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Modélisation par éléments finis des phénomènes électromagnétiques en hyperthermie et optimisation des applicateurs.

Abstract : Hyperthermia is a therapy used in the treatment of cancerous tumors. Hyperthermia increases the temperature of cancerous cells to therapeutic levels between 42 and 45 OC. This elevation of temperature is obtained by submitting locally the patient to a radiofrequency field for deep-seated tumors or to a microwave field for superficial tumors. In the aim to develop a treatment planning software, a 3D numerical model based on edge elements has been elaborated. This model allows calculating the Specific Absorption Rate (SAR) distribution in the patient during hyperthermia treatment. The Results obtained with the finite element model have been compared to experimental measurements performed on a phantom presenting equivalent electromagnetic characteristics than muscle tissues. This comparison realized at a frequency of 27.12 MHz shows a good agreement between both numerical and experimental results. An optimization procedure based on genetic algorithms of the SAR in the patient has been associated to the finite element model. The treatment planning software allows obtaining a better distribution of the SAR in the tumor. Two hyperthermia devices operating at 27.12 MHz and 1 10 MHz and the geometry of the patient stemming from computerized tomography scans have been modelized. The SAR distribution in the patient with these two hyperthermia devices has been optimized with the treatment planning software.
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Submitted on : Thursday, May 3, 2007 - 4:22:30 PM
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  • HAL Id : tel-00144536, version 1


Nicolas Siauve. Modélisation par éléments finis des phénomènes électromagnétiques en hyperthermie et optimisation des applicateurs.. Autre. Ecole Centrale de Lyon, 2002. Français. ⟨tel-00144536⟩



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