005.
DOI : 10.1210/en.2004-0834

R. A. Fox, M. Sigman, and K. Boekelheide, Transmembrane versus soluble stem cell factor expression in human testis, J Androl, vol.21, issue.4, pp.579-85, 2000.

L. R. Franca, G. G. Parreira, R. J. Gates, and L. D. Russell, Hormonal regulation of spermatogenesis in the hypophysectomized rat: quantitation of germ-cell population and eect of elimination of residual testosterone after long-term hypophysectomy, J Androl, vol.19, issue.3412, p.33540, 1998.

P. S. Freemont, I. M. Hanson, and J. Trowsdale, A novel cysteine-rich sequence motif, Cell, vol.64, issue.3, p.4834, 1991.
DOI : 10.1016/0092-8674(91)90229-r

P. Fuentes-prior and G. S. Salvesen, The protein structures that shape caspase activity, specicity, activation and inhibition

F. Scott and . Gilbert, Sex determination (21), volume Developmental Biology, 1994.

T. Goldkorn, N. Balaban, M. Shannon, V. Chea, K. Matsukuma et al., H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells, J Cell Sci, p.111320920, 1998.

L. Gorelik and R. A. , Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells, Nat Med, vol.7, issue.10, p.111822, 2001.

L. Goth, [The hydrogen peroxide paradox], Orv Hetil, vol.147, issue.19, p.88793, 2006.

E. K. Griths, O. Sanchez, P. Mill, C. Krawczyk, C. V. Hojilla et al., Cbl-3-decient mice exhibit normal epithelial development, Journal Article, pp.770818-0270, 2003.

M. D. Griswold, Interactions Between Germ Cells and Sertoli Cells in the Testis, Biology of Reproduction, vol.52, issue.2, p.2116, 1995.
DOI : 10.1095/biolreprod52.2.211

L. M. Grovdal, E. Stang, A. Sorkin, and I. H. Madshus, Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation, Experimental Cell Research, vol.300, issue.2, pp.388-95, 2004.
DOI : 10.1016/j.yexcr.2004.07.003

A. Grover, C. E. Smith, D. G. Gregory, M. R. Cyr, L. Sairam et al., Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility, Molecular Reproduction and Development, vol.12, issue.2, pp.135-179, 2005.
DOI : 10.1002/mrd.20303

K. Haglund, N. Shimokawa, I. Szymkiewicz, and I. Dikic, Cbldirected monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors, Proc Natl Acad Sci U S A, issue.19, p.99121916, 2002.

K. L. Herbst and S. Bhasin, Testosterone action on skeletal muscle, Current Opinion in Clinical Nutrition and Metabolic Care, vol.7, issue.3
DOI : 10.1097/00075197-200405000-00006

C. Heyting and A. J. Dietrich, Meiotic chromosome preparation and protein labeling, Methods Cell Biol, vol.35, p.177202, 1991.
DOI : 10.1016/s0091-679x(08)60573-7

G. R. Hime, M. P. Dhungat, A. Ng, and D. D. Bowtell, D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites, Oncogene, vol.14, issue.22, p.14270919, 1997.
DOI : 10.1038/sj.onc.1201223

K. Hofmann and P. Bucher, The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway, Trends in Biochemical Sciences, vol.21, issue.5
DOI : 10.1016/S0968-0004(96)30015-7

R. W. Holdcraft and R. E. Braun, Hormonal regulation of spermatogenesis, International Journal of Andrology, vol.63, issue.6, p.33542, 2004.
DOI : 10.1210/en.136.12.5311

C. J. Howlett and S. M. Robbins, Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation, Oncogene, vol.21, issue.11, p.170716, 2002.
DOI : 10.1038/sj.onc.1205228

F. Huang and A. Sorkin, Growth factor receptor binding protein 2- mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sucient to support receptor endocytosis, Mol Biol Cell, vol.16, issue.3, p.126881, 2005.

J. Dadoune and A. Demoulin, La reproduction chez les mammifères et l'homme, Chapitre, vol.13, 2001.

M. S. Jeon, A. Ateld, K. Venuprasad, C. Krawczyk, R. Sarao et al., Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction, Immunity, vol.21, issue.2, p.16777, 2004.
DOI : 10.1016/j.immuni.2004.07.013

I. Ji, C. Lee, Y. Song, P. M. Conn, and T. H. Ji, Cis-and transactivation of hormone receptors: the LH receptor, Mol Endocrinol, vol.16, issue.6, p.1299308, 2002.

X. Jiang, F. Huang, A. Marusyk, and A. Sorkin, Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits, Molecular Biology of the Cell, vol.14, issue.3, p.85870, 2003.
DOI : 10.1091/mbc.E02-08-0532

C. A. Joazeiro and A. M. Weissman, RING nger proteins: mediators of ubiquitin ligase activity, Cell, vol.102, issue.5, p.54952, 2000.

L. Johnson, C. S. Petty, and W. B. Neaves, Inuence of age on sperm production and testicular weights in men, J Reprod Fertil, vol.70, issue.1, p.2118, 1984.

D. S. Johnston, L. D. Russell, P. J. Friel, and M. D. Griswold, Murine Germ Cells Do Not Require Functional Androgen Receptors to Complete Spermatogenesis Following Spermatogonial Stem Cell Transplantation, Endocrinology, vol.142, issue.6, p.14224058, 2001.
DOI : 10.1210/endo.142.6.8317

G. D. Jongeward, T. R. Clandinin, and P. W. Sternberg, sli-1, a negative regulator of let-23-mediated signaling in C. elegans, Genetics, vol.139, issue.4, p.155366, 1995.

N. H. Jutte, J. A. Grootegoed, F. F. Rommerts, and H. J. Van-der-molen, Exogenous lactate is essential for metabolic activities in isolated rat spermatocytes and spermatids, Reproduction, vol.62, issue.2, p.399405, 1981.
DOI : 10.1530/jrf.0.0620399

M. Kangasniemi, A. Kaipia, J. Toppari, P. Mali, I. Huhtaniemi et al., Cellular regulation of basal and FSH-stimulated cyclic AMP production in irradiated rat testes, The Anatomical Record, vol.165, issue.1, p.326, 1990.
DOI : 10.1002/ar.1092270105

N. O. Karpinich, M. Tafani, R. J. Rothman, M. A. Russo, and J. L. Farber, The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c, J Biol Chem, issue.19, p.2771654752, 2002.

C. K. Kassenbrock and S. M. Anderson, Regulation of Ubiquitin Protein Ligase Activity in c-Cbl by Phosphorylation-induced Conformational Change and Constitutive Activation by Tyrosine to Glutamate Point Mutations, Journal of Biological Chemistry, vol.279, issue.27, p.2792801727, 2004.
DOI : 10.1074/jbc.M404114200

M. M. Keane, S. A. Ettenberg, M. M. Nau, P. Banerjee, M. Cuello et al., cbl-3: a new mammalian cbl family protein, Journal Article, pp.18336575-0950, 1999.
DOI : 10.1038/sj.onc.1202753

M. M. Keane, O. M. Rivero-lezcano, J. A. Mitchell, K. C. Robbins, and S. Lipkowitz, Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene, Oncogene, issue.12, p.10236777, 1995.

S. K. Kendall, T. L. Saunders, L. Jin, R. V. Lloyd, L. M. Glode et al., Targeted Ablation of Pituitary Gonadotropes in Transgenic Mice, Molecular Endocrinology, vol.5, issue.12, pp.2025-2061, 1991.
DOI : 10.1210/mend-5-12-2025

J. B. Kerr, S. Maddocks, and R. M. Sharpe, Testosterone and FSH have independent, synergistic and stage-dependent eects upon spermatogenesis in the rat testis, Cell Tissue Res, vol.268, issue.1, p.17989, 1992.

J. F. Kerr, A. H. Wyllie, and A. R. Currie, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, vol.26, issue.4, p.23957, 1972.

J. Kerr, The Cytology Of The Human Testis, volume The Testis, 1989.

R. Kim, M. Emi, and K. Tanabe, Role of mitochondria as the gardens of cell death, Cancer Chemotherapy and Pharmacology, vol.290, issue.5, p.54553, 2006.
DOI : 10.1007/s00280-005-0111-7

M. F. Kleijnen, R. M. Alarcon, and P. M. Howley, The ubiquitinassociated domain of hPLIC-2 interacts with the proteasome, Mol Biol Cell, vol.14, issue.9, p.386875, 2003.

C. Krawczyk, K. Bachmaier, T. Sasaki, R. G. Jones, S. B. Snapper et al., Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells, Immunity, vol.13, issue.4, p.46373, 2000.
DOI : 10.1016/S1074-7613(00)00046-7

H. Krishnamurthy, P. S. Babu, C. R. Morales, and M. R. Sairam, Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse, Biol Reprod, vol.65, issue.2, p.52231, 2001.

H. Krishnamurthy, N. Danilovich, C. R. Morales, and M. R. Sairam, Qualitative and quantitative decline in spermatogenesis of the folliclestimulating hormone receptor knockout (FORKO) mouse, Biol Reprod, vol.62, issue.5, p.114659, 2000.

H. Krishnamurthy, R. Kats, N. Danilovich, D. Javeshghani, and M. R. Sairam, Intercellular communication between Sertoli cells and Leydig cells in the absence of follicle-stimulating hormone-receptor signaling

T. R. Kumar, Y. Wang, N. Lu, and M. M. Matzuk, Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility, Nature Genetics, vol.61, issue.2, p.2014, 1997.
DOI : 10.1038/ng0297-201

3. Morse, v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas, Proc Natl Acad Sci U S A, vol.86, issue.4, p.116872, 1989.

W. Y. Langdon, K. G. Heath, and T. J. Blake, The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation, Curr Top Microbiol Immunol, vol.182, p.46774, 1992.
DOI : 10.1007/978-3-642-77633-5_59

L. J. Pelliniemi, K. Fröjdman, and J. Paranko, Molecular Biology Of The Male Reproductive System, 1993.

A. Lawen, Apoptosis?an introduction, BioEssays, vol.12, issue.102, p.88896, 2003.
DOI : 10.1002/bies.10329

B. , L. Magueresse-battistoni, G. Pernod, L. Kolodie, A. M. Morera et al., Tumor necrosis factor-alpha regulates plasminogen activator inhibitor-1 in rat testicular peritubular cells, Endocrinology, issue.3, p.1381097105, 1997.

Y. J. Lee, J. C. Chen, A. A. Amoscato, J. Bennouna, D. R. Spitz et al., Protective role of Bcl2 in metabolic oxidative stress-induced cell death, J Cell Sci, pp.114677-84, 2001.

Z. M. Lei, S. Mishra, P. Ponnuru, X. Li, Z. W. Yang et al., Testicular phenotype in luteinizing hormone receptor knockout animals and the eect of testosterone replacement therapy, Biol Reprod, issue.5, p.71160513, 2004.

G. Levkowitz, H. Waterman, S. A. Ettenberg, M. Katz, A. Y. Tsygankov et al., Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1, Molecular Cell, vol.4, issue.6
DOI : 10.1016/S1097-2765(00)80231-2

G. Levkowitz, H. Waterman, E. Zamir, Z. Kam, S. Oved et al., c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor, Genes & Development, vol.12, issue.23, p.12366374, 1998.
DOI : 10.1101/gad.12.23.3663

N. L. Lill, P. Douillard, R. A. Awwad, S. Ota, M. L. Lupher et al., The evolutionarily conserved N-terminal region of Cbl is sucient to enhance down-regulation of the epidermal growth factor receptor, J Biol Chem, vol.275, issue.1, p.36777, 2000.

J. Liu, S. M. Deyoung, J. B. Hwang, E. E. Leary, and A. R. Saltiel, The Roles of Cbl-b and c-Cbl in Insulin-stimulated Glucose Transport, Journal of Biological Chemistry, vol.278, issue.38, p.2783675462, 2003.
DOI : 10.1074/jbc.M300664200

Y. C. Liu and H. Gu, Cbl and Cbl-b in T-cell regulation, Trends in Immunology, vol.23, issue.3, p.1403, 2002.
DOI : 10.1016/S1471-4906(01)02157-3

I. Livne, A. J. Silverman, and M. J. Gibson, Reversal of reproductive deciency in the hpg male mouse by neonatal androgenization, Biol Reprod, vol.47, issue.4, p.5617, 1992.

E. J. Lowenstein, R. J. Daly, A. G. Batzer, W. Li, B. Margolis et al., The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling, Cell, vol.70, issue.3, p.7043142, 1992.
DOI : 10.1016/0092-8674(92)90167-B

M. L. Lupher, N. Jr, M. J. Rao, H. Eck, and . Band, The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction, Immunology Today, vol.20, issue.8, p.2037582, 1999.
DOI : 10.1016/S0167-5699(99)01484-X

W. Matthews, J. Driscoll, K. Tanaka, A. Ichihara, and A. L. Goldberg, Involvement of the proteasome in various degradative processes in mammalian cells., Proceedings of the National Academy of Sciences, vol.86, issue.8, p.862597601, 1989.
DOI : 10.1073/pnas.86.8.2597

C. Mckinnell and R. M. Sharpe, Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage BIBLIOGRAPHY VI-VIII seminiferous tubules from adult rats, J Androl, vol.16, issue.6, p.499509, 1995.

S. J. Meachem, R. I. Mclachlan, D. M. De-kretser, D. M. Robertson, and N. G. Wreford, Neonatal exposure of rats to recombinant follicle stimulating hormone increases adult Sertoli and spermatogenic cell numbers, Biology of Reproduction, vol.54, issue.1, p.3644, 1996.
DOI : 10.1095/biolreprod54.1.36

H. Meisner, A. Daga, J. Buxton, B. Fernandez, A. Chawla et al., Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development., Molecular and Cellular Biology, vol.17, issue.4
DOI : 10.1128/MCB.17.4.2217

F. Melander, T. Andersson, and K. Dib, Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils, Biochem Biophys Res Commun, vol.317, issue.4, p.10005, 2004.

. Braun, Androgens regulate the permeability of the blood-testis barrier

W. Meng, S. Sawasdikosol, S. J. Burako, and M. J. Eck, Structure of the amino-terminal domain of cbl complexed to its binding site on zap- 70 kinase, Journal Article, pp.3988490-3988518, 1999.

O. Michael, M. L. Thorner, J. Vance, R. Edward, E. Laws et al., Chapter 9: The Anterior Pituitary, W.B. Saunders, 1998.

M. Temkin, Image : Rat Testis Seminiferous Tubule Cross- Section 400x, Atlas Of Developmental Stages

G. J. James and . Cooney, c-Cbl-decient mice have reduced adiposity, BIBLIOGRAPHY higher energy expenditure, and improved peripheral insulin action, J Clin Invest, vol.114, issue.9, p.132633, 2004.

D. D. Mruk and C. Y. Cheng, Sertoli-Sertoli and Sertoli-germ cell interactions and their signicance in germ cell movement in the seminiferous epithelium during spermatogenesis, Endocr Rev, vol.25, issue.5, p.747806, 2004.

M. A. Murphy, R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello et al., Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-decient mice, Mol Cell Biol, issue.8, p.18487282, 1998.

K. Nagaosa, A. Kishimoto, R. Kizu, A. Nakagawa, A. Shiratsuchi et al., Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice, Reproduction, vol.133, issue.1, p.217, 2007.
DOI : 10.1530/REP-06-0236

M. Naramura, I. K. Jang, H. Kole, F. Huang, D. Haines et al., c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligandinduced TCR down-modulation, Nat Immunol, vol.3, issue.12, p.11929, 2002.

M. M. Nau and S. Lipkowitz, Comparative genomic organization of the cbl genes, Gene, vol.308, p.10313, 2003.
DOI : 10.1016/S0378-1119(03)00471-2

P. Negri-cesi, A. Colciago, F. Celotti, and M. Motta, Sexual dierentiation of the brain: role of testosterone and its active metabolites, J Endocrinol Invest, vol.27, issue.6, p.1207, 2004.

S. C. Newton, O. W. Blaschuk, and C. F. Millette, N-cadherin mediates sertoli cell-spermatogenic cell adhesion, Developmental Dynamics, vol.159, issue.1, p.113, 1993.
DOI : 10.1002/aja.1001970102

K. Nishimori and M. M. Matzuk, Transgenic mice in the analysis of reproductive development and function, Reviews of Reproduction, vol.1, issue.3, p.20312, 1996.
DOI : 10.1530/ror.0.0010203

J. C. Obenauer, L. C. Cantley, and M. B. Yae, Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs, Nucleic Acids Research, vol.31, issue.13, pp.31363541-1362, 2003.
DOI : 10.1093/nar/gkg584

H. Odai, K. Sasaki, Y. Hanazono, H. Ueno, T. Tanaka et al., c-Cbl is inducibly tyrosinephosphorylated by epidermal growth factor stimulation in broblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed broblasts, Jpn J Cancer Res, issue.12, p.86111926, 1995.

N. J. Olsen, S. M. Viselli, J. Fan, and W. J. Kovacs, Androgens Accelerate Thymocyte Apoptosis, Endocrinology, vol.139, issue.2, p.74852, 1998.
DOI : 10.1210/en.139.2.748

A. Omezzine, S. Chater, C. Mauduit, A. Florin, E. Tabone et al., Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to utamide, Endocrinology, vol.144, issue.2, p.64861, 2003.

F. Cruz-munoz, S. J. Oceguera-yanez, Y. Burako, and . Rosenstein, Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells, J Biol Chem, vol.276, issue.1, p.72937, 2001.

F. Pognan, M. T. Masson, F. Lagelle, and C. Charuel, Establishment of a rat Sertoli cell line that displays the morphological and some of the functional characteristics of the native cell, Cell Biol Toxicol, vol.13, issue.6, p.45363, 1997.

S. A. Pratt, N. F. Scully, and B. D. Shur, Cell surface beta 1,4 galactosyltransferase on primary spermatocytes facilitates their initial adhesion to Sertoli cells in vitro, Biol Reprod, vol.49, issue.3, p.47082, 1993.

J. Druker, H. Wu, and . Band, The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation

W. Y. Copeland, H. C. Langdon, and . Morse, Identication of two BIBLIOGRAPHY murine loci homologous to the v-cbl oncogene, J Virol, vol.3, issue.639, p.367882, 1989.

V. Ribon and A. R. Saltiel, Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes, Biochemical Journal, vol.324, issue.3, p.83945, 1997.
DOI : 10.1042/bj3240839

E. Ritzén, V. Hansson, and F. French, The Sertoli Cell, volume The Testis, 1989.

M. Hypogonadism, Medline Plus Medical Encyclopedia http, 2006.

H. Robertson, G. R. Hime, H. Lada, and D. D. Bowtell, A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo, Oncogene, vol.19, issue.29, p.193299308, 2000.
DOI : 10.1038/sj.onc.1203624

G. S. Roeder and J. M. Bailis, The pachytene checkpoint, Trends in Genetics, vol.16, issue.9, p.395403, 2000.
DOI : 10.1016/S0168-9525(00)02080-1

L. D. Russel, A. P. Ettlin, S. Hikim, and E. D. Clegg, Histological and Histopathological Evaluation of the Testis, International Journal of Andrology, vol.16, issue.1, 1990.
DOI : 10.1111/j.1365-2605.1993.tb01156.x

M. R. Sairam and H. Krishnamurthy, The Role of Follicle-Stimulating Hormone in Spermatogenesis, Archives of Medical Research, vol.32, issue.6
DOI : 10.1016/S0188-4409(01)00328-9

J. W. Saunders and J. , Death in Embryonic Systems, Science, vol.154, issue.3749, pp.604-616, 1966.
DOI : 10.1126/science.154.3749.604

S. Sawasdikosol, J. C. Pratt, W. Meng, M. J. Eck, and S. J. Burako, Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1471, issue.1, pp.1471-1472, 2000.
DOI : 10.1016/S0304-419X(00)00013-5

M. H. Schmidt and I. Dikic, The Cbl interactome and its functions, Nature Reviews Molecular Cell Biology, vol.4, issue.12, 2005.
DOI : 10.1038/nrm1762

F. Scott and . Gilbert, Developmental Biology, 1994.

B. Setchell and L. Pilsworth, The Functions of the Testes of Vertebrate and Invertebrate Animals, volume The Testis, 1989.

R. M. Sharpe, S. Maddocks, and J. B. Kerr, Cell-cell interactions in the control of spermatogenesis as studied using leydig cell destruction and testosterone replacement, American Journal of Anatomy, vol.123, issue.1, p.320, 1990.
DOI : 10.1002/aja.1001880103

S. C. Shih, K. E. Sloper-mould, and L. Hicke, Monoubiquitin carries a novel internalization signal that is appended to activated receptors, The EMBO Journal, vol.96, issue.2
DOI : 10.1093/emboj/19.2.187

J. Singh and D. J. Handelsman, Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropindecient (hpg) mice, J Endocrinol, vol.151, issue.1, p.3748, 1996.

J. Singh, C. O. Neill, and D. J. Handelsman, Induction of spermatogenesis by androgens in gonadotropin-decient (hpg) mice, Endocrinology, vol.136, issue.12, p.531121, 1995.

S. Sinha, J. Jancarik, V. Roginskaya, K. Rothermund, L. M. Boxer et al., Suppression of apoptosis and granulocyte colonystimulating factor-induced dierentiation by an oncogenic form of Cbl

G. H. Son, E. Park, H. Jung, J. Han, K. H. Lee et al., GnRH pre-mRNA splicing: solving the mystery of a nature???s knockout, hpg mouse, Biochemical and Biophysical Research Communications, vol.326, issue.2, p.2617, 2005.
DOI : 10.1016/j.bbrc.2004.10.207

J. A. Spaliviero, M. Jimenez, C. M. Allan, and D. J. Handelsman, Luteinizing hormone receptor-mediated eects on initiation of spermatogenesis in gonadotropin-decient (hpg) mice are replicated by testosterone, Biol Reprod, vol.70, issue.1, p.328, 2004.

G. Swaminathan and A. Y. Tsygankov, The Cbl family proteins: Ring leaders in regulation of cell signaling, Journal of Cellular Physiology, vol.20, issue.1, 2006.
DOI : 10.1002/jcp.20694

I. Szymkiewicz, K. Kowanetz, P. Soubeyran, A. Dinarina, S. Lipkowitz et al., CIN85 Participates in Cbl-b-mediated Down-regulation of Receptor Tyrosine Kinases, Journal of Biological Chemistry, vol.277, issue.42, p.2773966672, 2002.
DOI : 10.1074/jbc.M205535200

S. Tanaka, M. Amling, L. Ne, A. Peyman, E. Uhlmann et al., c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption, Nature, vol.383, issue.6600, p.38352831, 1996.
DOI : 10.1038/383528a0

C. B. Thien and W. Y. Langdon, Cbl: many adaptations to regulate protein tyrosine kinases, Nat Rev Mol Cell Biol, vol.2, issue.4, p.294307, 2001.

C. B. Thien and W. Y. Langdon, Negative regulation of PTK signalling by Cbl proteins, Growth Factors, vol.23, issue.2, p.1617, 2005.

G. J. Todaro and H. Green, QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES, The Journal of Cell Biology, vol.17, issue.2, p.299313, 1963.
DOI : 10.1083/jcb.17.2.299

Y. Tsujimoto, J. Cossman, E. Jae, and C. M. Croce, Involvement of the bcl-2 gene in human follicular lymphoma, Science, vol.228, issue.4706, pp.2281440-2281443, 1985.
DOI : 10.1126/science.3874430

D. L. Vaux, Apoptosis Timeline, Cell Death and Differentiation, vol.9, issue.4, p.34954, 2002.
DOI : 10.1038/sj.cdd.4400990

D. L. Vaux, I. L. Weissman, and S. K. Kim, Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2, BIBLIOGRAPHY [165] Victoria College Biology Department. Image: Seminiferous tubules with interstitial space 100x, Course Supplement, 1992.
DOI : 10.1126/science.1470921

H. Wartenberg, Dierentation and Development of the Testes, volume The Testis, 1989.

H. Waterman, M. Katz, C. Rubin, K. Shtiegman, S. Lavi et al., A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling, The EMBO Journal, vol.11, issue.3
DOI : 10.1093/emboj/21.3.303

H. Waterman, G. Levkowitz, I. Alroy, and Y. Yarden, The RING nger of c-Cbl mediates desensitization of the epidermal growth factor receptor, J Biol Chem, issue.32, p.274221514, 1999.

J. D. Wilson, Role of dihydrotestosterone in androgen action, Prostate Suppl, vol.6, p.8892, 1996.

E. A. Wohlfert, L. Gorelik, R. Mittler, R. A. Flavell, and R. B. Clark, Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-?? Sensitivity In Vitro and In Vivo, The Journal of Immunology, vol.176, issue.3, p.131620, 2006.
DOI : 10.4049/jimmunol.176.3.1316

I. D. Wu and . Morris, Apoptosis in the rat spermatogenic epithelium following androgen withdrawal: changes in apoptosis-related genes

M. Yokouchi, T. Kondo, A. Houghton, M. Bartkiewicz, W. C. Horne et al., Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING nger and UbcH7, J Biol Chem, issue.44, p.2743170712, 1999.

M. Yokouchi, T. Kondo, A. Sanjay, A. Houghton, A. Yoshimura et al., Src-catalyzed phosphorylation BIBLIOGRAPHY of c-Cbl leads to the interdependent ubiquitination of both proteins, J Biol Chem, issue.37, p.2763518593, 2001.

C. H. Yoon, C. Chang, N. A. Hopper, G. M. Lesa, and P. W. Sternberg, Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval dierentiation, Mol Biol Cell, issue.11, p.11401931, 2000.

C. H. Yoon, J. Lee, G. D. Jongeward, and P. W. Sternberg, Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl, Science, vol.76, issue.5, p.26911025, 1995.
DOI : 10.1016/0092-8674(94)90367-0

X. Yu, D. Acehan, J. F. Menetret, C. R. Booth, S. J. Ludtke et al., A Structure of the Human Apoptosome at 12.8 ?? Resolution Provides Insights into This Cell Death Platform, Structure, vol.13, issue.11, p.13172535, 2005.
DOI : 10.1016/j.str.2005.09.006

S. Zeng, Z. Xu, S. Lipkowitz, and J. B. Longley, Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl), Blood, vol.105, issue.1, p.22632, 2005.
DOI : 10.1182/blood-2004-05-1768

F. P. Zhang, T. Pakarainen, F. Zhu, M. Poutanen, and I. Huhtaniemi, Molecular Characterization of Postnatal Development of Testicular Steroidogenesis in Luteinizing Hormone Receptor Knockout Mice, Endocrinology, vol.145, issue.3, p.145145363, 2004.
DOI : 10.1210/en.2003-1049

J. Zhang, T. Bardos, D. Li, I. Gal, C. Vermes et al., Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination, The Journal of Immunology, vol.169, issue.5, p.223640, 2002.
DOI : 10.4049/jimmunol.169.5.2236

Z. Zhang, C. Elly, L. Qiu, A. Altman, and Y. C. Liu, A direct interaction between the adaptor protein Cbl-b and the kinase Zap-70 induces a positive signal in T cells, Current Biology, vol.9, issue.4, p.2036, 1999.
DOI : 10.1016/S0960-9822(99)80090-6

N. Zheng, P. Wang, P. D. Jerey, and N. P. Pavletich, Structure of a c-Cbl???UbcH7 Complex, Journal Article, pp.5339-0092, 2000.
DOI : 10.1016/S0092-8674(00)00057-X

Q. Zhou, R. Nie, G. S. Prins, P. T. Saunders, B. S. Katzenellenbogen et al., Localization of androgen and estrogen receptors in adult male mouse reproductive tract, J Androl, vol.23, issue.6, p.87081, 2002.

H. Zou, W. J. Henzel, X. Liu, A. Lutschg, and X. Wang, Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c???Dependent Activation of Caspase-3, Cell, vol.90, issue.3, p.9040513, 1997.
DOI : 10.1016/S0092-8674(00)80501-2