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Recherche de gènes et de molécules freinant la dégénérescence musculaire chez deux modèles animaux de la myopathie de Duchenne, Cænorhabditis elegans et la souris mdx.

Abstract : Duchenne muscular dystrophy is a muscular degenerative disease caused by the absence of dystrophin. Dystrophin function and the causes of muscle degeneration in its absence are still not known.
I combined studies in the Caenorhabditis elegans and murine animal models of this disease to elucidate the mechanisms of muscle degeneration.
We demonstrated that the calcium-dependant potassium channel, SLO-1, and the syntrophin homologue, STN-1, are functionally linked to the C. elegans homologue of dystrophin, DYS-1. We ran a genome-wide screen in search of suppressor genes of muscular degeneration. We showed that the protein degradation pathways and several kinases are involved in muscular degeneration in C. elegans. In parallel, I participated to the search of molecules reducing muscle degeneration in C. elegans, and then in mdx mice. We confirmed the beneficial effect of the activation of the serotonergic pathway on the muscular degeneration of mdx mice.
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https://tel.archives-ouvertes.fr/tel-00140848
Contributor : Carre-Pierrat Maïté <>
Submitted on : Tuesday, April 10, 2007 - 2:31:59 PM
Last modification on : Thursday, November 21, 2019 - 2:36:18 AM
Long-term archiving on: : Friday, November 25, 2016 - 4:20:24 PM

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  • HAL Id : tel-00140848, version 1

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Maïté Carre-Pierrat. Recherche de gènes et de molécules freinant la dégénérescence musculaire chez deux modèles animaux de la myopathie de Duchenne, Cænorhabditis elegans et la souris mdx.. Biochimie [q-bio.BM]. Université Claude Bernard - Lyon I, 2006. Français. ⟨tel-00140848⟩

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