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Etude de la rigidité de courbure de monocouches de Langmuir en présence d'un peptide antimicrobien

Abstract : Antimicrobial peptides are a part of the natural immune response of many living organisms. These peptides allow a rapid response to infection by diverse bacterial species, without destroying the organism's cells. However, the molecular mechanism involved is still unclear, in particular the action on the membranes bending rigidity. Bending rigidity of Langmuir monolayers (mimicking simplified cell membranes) in presence or not of an antimicrobial peptide are investigated in this work.
The bending rigidities were estimated and measured with four methods: Langmuir Technique, Grazing Incidence Diffraction, Grazing Incidence Diffuse Scattering in sample plane for air/liquid interface and Grazing Incidence Diffuse Scattering in incident beam plane on liquid/liquid interface.
Although each method gives, according to the range it probes, different values for the bending rigidity for a given monolayer, they confirm that in case of monolayers mimicking bacterial cell membranes, presence of the antimicrobial peptide decreases the bending rigidity. In the other hand, in case of monolayers mimicking mammalian cell membranes, due to no interactions between peptide and phospholipids, the bending rigidity doesn't change.
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https://tel.archives-ouvertes.fr/tel-00157944
Contributor : Eric Saint-Martin <>
Submitted on : Wednesday, June 27, 2007 - 1:50:47 PM
Last modification on : Wednesday, June 27, 2007 - 7:27:46 PM
Long-term archiving on: : Thursday, April 8, 2010 - 9:50:49 PM

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  • HAL Id : tel-00157944, version 1

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Eric Saint-Martin. Etude de la rigidité de courbure de monocouches de Langmuir en présence d'un peptide antimicrobien. Analyse de données, Statistiques et Probabilités [physics.data-an]. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00157944⟩

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