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IMPLICATIONS DE LA PROTEINE ARL2 DANS LE PHENOTYPE TUMORAL ET LES MECANISMES DE CHIMIORESISTANCE DANS LE CANCER DU SEIN

Abstract : The native form of tubulins heterodimers, essential for their polymerization into microtubules, is obtained after several chaperone proteins action. Arl2 (ADP Ribosylation Factor-like Protein 2) is involved in the regulation of some of these tubulin chaperone proteins. In breast cancer cells models, we have showed that Arl2 expression level perturbations induce (1) important modifications of microtubules dynamic and of mitosis ; (2) chemoresistance to different antitumoral agents by a PP2A-dependant mechanism and associated with p53 transcription factor and (3) alterations of tumoral development. These results have permitted to establish, for the first time, a correlation between regulations of functional tubulin production and microtubular and cellular phenotype of human cancer cells. This work opens new perspectives of identification of new factors implicated in chemoresistance and tumoral development in breast cancer cells.
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https://tel.archives-ouvertes.fr/tel-00147954
Contributor : Anne Beghin <>
Submitted on : Monday, May 21, 2007 - 2:22:03 PM
Last modification on : Wednesday, November 20, 2019 - 3:02:38 AM
Long-term archiving on: : Thursday, April 8, 2010 - 5:14:40 PM

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  • HAL Id : tel-00147954, version 1

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Anne Beghin. IMPLICATIONS DE LA PROTEINE ARL2 DANS LE PHENOTYPE TUMORAL ET LES MECANISMES DE CHIMIORESISTANCE DANS LE CANCER DU SEIN. Biologie cellulaire. Université Claude Bernard - Lyon I, 2007. Français. ⟨tel-00147954⟩

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