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Synthèse de 5-azaindolocarbazoles.
Evaluation de leur activité antitumorale

Abstract : The cancer is a public health problem. The chemotherapy research is in progress, to develop
new and more specific molecules, decreasing the side effects and resistance to drugs. The
indolocarbazoles, antitumor natural molecules, represent a tool of choice for this therapy.
The realised modifications on the squeleton, which are the replacement of an indole moiety
by a 5-azaindole, have allowed to synthesise 5-azaindolocarbazoles.
A detailed study of the 5-azaindole reactivity have been necessary. Based on the various
fonctionnalisations developed on the positions 2 or 3, the synthesis of more complex
compounds was realised. These approches have allowed the construction of the targeted 5-
azaindolocarbazoles. The biological activities, as antitumor drugs, are reported in the
document and criticised.
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Contributor : Laurent Robin <>
Submitted on : Wednesday, May 23, 2007 - 1:51:30 PM
Last modification on : Thursday, March 5, 2020 - 6:49:18 PM
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  • HAL Id : tel-00148832, version 1


Myriam Lefoix. Synthèse de 5-azaindolocarbazoles.
Evaluation de leur activité antitumorale. Autre. Université d'Orléans, 2005. Français. ⟨tel-00148832⟩



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