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Attention divisée et mémoire de travail après un Traumatisme Crânien Sévère. Approche en Neuropsychologie et en Imagerie fonctionnelle (IRMf, MEG)

Abstract : We studied patients with severe Traumatic Brain Injury (sTBI). The main aim was to characterize the cognitive mechanisms involved in Divided Attention (DA) impairments after sTBI, and particularly, to analyse the relationship between cognitive slowness and Working Memory (WM) load. Patients and controls were given a n-back task of three different load levels, that was performed as a single and a dual task. Patients demonstrated, as expected, a difficulty in dual-task processing and an increased susceptibility to high working memory load, but dual-task performance and working memory load did not interact as expected. These results are in accordance with recent findings suggesting that dual-task performance and other working memory functions represent dissociable although interrelated abilities.
The second aim was to explore the anatomical and neurophysiological correlates of WM impairments after sTBI using fMRI and MEG. Two main results were found :
1. All stages of information processing were slowed down in sTBI patients. This slowing down increases with the late cognitive processing involving prefrontal cortex, suggesting a more general executive dysfunction, not specifically bound to the WM
2. The bilateral parieto-frontal network found in control subjects was disrupted in sTBI patients, with : defect of lateralization of the prefrontal cortex, hypoactivation of the whole network, and supplementary cortical activations (fronto-polar region).
fMRI and MEG data indicate that sTBI patients were significantly slower than control subjects, and that the slowing down is a global phenomenon, but prefrontal regions seem to be more affected by this slowness of information processing. In addition, cortical activations of these regions were decreased in sTBI patients.
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https://tel.archives-ouvertes.fr/tel-00161833
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Submitted on : Wednesday, July 11, 2007 - 4:52:52 PM
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  • HAL Id : tel-00161833, version 1

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Sybille Asloun. Attention divisée et mémoire de travail après un Traumatisme Crânien Sévère. Approche en Neuropsychologie et en Imagerie fonctionnelle (IRMf, MEG). Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2006. Français. ⟨tel-00161833⟩

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