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Theses

CONTRIBUTION DES RÉCEPTEURS À DOMAINE DE MORT ET DES RÉCEPTEURS DE LA FAMILLE TOLL À L'HÉMATOPOÏÈSE HUMAINE

Abstract : FADD is an adaptor protein that was originally isolated as a transducer of apoptotic signals for death domain-containing receptors (DR). Analysis of FADD-/- RAG1-/- complementation mice revealed that FADD also plays a critical role in both B and T cell early development possibly through positive regulation of lymphocyte proliferation. Our results reveal that the invalidation of FADD's functions in HSCs dramatically impair hematopoietic development and B cell development. These data suggest that FADD is implicated in HSC expansion and in B cell commitment.
Other receptors like Toll-Like Receptors (TLR) which constitute a subgroup of the Pathogen Recognition Receptors (PRR) family which are non-polymorphic receptors devoted to pathogen recognition, have been shown to recruit FADD. This led us to study the functions of TLR in human hematopoiesis. Here we show that HSCs and progenitors express functional TLRs (TLR1, 2, 4, 6). HSCs stimulation by TLR agonists is susceptible to skew hematopoietic development toward myeloid differentiation at the expense of B cell development. This process could contribute to reinforce innate immunity in the course of microbial infections.
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https://tel.archives-ouvertes.fr/tel-00140434
Contributor : Karelle de Luca <>
Submitted on : Friday, April 6, 2007 - 11:36:46 AM
Last modification on : Friday, October 23, 2020 - 4:37:13 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 1:05:13 AM

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  • HAL Id : tel-00140434, version 1

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Karelle de Luca. CONTRIBUTION DES RÉCEPTEURS À DOMAINE DE MORT ET DES RÉCEPTEURS DE LA FAMILLE TOLL À L'HÉMATOPOÏÈSE HUMAINE. Immunologie. Université Claude Bernard - Lyon I, 2006. Français. ⟨tel-00140434⟩

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