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Modélisation d'un simple brin d'ADN : Configuration en "épingle à cheveux"

Abstract : DNA beacons are made of short single strands of DNA with terminal regions consisting of complementary base sequences. As a result, the two end-regions can self-assemble in a short DNA double helix, called the stem, while the remaining central part of the strand makes a loop. In this closed configuration, the single strand has the shape of a hairpin. Such hairpin conformations are important in determining the secondary structure of long single strands of DNA or RNA.
In this thesis, we have developed two different models in order to study the thermodynamics and the kinetics of such systems. The first one is a planar square lattice model inspired by the lattice models which have been used to study protein folding. The second one includes the physical ingredients of the lattice model but without the constraint of the lattice. It combines polymer theory and the Peyrard-Bishop and Dauxois (PBD) model of DNA melting. With this approach we can compare our results quantitatively with the experimental ones.
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Contributor : Jalal Errami <>
Submitted on : Friday, June 22, 2007 - 3:41:45 PM
Last modification on : Wednesday, November 20, 2019 - 2:55:09 AM
Long-term archiving on: : Thursday, April 8, 2010 - 9:15:19 PM


  • HAL Id : tel-00156784, version 1


Jalal Errami. Modélisation d'un simple brin d'ADN : Configuration en "épingle à cheveux". Data Analysis, Statistics and Probability []. Ecole normale supérieure de lyon - ENS LYON, 2007. English. ⟨tel-00156784⟩



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