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Theses

Etude de 2 gènes cibles de la protéine P53 :
siah (seven in absentia human homologue) et
tsap6 (tumor suppressor activated pathway 6)

Abstract : We studied 2 genes involved in tumor reversion and regulated by P53 : siah-1 and tsap6.
We have identified, in the promoter of the siah-1b gene, a sequence which binds P53 in vivo and in vitro. Furthermore, we showed that this sequence is a functional P53 response element that can under induction of P53 lead to activation of this promoter.
This P53 binding site presents a non-classical structure compared to the consensus described for P53 binding. This could lead to new prospects in the analysis of P53-regulated mechanisms.
We have characterized the tissular and cellular expression of the murine TSAP6. Since TSAP6 function is poorly understood, we started to depict it in animal models bearing a tsap6 gene mutated or deleted.
The mutation Gln-395-Lys in the TSAP6 protein triggers microcytosis and pulmonary emphysema in mouse. The characterization of the mechanisms promoting these phenotypes is in progress and will help us to better understand TSAP6 function.
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https://tel.archives-ouvertes.fr/tel-00157749
Contributor : Séverine Beaucourt (ep. Barth) <>
Submitted on : Wednesday, June 27, 2007 - 7:50:55 AM
Last modification on : Wednesday, June 27, 2007 - 7:44:09 PM
Long-term archiving on: : Thursday, April 8, 2010 - 9:45:01 PM

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  • HAL Id : tel-00157749, version 1

Citation

Séverine Beaucourt. Etude de 2 gènes cibles de la protéine P53 :
siah (seven in absentia human homologue) et
tsap6 (tumor suppressor activated pathway 6). Biologie cellulaire. Université Paris Sud - Paris XI, 2005. Français. ⟨tel-00157749⟩

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