Skip to Main content Skip to Navigation
Theses

Contrôle homéostatique de l'activité corticale: Etude de la balance Excitation / Inhibition des neurones pyramidaux de couche 5 du cortex visuel.

Abstract : The process of homeostatic plasticity consists in the regulation of the strength of excitatory and inhibitory neuronal inputs in order to prevent a deregulation of neuonal activity. To characterize the mechanisms underlying this process, the Excitation/Inhibition balance of cortical layer 5 pyramidal neurons was estimated. It is composed by 20 % of excitation and 80 % of inhibition. Using stimulation protocols inducing long term changes of the strength of neuronal inputs, the processes of homeostatic potentiation and homeostatic depression were observed. Their induction, which requires the activation of NMDA receptors and a NO signal, is controlled by inhibitory GABAergic and glycinergic systems. The recurrence between excitatory and inhibitory circuits appears as the key element of the regulation of neuronal activity.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00159415
Contributor : Nicolas Le Roux <>
Submitted on : Tuesday, July 3, 2007 - 11:09:23 AM
Last modification on : Thursday, January 11, 2018 - 6:19:38 AM
Long-term archiving on: : Monday, September 24, 2012 - 10:50:43 AM

Identifiers

  • HAL Id : tel-00159415, version 1

Collections

Citation

Nicolas Le Roux. Contrôle homéostatique de l'activité corticale: Etude de la balance Excitation / Inhibition des neurones pyramidaux de couche 5 du cortex visuel.. Neurosciences [q-bio.NC]. Université Paris Sud - Paris XI, 2007. Français. ⟨tel-00159415⟩

Share

Metrics

Record views

767

Files downloads

2870