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Altérations génétiques des cholinestérases chez des souris : conséquences morphologiques et fonctionnelles à la jonction neuromusculaire

Abstract : At the vertebrate neuromuscular junction, two enzymes can hydrolize acetylcholine (ACh): acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Advances in mouse genomics offers new approaches to assess the role of specific cholinesterases involved in neuromuscular transmission. We have several lines of mice which present a deficit in the hydrolysis of ACh at the neuromuscular junctions (NMJ). The functional and morphological consequences at the NMJ were analyzed by electrophysiological and confocal microscopy approaches.
In spite of AChE deficient, mice develop tetanic contractions in physiological frequencies but cannot maintain them at high frequencies. Moreover, the pre and post-synaptic remodelling is probably due to the adaptation of ACh receptors nicotinic (AChR) and of the motor endplate in the absence of enzymatic activity of AChE.
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https://tel.archives-ouvertes.fr/tel-00160337
Contributor : Emmanuelle Girard <>
Submitted on : Thursday, July 5, 2007 - 3:58:11 PM
Last modification on : Monday, October 19, 2020 - 11:12:45 AM

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Emmanuelle Girard. Altérations génétiques des cholinestérases chez des souris : conséquences morphologiques et fonctionnelles à la jonction neuromusculaire. Neurosciences [q-bio.NC]. Museum national d'histoire naturelle - MNHN PARIS, 2006. Français. ⟨tel-00160337⟩

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