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EFFETS PHYSIOLOGIQUES ET PATHOGENIQUES DE L'APORECEPTEUR DE L'HORMONE THYROÏDIENNE ALPHA 1 AU COURS DU DEVELOPPEMENT DE LA SOURIS

Abstract : Thyroid hormone (T3) has pleiotropic functions during development. Congenital hypothyroidism results in severe mental retardation. Using transgenic reporter mice, we showed that T3 action is highly heterogeneous in pre and post-natal brain. The regulation of gene expression by T3 involves binding of the hormone to TR nuclear receptors acting as T3-dependant transcription factors. We identified new T3 direct target genes in postnatal cerebellum, but the T3 signaling cascade is still unknown, because of complexe cell cell interactions. To suppress T3 response in a specific cell type and at a specific time, we created new transgenic mice expressing a mutated TR?1 in a conditional manner. Constitutive mutants have a hypothyroid like phenotype. This confirms the importance of unliganded TR?1 receptor in hypothyroidism pathogenesis. The conditional system will permit to dissect in vivo T3 action.
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00159988
Contributor : Laure Quignodon <>
Submitted on : Thursday, July 5, 2007 - 1:00:48 PM
Last modification on : Sunday, June 7, 2020 - 4:15:50 AM
Long-term archiving on: : Monday, September 24, 2012 - 10:55:09 AM

Identifiers

  • HAL Id : tel-00159988, version 1
  • PRODINRA : 251602

Citation

Laure Quignodon. EFFETS PHYSIOLOGIQUES ET PATHOGENIQUES DE L'APORECEPTEUR DE L'HORMONE THYROÏDIENNE ALPHA 1 AU COURS DU DEVELOPPEMENT DE LA SOURIS. Sciences du Vivant [q-bio]. Ecole normale supérieure de lyon - ENS LYON, 2007. Français. ⟨tel-00159988⟩

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