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Synthèse et évaluation biologique de dérivés polyquinoléine chélateurs d'ions métalliques en relation avec la maladie d'Alzheimer

Abstract : In Alzheimer's disease, ZnII, CuII and FeIII metal ions interact with the _-amyloid peptide (Ab) to precipitate Ab and generate the toxic H2O2 species. A therapeutic strategy consists in chelating these metal ions with heterocyclic ligands covalently linked to improve their affinity for metal ions. The Cyclo-bi-Phen reduces the amyloid plaques load in transgenic mice mimicking Alzheimer's disease. A second series was designed on the clioquinol model, a quinoline derivative active in vitro and in vivo. More than 20 polyquinoline ligands were synthesized. They display a high affinity for CuII and ZnII. They also inhibit Ab precipitation and H2O2 production due to metal ions in vitro.
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https://tel.archives-ouvertes.fr/tel-00142741
Contributor : Philippe Eyraud <>
Submitted on : Friday, April 20, 2007 - 5:27:58 PM
Last modification on : Friday, January 10, 2020 - 9:08:12 PM
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  • HAL Id : tel-00142741, version 1

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Céline Deraeve. Synthèse et évaluation biologique de dérivés polyquinoléine chélateurs d'ions métalliques en relation avec la maladie d'Alzheimer. Autre. Université Paul Sabatier - Toulouse III, 2006. Français. ⟨tel-00142741⟩

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